[Application of denaturing high perfomance liquid chromatography in detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis].

Objective: to explore the value of denaturing high performance liquid chromatography (DHPLC) in detection of rpoB mutations in rifampin-resistant M. tuberculosis, in order to establish a convenient and rapid approach to screening rpoB gene mutations in M. tuberculosis.

The diagnostic value of urine-based survivin mRNA test using reverse transcription-polymerase chain reaction for bladder cancer: a systematic review.

Background And Objective: Survivin has gradually become an important target in diagnosis, prognosis prediction and treatment of tumor. There are many studies on urine-based survivin mRNA test using reverse transcription-polymerase chain reaction (RT-PCR) as a noninvasive examination for bladder cancer. However, its clinical value remains controversial.

[Systematic review on sodium ferulate for treatment of diabetic nephropathy].

Objective: To systematically review the efficacy and safety of sodium ferulate (SF) for the treatment of diabetic nephropathy.

Methods: By computerized retrieving the Cochrane Library, MEDLINE, EMBASE, CNKI, VIP, CBM (theses, conference and internet materials), as well as data from internet materials regarding randomized controlled clinical trials of sodium ferulate for the treatment of diabetic nephropathy were collected completely. Data were strictly extracted using the simple evaluation method recommended in Cochrane Handbook and Meta-analysis was performed using Revman 5.

Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials.

Background: Helicobacter pylori (H. pylori) infection and iron deficiency anemia are prevalent in disadvantaged populations worldwide. The benefit of H.

Ultrasonic coagulator for thyroidectomy: a systematic review of randomized controlled trials.

Objective: To evaluate the effect of ultrasonic coagulator for thyroidectomy.

Methods: randomized controlled trials were searched in PubMed, EMBASE, Cochrane Library, SCI, Chinese Biomedical Database, China Academic Journals Full-Text Database, Chinese Scientific Journals Database, and China Online Journals. The authors evaluated the quality of included studies by Handbook 5.

Ixabepilone plus capecitabine with capecitabine alone for metastatic breast cancer.

Aim: We conducted a systematic review to estimate efficacy and safety of ixabepilone plus capecitabine compared with capecitabine alone for patients of anthracycline- and/or taxane-resistant metastatic breast cancer.

Materials & Methods: PubMed, Cochrane Library, EMBASE, ClinicalTrials.gov and other databases were searched.

Robot-assisted laparoscope fundoplication for gastroesophageal reflux disease: a systematic review of randomized controlled trials.

Objective: To evaluate the efficacy and safety of robot-assisted fundoplication (RAF) for treating gastroesophageal reflux disease (GERD).

Methods: Randomized controlled trials (RCTs) or quasi-RCTs were searched for in PubMed, EMBASE, the Cochrane Library, SCI, Chinese Biomedical Database, China Academic Journals Full-Text Database, Chinese Scientific Journals Database, China online journals, and related journals. We evaluated the quality of the included studies by using the 5.

Moxifloxacin-based triple therapy versus clarithromycin-based triple therapy for first-line treatment of Helicobacter pylori infection: a meta-analysis of randomized controlled trials.

Background: Moxifloxacin-based triple therapy has been suggested as an alternative first line therapy to clarithromycin-based triple therapy for Helicobacter pylori infection.

Aims: To systematically review the efficacy and tolerance of moxifloxacin-based triple therapy, and to conduct a meta-analysis of studies comparing this regimen with clarithromycin-based triple therapy.

Methods: A search of The Cochrane Library, PUBMED, EMBASE, EBM Review databases, Science Citation Index Expanded, and CMB (Chinese Biomedical Literature Database) was performed.

Tamsulosin versus terazosin for benign prostatic hyperplasia: a systematic review.

The effectiveness and safety of tamsulosin and terazosin for patients with benign prostatic hyperplasia (BPH) was evaluated by literature review. PubMed, Embase, the Cochrane Library, Chinese biomedicine literature database (CBM), reference lists of reports, and reviews were searched for randomized controlled trials (RCTs), or quasi-RCTs of tamsulosin versus terazosin in BPH. Twelve studies involving 2,816 men were included.

Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis.

The objective of this study was to assess the clinical efficacy and safety of concomitant or adjuvant tomozolomide with whole-brain irradiation (WBI) in patients with brain metastases. MEDLINE, EMBASE, Cochrane Library, Chinese Biomedical Literature Database were searched to identify relevant original published trails, and the references of eligible studies were manually screened. Randomized controlled trails reported in any language, comparing concomitant or adjuvant temozolomide (TMZ) and WBI with WBI alone in patients with brain metastases, were eligible for inclusion.

[(125)I versus (103)Pd brachytherapy for low risk prostate cancer: a systematic review].

Background And Objective: Permanent interstitial prostate brachytherapy is the main treatment for early-stage prostate cancer. (125)I and (103)Pd are the most commonly used radionuclides for prostate brachytherapy, which are different in complications and clinical efficacy. This study was to compare the effectiveness and adverse effects of (125)I and (103)Pd for patients with low risk prostate cancer using transperineal prostate seed implantation.

Three-port versus four-port laparoscopic cholecystectomy: meta-analysis of randomized clinical trials.

Background: Since the first laparoscopic cholecystectomy was reported, the four-trocar laparoscope has become the golden standard procedure. Some surgeons, however, thought that the three-port technique may be safe, effective, and economic. Our meta-analysis compared the three-port technique to the four-port technique.

