Effects of exercise based cardiac rehabilitation delivery modes on chronic heart failure: a systematic review and network meta-analysis.

Chronic heart failure (CHF) represents one of the most severe and advanced stages of cardiovascular disease. Despite the critical importance of cardiac rehabilitation (CR) in CHF management, while studies have explored the effectiveness of various CR delivery modes and offered valuable context-specific insights, their relative efficacy remains inconsistent across different patient groups, healthcare environments, and intervention approaches. A clearer understanding requires comprehensive comparisons and in-depth analyses to address these variations.

Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China.

Introduction: Gut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored.

Methods: This nested cohort study aimed to investigate GM alterations before 24 weeks of gestation and their association with GDM. Ninety-three Chinese participants provided fecal samples during the first and second trimesters.

The JNK Signaling Pathway Regulates Seizures Through ENT1 in Pilocarpine-Induced Epilepsy Rat Model.

Objective: The study investigates whether the expression and function of ENT1 can be regulated by inhibiting the JNK signaling pathway, thereby altering the levels of extracellular adenosine and glutamate in neurons, and subsequently affecting the progression of epilepsy.

Methods: The adult male SD rats were randomly divided into four groups: EP + SP600125 group, EP + DMSO group, EP group, and normal control group. The expression levels of ENT1, p-JNK, and JNK in the hippocampus of rats from each experimental group were detected using Western blotting technology.

The Safety and Efficacy of inactivated COVID-19 vaccination in couples undergoing assisted reproductive technology: A prospective cohort study.

Background: The safety of the COVID-19 inactivated vaccine on pregnancy outcomes in couples undergoing assisted reproductive technology remains uncertain due to limited and speculative evidence. Existing studies primarily focus on the vaccination status of females, with scant information available regarding the vaccination status of male partners. Moreover, there is minimal research tracking live birth outcomes.

Characterization of Cardiac Troponin Fragment Composition Reveals Potential for Differentiating Etiologies of Myocardial Injury.

Background: Increased cardiac troponin (cTn) concentrations occur in acute myocardial injury and chronic diseases. Characterization of cTn composition in the circulation may assist in differentiating etiologies of myocardial injury. Our goal was to study cTn composition and kinetics in patients following type 1 myocardial infraction (T1MI), cardiac procedures, and chronic heart diseases to establish the relationship between cTn composition and clinical diagnosis.

Design and Analytical Evaluation of Novel Cardiac Troponin Assays Targeting Multiple Forms of the Cardiac Troponin I-Cardiac Troponin T-Troponin C Complex and Fragmentation Forms.

Background: Current studies suggest that cardiac troponin (cTn) forms in the circulation may vary in different clinical scenarios. Our aim was to design a combination of cTn assays specific to the main cTn forms and to evaluate their analytical performance.

Methods: We developed immunoassays specific for measuring (1) long-cTnT cTnI-cTnT-TnC (ITC) ternary complex, with cTnT in long form without cleavage at the C-terminal amino acids residue 189-223, designated "long-cTnT ITC complex assay;" (2) both the long-cTnT ITC complex plus short-cTnT ITC complex, designated "hs-total ITC complex assay;" (3) the central part of cTnT of both the long-cTnT ITC complex and free cTnT, designated "hs-cTnT assay.

LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1.

Drug resistance and recurrence are still the bottlenecks in the clinical treatment of ovarian cancer (OC), seriously affecting patients' prognosis. Therefore, it is an urgent challenge for OC to be overcome towards precision therapy by studying the mechanism of OC drug resistance, finding new drug resistance targets and developing new effective treatment strategies. In this study, we found that lncRNA LOC730101 played an essential role in attenuating drug resistance in OC.

Research on the mechanism of human-machine security collaboration of miners considering automation trust.

Safety in the coal mining industry is a long-standing issue. With the implementation of intelligent construction in coal mines, humans-machine collaboration is critical to accident prevention. We investigate the psychological dynamics among miners during intelligent construction by developing distinct evolutionary game models for miner security collaboration mechanisms, while also considering the level of trust in automation.

Vicinal Diol Sesquiterpenes from with Neuroprotective Effects in PC12 Cells.

