Adaptive damage analysis method for ultimate bearing capacity of steel truss structures with box section.

Traditional damage analysis of steel truss structures requires detailed finite element meshing, and there is a coupling between stress-strain and damage solving, resulting in complex damage analysis and massive computations. In this paper, the element bearing ratio (EBR) reflecting the bearing state of components was defined, and the concept of the element damage factor was introduced based on the principle of deformation energy conservation. A homogeneous generalized yield function (HGYF) for box-section components was constructed to establish adaptive damage factors and the criterion under multi-force combinations.

Glymphatic dysfunction in moyamoya disease: the influence of arterial stenosis and ventricular enlargement.

The glymphatic system is a vascular-dependent network, involving cerebrospinal fluid circulation, that facilitates waste clearance from the brain. Although glymphatic dysfunction has been implicated in various neurologic diseases, its influencing factors are still not fully understood. We aimed to evaluate glymphatic clearance in moyamoya disease (MMD) and explore its associations with arterial stenosis and ventricular size.

Proline betaine facilitates angiogenesis in bronchopulmonary dysplasia.

Background: Bronchopulmonary dysplasia (BPD) is prevalent and severe diseases in preterm infants, characterized by abnormal lung development. This study aims to investigate the therapeutic potential of proline betaine, a natural alkaloid recognized for its vasculo-protective and anti-inflammatory properties, in BPD model.

Methods: Network pharmacology was utilized to predict the targets of proline betaine and BPD-related genes (BPD-RGs).

Source apportionment of polychlorinated dibenzo-p-dioxin/furans and polychlorinated biphenyls in soil from the Gyirong Valley in the Himalayas.

The Tibetan Plateau is an important area for persistent organic pollutants (POPs) research because of high-altitude condensation and global distillation. However, the sources of the POPs in remote regions have not been quantified, which is critical for global control of POPs. The Gyirong Valley in the Himalayas bordering Nepal serves as an important pathway for cross-border transport of POPs to the Tibetan Plateau.

Simultaneous liver transplant and sleeve gastrectomy provides durable weight loss, improves metabolic syndrome and reduces allograft steatosis.

Background And Aims: The prevalence of obesity and metabolic syndrome (MetS) is rising among liver transplant (LT) candidates, many of whom have Metabolic-Associated Steatotic Liver Disease (MASLD). Following LT, untreated obesity often causes recurrent MASLD. We treated patients with obesity with LT and concurrent sleeve gastrectomy (LTSG), aiming to determine long-term impact on obesity, MetS and recurrent MASLD after transplantation.

Discovery of a novel quinoline RIP1 inhibitor and its treatment of acute liver injury in mice.

Necroptosis is closely associated with the development of inflammatory diseases, including acute liver injury. However, the precise role of necroptosis-related signature proteins in acute liver injury remains incompletely understood. Previously, our group investigated Compound o1, a RIP1 inhibitor, but its antinecroptosis activity and RIP1 binding affinity were suboptimal.

Vitiligo associated with type 2 immune inhibitors: FAERS analysis and literature review.

With the widespread use of type 2 immune response inhibitors (IRIs), there is growing concern about their association with the occurrence of vitiligo. This study aimed to comprehensively search for cases of vitiligo associated with type 2 IRIs in the US Food and Drug Administration Adverse Event Reporting System (FAERS). We retrieved the clinical characteristics of cases from January 2004 to September 2024 from the FAERS database.

Full-endoscopic posterior lumbar interbody fusion for the treatment of lumbar degenerative diseases: a technical note with 2-year follow-up.

Introduction: The spinal endoscopic technique has been extensively documented in decompression procedures for treating lumbar degenerative diseases. However, there is limited literature on the spinal endoscopic in lumbar fusion techniques. This study evaluates the outcomes and safety of full-endoscopic posterior lumbar interbody fusion (Endo-PLIF) for the treatment of lumbar degenerative diseases.

The association between lower prognostic nutritional index and higher short- & long-term mortality in older adults (≥ 70 years) undergoing coronary artery bypass grafting: a retrospective study.