[The influence of intensive insulin therapy on the mortality of critically ill patients in intensive care unit: a meta-analysis].

Objective: To assess the influence of intensive insulin therapy (IIT), as compared with conventional insulin therapy (CIT), on mortality of critically ill patients in the intensive care unit (ICU) by Meta-analysis.

Methods: Computer retrieval was conducted to search for randomly controlled trials (1966-2009) to compare the result of IIT and CIT. The quality of included studies was critically evaluated and data were analyzed by using the Cochrane Collaboration's RevMan 5.

Open mesh techniques for inguinal hernia repair: a meta-analysis of randomized controlled trials.

Objective: The aim of this report is to evaluate the efficacy of the 3 most common open mesh techniques used in practice.

Background: The open mesh technique of choice, inguinal hernia repair, remains controversial. Some randomized controlled trials (RCTs) have been published assessing its effectiveness; however, available data regarding the outcomes were noncoincident.

Octreotide for advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials.

Purpose: To evaluate the effectiveness of octreotide in advanced hepatocellular carcinoma participants on the basis of randomized controlled trials.

Methods: We searched the Cochrane Center Register of Controlled Trials in The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database, China Journal Full-text Database, Chinese Scientific Journals Database up to June 2008 in any language. Randomized controlled trials of octreotide for advanced hepatocellular carcinoma were selected and evaluated by two investigators.

Intravenous pantoprazole as an adjuvant therapy following successful endoscopic treatment for peptic ulcer bleeding.

Background: Several studies have suggested that proton pump inhibitors are efficacious in preventing rebleeding when administered immediately after endoscopic treatments. However, there are limited clinical outcome data on the use of intravenous pantoprazole.

Objective: To evaluate the efficacy of intravenous pantoprazole after successful endoscopic treatment for peptic ulcer bleeding using evidence from randomized controlled trials (RCTs).

Strategies for promoting the development of evidence-based medicine in China.

Background: Some important events have happened in clinical medicine outside China in recent years changing the field.

Event: A working meeting of the EBM network was held to promote the development of EBM in China. The delegates came from 15 EBM centres in universities or hospitals and some strategies and measures were discussed in the meeting.

[Evaluation of efficacy of thymosin alpha1 in the treatment of sepsis: a systematic review].

Objective: To assess the effects of thymosin alpha1 to enhance immunity and on the prognosis of sepsis.

Methods: The database from CNKI (1994-2008.10), CBM (1978-2008.

Omentoplasty in the prevention of anastomotic leakage after colorectal resection: a meta-analysis.

Purpose: Whether omentoplasty after colorectal anastomosis can reduce anastomotic leakage is controversial. Our aim was to do a meta-analysis of randomized controlled trials to compare anastomotic leakage rates between an omentoplasty group and a no omentoplasty group after colorectal anastomosis.

Materials And Methods: We searched the Cochrane Center Register of Controlled Trials, PubMed, EMBASE, and Chinese Biomedical Literature Database up to June 2008 in any language.

Probiotics in patients with severe acute pancreatitis: a meta-analysis.

Background: This study focuses on probiotics in patients with severe acute pancreatitis. It assesses whether enteral feeding with probiotics use reduces infected necrosis and death in severe acute pancreatitis.

Materials And Methods: We searched the Cochrane Library, Medline, Embase, and Chinese Biomedicine Database.

Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials.

The World Health Organization estimates that at least 12 million people are infected with syphilis in the world. Southeast Asia accounts for 5.8 million; Africa accounts for 3.

[Meta analysis of clinical effectiveness of neoadjuvant chemotherapy for gastric cancer].

Background & Objective: Neoadjuvant chemotherapy has gained increasing attention as a treatment for gastric cancer since Wilke first reported its application to the treatment of gastric cancer in 1989. However, its value in treating gastric cancer remains controversial. This research was to assess the efficacy of neoadjuvant chemotherapy on gastric cancer through a Meta analysis of the randomized controlled trials published worldwide in both English and Chinese.

[A Meta-analysis of high-dose epinephrine in children with cardiopulmonary arrest].

Objective: Epinephrine has a place in the treatment of pediatric cardiopulmonary arrest but has been controversy concerning its optimal dose. This meta-analysis aimed to seek for evidences of the effectiveness of different doses of epinephrine in children with cardiac arrest and to evaluate the effectiveness of high-dose versus standard-dose epinephrine in children with cardiac arrest.

Method: Published papers on randomized controlled trials (RCTs) and prospective clinical controlled trials (CCTs) were electronically searched from MEDLINE (1966 to September 2006), EMBASE (1974 to June 2006), the Cochrane Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2006), CBM (1998 to 2006) and CNKI (1994 to 2006).

Safety of irinotecan/cisplatin versus etoposide/cisplatin for patients with extensive-stage small-cell lung cancer: a metaanalysis.

Purpose: The objective of this study was to evaluate the safety of patients with extensive small-cell lung cancer treated with irinotecan/cisplatin (IP) versus etoposide/cisplatin (EP).

Patients And Methods: This is a metaanalysis of a randomized controlled trial. The main outcome measures for safety were grade 3/4 leukopenia, grade 3 anemia, grade 3/4 thrombocytopenia, grade 3/4 neutropenia, grade 3 vomiting/nausea, grade 3/4 diarrhea, and infection.