In the ongoing search for new vicinal diol natural products, four new (Migaones A-D, -) and four known (-) vicinal diol sesquiterpenoids were isolated from the branches and leaves of . Their structures were unequivocally determined by comprehensive spectroscopic analyses (HRESIMS, 1D, and 2D NMR), single-crystal X-ray diffraction, electronic circular dichroism calculations, and comparison with existing literature data. All compounds isolated from possess vicinal diol structural units except compound .

Genetic Risk, BMI Status, BMI Change Patterns, and the Risk of Steatotic Liver Disease and Liver Enzyme Elevation in Chinese Adults.

Whether an increased genetic risk of steatotic liver disease (SLD) can be offset by maintaining a healthy weight remains unknown. We aimed to clarify the associations among the body mass index (BMI) and its change patterns with SLD and assess whether genetic susceptibility can modify these associations in Chinese people. A total of 10,091 and 6124 participants from the Health Omics Preventive Examination (HOPE) Program were enrolled in cross-sectional and follow-up analyses, respectively.

Comparisons of the bioavailability of icariin, icariside II, and epimedin C in rats after oral administration of total flavonoids of Epimedium brevicornu Maxim. and its three formulations.

The low bioavailability of insoluble flavonoids in the total flavonoids of Epimedium brevicornu Maxim. (TFE) severely hindered its clinical efficacy exertion. This research attempted to evaluate the promoting effects of pharmaceutical strategies, including nanosuspensions (NS), cyclodextrin inclusion complexes (CD), and solid dispersions (SD), on the oral absorption of active components in TFE.

Neighborhood Racial and Ethnic Composition Typology and Breast Cancer Risk: The Multiethnic Cohort Study.

Living in racially and ethnically segregated neighborhoods may increase the risk of breast cancer. We examined associations between neighborhood racial and ethnic composition typology and incident primary invasive breast cancer risk in a population-based sample of 102,615 African American/Black, Japanese American, Native Hawaiian, Latino, and White females residing in California and Hawaii from the Multiethnic Cohort (MEC) study between 1993-2019. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using multivariable Cox proportional hazards regression.

LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis.

Gastric cancer ranks among the most prevalent malignancies globally, characterized by limited treatment efficacy and high recurrence rates. Effective management of this disease requires a comprehensive understanding of its underlying pathogenic mechanisms. Galectins have emerged as promising targets in gastric cancer therapy, with Galectin-9 (LGALS9) receiving considerable attention in recent years.

Using isotopic lead and strontium in sediments to trace natural and anthropogenic sources in the Bohai Sea.

The containment history in the coastal zone of the Bohai Sea has not been sufficiently traced because of the difficulty in identifying complex sources of pollutants. This study quantitatively identified various sources of Pb and Sr in two tidal flat sediment cores from Bohai Bay (core BB) and Liaodong Bay (core LB) based on their isotope ratios to trace the natural and anthropogenic disturbance history in the Bohai Sea. The results showed that natural inputs of Pb were the main sources for cores BB and LB; however, core LB was more influenced by anthropogenic inputs.

Atomic Zn-N Site-Regulated Donor-Acceptor Catalyst for Boosting Photocatalytic Bactericidal Activity.

Reactive oxygen species (ROS)-mediated photocatalytic antibacterial materials are emerging as promising alternatives for the antibiotic-free therapy of drug-resistant bacterial infections. However, the overall efficiency of photocatalytic sterilization is restricted by the rapid recombination of the charge carriers. Herein, we design an in-plane π-conjugated donor-acceptor (D-A) system (g-CN-Zn-NC), comprising graphitic carbon nitride (g-CN) as the donor and Zn single-atom anchored nitrogen-doped carbon (Zn-NC) as the acceptor.

Liver Elastography-based Risk Score for Predicting Hepatocellular Carcinoma Risk.

Background & Aims: Liver stiffness measurement (LSM) via vibration-controlled transient elastography (VCTE) accurately assesses fibrosis. We aimed to develop a universal risk score for predicting hepatocellular carcinoma (HCC) development in patients with chronic hepatitis.

Methods: We systematically selected predictors and developed the risk prediction model (HCC-LSM) in the HBV training cohort (n = 2,251, median follow-up of 3.

Development of Aegilops comosa and Aegilops caudata-specific molecular markers and fluorescence in situ hybridization probes based on specific-locus amplified fragment sequencing.