Background: The incidence of cardiovascular diseases among old individuals is on the rise with the growing trend of population aging. Coronary artery bypass grafting (CABG) is an important treatment modality for coronary heart diseases and is increasingly employed in older adults. However, concerns arise due to the poor prognosis following surgery in this population.

Exploration of non-coding RNAs related to intramuscular fat deposition Xinjiang Brown cattle and Angus × Wagyu cattle.

Non-coding RNAs (ncRNAs) serve as crucial regulatory elements in the process of adipogenesis in animals; however, the specific roles and interrelationships of ncRNAs in bovine fat deposition remain poorly understood. This study aims to investigate the differentially expressed ncRNAs in the longissimus dorsi muscle of Xinjiang Brown cattle (XB) and Angus Wagyu cattle (AW), to elucidate the regulatory mechanisms underlying lipidogenesis that may involve ncRNAs. Four Xinjiang Brown cattle and four Angus Wagyu cattle were selected, ensuring they are subjected to identical feeding conditions, in order to evaluate the intermuscular fat (IMF) of longissimus dorsi muscles.

Spin excitations in nanographene-based antiferromagnetic spin-1/2 Heisenberg chains.

Antiferromagnetic Heisenberg chains exhibit two distinct types of excitation spectrum: gapped for integer-spin chains and gapless for half-integer-spin chains. However, in finite-length half-integer-spin chains, quantization induces a gap, requiring precise control over sufficiently long chains to study its evolution. Here we create length-controlled spin-1/2 Heisenberg chains by covalently linking Olympicenes-Olympic-ring-shaped magnetic nanographenes.

Association between C-reactive protein and hemoglobin in US rheumatoid arthritis patients based on NHANES data analysis.

The poor prognosis of rheumatoid arthritis (RA) and its potential for complications highlight the importance of understanding factors that are associated with incidence and mortality rates. The inclusion criteria of this study were RA-related data from 1999 to 2018 in the National Health and Nutrition Examination Survey (NHANES) dataset. Based on certain screening criteria, a total of 610 subjects were recruited.

Validation of a Deep Learning Model for Diabetic Retinopathy on Patients with Young-Onset Diabetes.

Introduction: While many deep learning systems (DLSs) for diabetic retinopathy (DR) have been developed and validated on cohorts with an average age of 50s or older, fewer studies have examined younger individuals. This study aimed to understand DLS performance for younger individuals, who tend to display anatomic differences, such as prominent retinal sheen. This sheen can be mistaken for exudates or cotton wool spots, and potentially confound DLSs.

Efficacy of complex decongestive therapy in managing limb swelling, pain, and enhancing functional recovery after arthroscopic reconstruction of anterior cruciate ligament.

Objective: To evaluate the efficacy of Complex Decongestive Therapy (CDT) in managing limb swelling, alleviating pain, and promoting functional recovery in patients following anterior cruciate ligament reconstruction (ACLR).

Method: This was a randomized controlled trial (RCT) involving 160 patients who underwent ACLR at a tertiary hospital in Shenzhen between August 2021 and April 2023. The study compared the outcomes of conventional nursing care with complex decongestive therapy (CDT).

Royal Jelly Acid Alleviates Diet-Induced Hyperlipidemia through Regulation of Oxidative Stress and Tryptophan Metabolism.

Royal jelly acid is a unique unsaturated fatty acid isolated from royal jelly. Recently, royal jelly acid was proposed to have potential therapeutic effects on hyperlipidemia. However, its effect on hyperlipidemia and the underlying molecular mechanism remains unclear.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Uncovering the Fluctuation of Peroxynitrite during Early Embryonic Development Using an Integrative Nanobeacon.

Embryonic development is the beginning of life, and various kinds of bioactive molecules are implicated in this crucial process. Especially in its early stage, some important biochemical reactions regulating physiological balance may be resuscitated. Thus, revealing the dynamic changes of bioactive molecules during early embryonic development is crucial to the elucidation of biological phenomena.

