[Toxic effects of sublethal acetochlor with sublethal doses on earthworms in soil using multi-endpoints system].

In this study, we examined the toxic effect of sublethal doses of acetochlor (1, 2, 4, 8 mg·kg) on earthworms by exogenous addition. The growth inhibition rate, cytochrome P450 isozymes (CYP1A2, 2C9 and 3A4) activities and the metabolomics were analyzed after seven days of exposure, to infer the toxicity threshold of acetochlor, screen the sensitive biomarkers from the levels of the individual, detoxified enzymes and small molecular metabolites, and elucidate the underlying toxicity mechanism. The results showed that CYP1A2, 2C9 and 3A4 activities were all significantly inhibited, and that the levels of ten metabolites (fructose-6-diphosphate, cytosine monophosphate, uridine monophosphate, adenosine monophosphate, adenosine, xanthine, fumaric acid, dihydroxyglutaric acid, ornithine and 16-hydroxyeicosatetraenoic acid) were significantly decreased by acetochlor exposure.

Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial.

Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis.

Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control-treatment [CT] group and 48 assigned to intensive-treatment [IT] group) and completed the trial.

Effects of simvastatin gel on bone regeneration in alveolar defects in miniature pigs.

Background: Currently, the most commonly used treatment methods for repairing alveolar furcation defects are periodontal guided tissue regeneration (GTR) and bone grafting. The objective of this study was to investigate the effects of simvastatin/methylcellulose gel on bone regeneration in alveolar defects in miniature pigs.

Methods: Alveolar defects were produced in 32 teeth (the third and fourth premolars) of 4 miniature pigs.

[Prevalence and influencing factors of dental erosion among college students].

Objective: To investigate the prevalence and influencing factors of dental erosion among college students in Guangzhou and to provide necessary information for the prevention.

Methods: A total of 1704 16-24-year-old students from six colleges or universities were assessed for dental erosion. Data on the social economical status, eating habits, oral hygiene habits, and other related factors were obtained through questionnaire.

Antitumor effects of a selenium heteropoly complex in K562 cells.

The aim of this study was to investigate the anti-tumor effects and mechanism of the selenium heteropoly compound (C(2)H(10)N(2))(5)(NH(4))(4)H(2)[Se(2)W(10)V(8)O(62)].9H(2)O (SeWV) in K562 cells. The results showed that 0.

[A study on oral health behavior and other related factors between children with high dmft and no caries].

Objective: To explore the risk factors of children with high dmft.

Methods: In suburban of Guangzhou, oral health of 401 3 - 4-year-old children were examined and structured questionnaire were completed by their parents. 120 children with highest number of dmft (dmft > or = 5) and 118 caries-free children were chosen for case-control analysis.

The antitumor effects of selenium compound Na5SeV5O18.3H20 in K562 cell.

With an approach to study the anti-tumor effects and mechanism of selenium compound, we investigated the anti-tumor activity and mechanism of Na5SeV5O18.H20 (NaSeVO) in K562 cells. The results showed that 0.