As tertiary gene pools of wheat, Aegilops comosa and Ae. caudata contain many excellent genes/traits and gradually become important and noteworthy wild resources for wheat improvement worldwide. However, the lack of molecular markers and cytological probes with good specificity and high sensitivity limits the development and utilization of Triticum aestivum-Ae.

Engineering a Zn-NC electron bridge boosting charge transfer in ZnO/CN Z-scheme heterojunction for efficient photocatalytic disinfection.

Although photocatalytic disinfection can avoid secondary pollution and other shortcomings compared to traditional disinfection methods, its development is seriously hindered by poor charge separation and transfer efficiency. Herein, we design a Zn-NC (single Zn atoms embedded in nitrogen-doped carbon) bridged ZnO/CN Z-scheme heterojunction (ZnO/Zn-NC/CN) with robust interface contact by a multi-interfacial engineering strategy to achieve highly efficient separation and transfer of charge. Experimental and theoretical analyses demonstrate that the tightly integrated interface and excellent electrical conductivity of Zn-NC electron bridges ensure effective transfer of photogenerated charge carriers.

Determination of strobilurin fungicides residual in vegetables based on amino modified magnetic graphene oxide solid phase extraction coupled with GC-MS/MS.

This research investigated the creation and utilization of an amino-functionalized magnetic graphene oxide (Fe₃O₄-NH₂@GO) nanocomposite as a selective sorbent for extracting and identifying strobilurin fungicides (SFs) from vegetable samples. The investigation utilized a method where magnetic solid phase extraction (MSPE) was integrated with Gas chromatography-triple quadrupole mass spectrometer (GC-MS/MS) for analysis. The physicochemical properties of synthesized sorbent were characterized using Scanning electron microscope (SEM) , Fourier infrared transform spectrum (FT-IR) , X Ray Diffraction (XRD), and vibrating sample magnetometry (VSM) techniques.

Isolated Ni Atoms for Enhanced Photocatalytic HO Performance with 1.05% Solar-to-Chemical Conversion Efficiency in Pure Water.

Photocatalytic hydrogen peroxide (HO) production encounters a major impediment in its low solar-to-chemical conversion (SCC) efficiency due to undesired HO product decomposition. Herein, an isolated nickel (Ni) atom modification strategy is developed to adjust the thermodynamic process of HO production to address the challenge. Sacrificial experiments and in situ characterization reveal that HO generation occurs via a highly selective indirect two-electron oxygen reduction reaction.

NiFe Nanoalloy Electrocatalyst as a Coreaction Accelerator for Enhancing Biomarker Electrochemiluminescence Imaging Detection.

The development of coreaction accelerators with excellent performance is crucial for improving electrochemiluminescence (ECL) performance. In this study, a NiFe nanoalloy electrocatalyst (NiFe-NAEC) was used as a coreaction accelerator to promote persulfate activation, resulting in a 44-fold increase in the ECL intensity of flower-like Zn-3,4,9,10-perylenetetracarboxylate (FL-Zn-PTC). Moreover, the synergistic combination of NiFe-NAEC and silver nanoparticles led to a 134-fold increase in the ECL intensity of FL-Zn-PTC, with a 6275% improvement in the ECL efficiency compared with a reference system containing Ru-bpy/KSO.

Acorus tatarinowii alleviates D-galactose-induced Alzheimer's-like disease cognitive impairment and Aβ-induced pericytes dysfunction in mice.

Pericytes regulate cerebral blood flow (CBF) and excess amyloid in the brain. Pericyte dysfunction may contribute to the pathology of Alzheimer's disease (AD). Acorus tatarinowii (AT), a Chinese medicine commonly used to treat AD, protects the central nervous system.

Tailoring ORR Activity in Fe-N-C Catalysts through Phosphorus Incorporation.

Atomically dispersed iron and nitrogen co-doped carbon materials (Fe-N-C) represent promising non-precious metal catalysts for the oxygen reduction reaction (ORR), offering potential alternatives to noble metal-based benchmarks. In our study, we investigated the influence of phosphorus doping on the catalytic activity of Fe-N-C. The experimental research demonstrate that the doping of phosphorus significantly enhances the ORR activity.