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.

Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like receptor family in humans play a central role in NK cell immunity through recognition of major histocompatibility complex class I (MHC-I) and related molecules. Functionally, these receptor families are involved in the licensing and rejection of MHC-I-deficient cells through missing-self.

Influence of microstructure on metal-ceramic bonding in SLM-manufactured titanium alloy crowns and bridges.

Objectives: This study focuses on the effect of microstructural surface characteristics on metal-ceramic bond strength for SLM-fabricated titanium alloy. This research seeks to improve metal-ceramic adhesion in SLM-produced parts.

Methods: Inspired by the hydrophilic structure of Calathea zebrina, bioinspired microstructures were designed on titanium alloy surfaces.

Microenvironment-Responsive Biomimetic Bioprosthetic Valve with Antithrombosis and Immunoregulation Performance.

The prevalence of heart valve disease (HVD) has escalated worldwide, because of population aging. Currently, artificial heart valve replacement is considered the most effective treatment for HVD. The complexity and risk of heart valve replacement have been markedly reduced with the development of minimally invasive interventional techniques, which has resulted in the more widespread implantation of bioprosthetic heart valves (BHVs); however, they still present with defects including thrombosis, poor cytocompatibility, immune responses, and calcification, which reduces their service life.

Morphology Effect of FeWO Boosting Efficiency of Photocatalytic Uranium Extraction under Visible Light and Mechanism Investigation.

Wolframite (FeWO) is a type of polyoxometalate known for its high chemical stability and electronic properties, which makes it an excellent photocatalyst. While FeWO has been widely utilized in the domain of organic catalysis, there are currently no documented reports regarding its use in the degradation of U(VI). In this study, the effect of changing the microscopic morphology of the FeWO catalyst to enhance its photocatalytic activity was explored.

Cardiac-Specific Gene Editing via an AAV9-Tnnt2-SaCas9-miR122TS Vector.

The adeno-associated virus serotype 9 (AAV9)-delivered gene expression driven by the cardiac troponin T (Tnnt2) promoter is broadly considered to be cardiac-specific. However, in cases where low AAV expression is sufficient to trigger a profound biological effect in CRISPR/Cas9 gene editing, the ectopic AAV9-Tnnt2 expression and gene editing in the liver becomes non-negligible. MicroRNA122 is a microRNA that is specifically expressed in the liver.

Pyrolysis kinetics, mechanism and thermodynamics of peanut shell based on Gaussian function deconvolution.

As a typical biomass resource, peanut shell has the potential to produce energy and value-added products, as it is generated abundantly worldwide. Pyrolysis is increasingly utilized for the disposal of biomass wastes through thermal conversion into chemical raw materials. Assessing the pyrolysis kinetics, reaction mechanism, thermodynamic parameters for individual components of peanut shells is crucial for its valorization.

Remote Ischemic Preconditioning Attenuates Mitochondrial Dysfunction and Ferroptosis of Tubular Epithelial Cells by Inhibiting NOX4-ROS Signaling in Acute Kidney Injury.

Acute kidney injury (AKI) is a worldwide clinical burden associated with high morbidity and mortality. Remote ischemic preconditioning (rIPC), a brief nonlethal ischemia and reperfusion (IR) in remote tissues or limbs, has been used in an attempt to protect against AKI, but its underlying signaling pathways has not been elucidated. In the present study, rIPC protected kidney function and pathological injury and mitigated NADPH oxidase 4 (NOX4) upregulation in different AKI models (cisplatin, LPS and IRI).

Sequencing of high-frequency mutated genes in breast cancer (BRCA) and associated-functions analysis.

Objective: Mutations or aberrant expression of genes in an organism tend not to be completely random and this cumulative effect predisposes to the development of malignant tumours. This study aims to reveal the possible aberrant expression of high frequency mutated genes, and then to investigate their role in development, prognosis, signalling pathway function and drug resistance in breast cancer.

Methods: The mutated genes in breast cancer (BRCA) clinical samples were identified and detected by high-throughput sequencing.