A bio-based Janus hydrogel from cellulose and lignin with bilayer structure and asymmetric adhesion for accurate and sensitive human motion monitoring.

Janus hydrogels for human motion monitoring are thriving due to their conductivity, flexibility, anisotropy and self-adhesion, etc. However, most of them face challenges such as complex processes, interlayer detachment, and surface contamination, which degrade their sensing accuracy and sensitivity. Hence, this study proposes a facile strategy using the cellulose and lignin as building blocks to construct a Janus hydrogel for accurate and sensitive sensing.

Ultrafast Thermal Conduction of Phase Change Fiber Enabled by Sheath Confinement-Induced Ordered Orientation of Hydroxylated BNNs.

Phase change fibers (PCFs) are increasingly popular in thermal storage and release applications, such as temperature management. However, a simple but effective integration of thermal conductive materials into PCFs to deliver ultrafast thermal conduction remains a big challenge. Herein, a facile one-pot coaxial wet spinning strategy based on sheath-confinement-induced orientation arrangement of hydroxylated boron nitride nanosheets (BNNs-OH) is proposed to fabricate the high-performance PCFs.

Plasmonic Ultrafast All-Optical Switching with a Superior On-Off Ratio.

Plasmonic ultrafast all-optical switching holds great promise for advancing next-generation optical communication and optical computing technologies. However, achieving subpicosecond all-optical switching with a high on-off ratio remains challenging due to the slow dynamics of electron-phonon scattering in plasmonic materials. Here, we report an innovative method that utilizes the negative signal induced by plasmonic excited hot electrons in the transient spectrum and the positive signal caused by hot electrons excited by off-resonant pumping, both designed at the same wavelength to effectively offset slow dynamics.

Toxicological Assessment of Ketamine in Juvenile Zebrafish ().

This study investigates the toxic effects of ketamine on juvenile zebrafish, driven by increasing concerns over ketamine's prevalence and its potential neurotoxic effects that may disrupt behavior and metabolism. Employing a high-throughput behavior tracking system, the research analyzed the locomotor activity of 6-day post-fertilization (6 dpf) zebrafish exposed to various concentrations of ketamine. The integration of behavioral analysis with metabolic profiling was a notable innovation, as it establishes a comprehensive understanding of ketamine's effects on both acute behavioral inhibition and metabolic responses.

Triptolide combined with salvianolic acid B alleviates CCL-induced liver fibrosis by suppressing the Th17/IL-17A axis.

Liver fibrosis represents a significant public health challenge, with immune dysregulation being a key pathological mechanism involved in its progression. The combined use of triptolide and salvianolic acid B has been demonstrated effective in ameliorating CCL-induced liver fibrosis, but the underlying mechanism remains to be elucidated. In this study, we integrated network pharmacology and experimental validation to uncover the therapeutic mechanisms of the combined use of triptolide and salvianolic acid B.

Advancements in Surgical Therapies for Drug-Resistant Epilepsy: A Paradigm Shift towards Precision Care.

Epilepsy, a prevalent neurological disorder characterized by recurrent seizures, affects millions worldwide, with a significant proportion resistant to pharmacological treatments. Surgical interventions have emerged as pivotal in managing drug-resistant epilepsy (DRE), aiming to reduce seizure frequency or achieve seizure freedom. Traditional resective surgeries have evolved with technological advances, enhancing precision and safety.

Comparing Stability, Gait, and Functional Score after 40-mm Dual-Mobility Hip Arthroplasty to 36-mm Head Hip Arthroplasty in Elderly Hip Fracture Patients.

Backgroud: This study aimed to compare the intraoperative stability and early clinical outcomes of 40-mm diameter dual mobility (DM)-total hip arthroplasty (THA) with 36-mm ceramic head (large head) THA in active elderly patients with hip fractures.

Methods: A prospective randomized controlled trial was conducted from May 2022 to December 2022. Inclusion criteria were as follows: age ≥ 60 years, displaced femoral neck fracture, Koval grade 1 or 2, planned 54-mm acetabular component, and over 1-year follow-up.

Effects of the tobacco-maize relay intercropping pattern on soil nutrients and soil microbial diversity.

The imbalanced soil nutrient status caused by the long-term monoculture of flue-cured tobacco are a concern. The tobacco-maize relay intercropping, widely used in Yunnan, may improve soil nutrients by enhancing the soil microbial community, but this remains unexplored. This study employed high-throughput sequencing technology to examine soil microbial diversity under tobacco monoculture and tobacco-maize relay intercropping, using the varieties Hongda and K326, respectively.

Application of modified solidified soil in in-situ backfilling of coal gangue: evaluation of arsenic stabilization effect and mechanism study.

As a typical ecologically fragile area, the Wudong Coal Mine region in Xinjiang generates large accumulations of coal gangue each year, which, in the alkaline soil environment, can easily lead to significant leaching and accumulation of As. This study developed a stabilizer (CFD) using cement, fly ash, and desulfurized gypsum to modify in-situ soil in the Xinjiang mining area, resulting in a modified solidified soil with excellent geotechnical performance and As stabilization capability. The study results showed that when CFD content exceeded 14.

Enhanced solar hydrogen production via reconfigured semi-polar facet/cocatalyst heterointerfaces in GaN/Si photocathodes.

The development of an efficient and durable photoelectrode is critical for achieving large-scale applications in photoelectrochemical water splitting. Here, we report a unique photoelectrode composed of reconfigured gallium nitride nanowire-on-silicon wafer loaded with Au nanoparticles as cocatalyst that achieved an impressive applied bias photon-to-current efficiency of 10.36% under AM 1.

Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration.

Periodontal disease is a highly prevalent disease worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal disease can achieve good control of inflammation, it is difficult to regenerate the periodontal supporting tissues to achieve a satisfactory therapeutic effect. In recent years, due to the good tissue regeneration ability, the research on Mesenchymal stromal/stem cells (MSCs) and MSC-derived exosomes has been gradually deepened, especially its ability to interact with the microenvironment of the body in the complex immunoregulatory network, which has led to many new perspectives on the therapeutic strategies for many diseases.

Surface Modification of 3D Biomimetic Shark Denticle Structures for Drag Reduction.

Shark skin features superhydrophilic and riblet-textured denticles that provide drag reduction, antifouling, and mechanical protection. The artificial riblet structures exhibit drag reduction capabilities in turbulent flow. However, the effects of the surface wettability of shark denticles and the cavity region underneath the denticle crown on drag reduction remain insufficiently explored.

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy.

Sepsis is a serious and life-threatening condition, which can lead to organ failure and death clinically. Abnormally increased cell-free DNA (cfDNA) and inflammatory cytokines are involved in the development and progression of sepsis. Thus, cfDNA clearance and down-regulation of inflammatory factors are essential for the effective treatment of sepsis.

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential.

Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions.

[Effect of electroacupuncture on denervated skeletal muscle atrophy in rats based on p38 MAPK signaling pathway].

Objective: To assess the impacts of electroacupuncture (EA) on the gait, oxidative stress, inflammatory reaction, and protein degradation in the rats of denervated skeletal muscle atrophy, and explore the potential mechanism of EA for alleviating denervated skeletal muscle atrophy.

Methods: Forty male SD rats, 8 weeks old, were randomly assigned to a sham-surgery group, a model group, an EA group, and a p38 MAPK inhibitor group, with 10 rats in each group. The right sciatic nerve was transected to establish a rat model of denervated skeletal muscle atrophy in the model group, the EA group and the p38 MAPK inhibitor group.

Failure analysis and size optimization of CFRP composite single-lap bonded joints based on the influence of multiple parameters.

This paper had conducted tensile shear tests on single-lap joints (SLJs)bonded structures of carbon fiber reinforced resin matrix (CFRP) composite laminates with different overlap lengths, overlap widths, overlap model, adherend material, and adhesive layer thicknesses under two environments: room temperature dry state (RTD) and elevated temperature wet state (ETW). The failure modes were observed, and load-displacement curves were obtained. The microscopic morphology of the fracture surface was observed by scanning electron microscope (SEM).

Development of a web-based high-throughput marker design program: CAPS (cleaved amplified polymorphic sequence) Maker.

Background: Genetic markers are crucial for breeding crops with desired agronomic traits, and their development can be expedited using next-generation sequencing (NGS) and bioinformatics tools. Numerous tools have been developed to design molecular markers, enhancing the convenience, accuracy, and efficiency of molecular breeding. However, these tools primarily focus on genetic variants within short user-input sequences, despite the availability of extensive omics data for genomic variants.

Age at onset mediates genetic impact on disease severity in facioscapulohumeral muscular dystrophy.

Facioscapulohumeral muscular dystrophy type 1 (FSHD1) patients exhibit marked variability in both age at onset (AAO) and disease severity. Early onset FSHD1 patients are at an increased risk of severe weakness, and early onset has been tentatively linked to the length of D4Z4 repeat units (RUs) and methylation levels. The present study explored potential relationships among genetic characteristics, AAO and disease severity in FSHD1.

Fe-Doped 4-Aminophenylacetylene-Derived Red Emissive Polymer Carbon Dots: Synthesis and Anti-Counterfeiting Applications.

Phenylacetylene derivatives serve as typical monomers for polyaddition reactions. In this study, we present a straightforward one-step protocol for synthesizing polyacetylene P0 (undoped), P0.09 (doped with 0.

Discovery of -Phenyl-5-propyl-1-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury.

Acute liver injury is a severe and potentially life-threatening condition. Currently, there are no specific effective treatments available. HDAC6 has been identified as a promising strategy for treating ALI by inhibiting necrosis and inflammation.

The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating.

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release. However, CD163 does not interact with nucleocapsid (N) protein.

MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.

The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted T cells expressing more diverse T cell receptors (TCRs), some with anti-tumor reactivity. However, knowledge of the range of the antigen(s) that can activate diverse MR1-reactive T cells remains incomplete.

Targeting SphK1/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis.

Sepsis is a heterogeneous and imprecise disorder characterized by aberrant response to infection which has been accredited for detrimental impact on immune homeostasis. Recently, macrophage metabolism has been recognized as attractive targets to develop novel immunomodulatory therapy for sepsis research. However, the fine-tuning regulators dictating macrophage functions and the specific mechanisms underlying macrophage metabolic reprogramming remain largely obscure.