Fecal microbiota transplantation mitigates postdieting weight regain in mice by modulating the gut-liver axis.

Background: Dysbiosis of the microbiome is strongly associated with weight rebound after dieting. However, the interactions between the host and microbiome and their relevance to the pathogenesis of post-diet weight rebound remain unclear.

Purpose: This study aimed to evaluate the effects of fecal microbiota transplantation (FMT) on post-diet weight regain and to investigate the underlying mechanisms by which FMT inhibits weight regain.

PM concentration prediction using a whale optimization algorithm based hybrid deep learning model in Beijing, China.

PM is a significant global atmospheric pollutant impacting visibility, climate, and public health. Accurate prediction of PM concentrations is critical for assessing air pollution risks and providing early warnings for effective management. This study proposes a novel hybrid machine learning model that combines the whale optimization algorithm (WOA) with a convolutional neural network (CNN), long short-term memory (LSTM), and an attention mechanism (AM) to predict daily PM concentrations.

Young Adults and Alcohol-Associated Liver Cancer: Incidence and Death from 2000 to 2021.

Background/objectives: The incidence and mortality of early-onset cancers have been rising in recent decades. While epidemiological studies have examined various types of cancer, updated global data on alcohol-attributable primary liver cancer (PLC) in young adults remains limited.

Methods: This study utilized data from the Global Burden of Disease (GBD) study spanning 2000 to 2021 to evaluate the age-standardized incidence, mortality, and corresponding rates of alcohol-attributable PLC among young adults aged 15-49 years.

Spatiotemporal analysis of carbon emission efficiency across economic development stages and synergistic emission reduction in the Beijing-Tianjin-Hebei region.

Exploring regional carbon emission efficiency and its patterns is crucial for promoting a sustainable economy. This study investigated the spatiotemporal variations of carbon emissions and emission efficiency in the Beijing-Tianjin-Hebei region. Night light data was used to estimate carbon emissions, and the Super-EBM model was employed to calculate carbon emission efficiency.

Efficacy and safety of isavuconazole versus voriconazole for the treatment of invasive fungal infections: a meta-analysis with trial sequential analysis.

Background: Isavuconazole has been used to treat invasive fungal infections, however, it is unclear whether the efficacy of isavuconazole is superior to that of voriconazole. The purpose of this meta-analysis was to assess the efficacy and safety of isavuconazole compared to voriconazole in treating invasive fungal infections.

Methods: Electronic databases, including PubMed, EMBASE, Cochrane Library, and Web of Science, were searched to identify relevant studies.

Genetic insights into the shared molecular mechanisms of Crohn's disease and breast cancer: a Mendelian randomization and deep learning approach.

The objective of this study was to explore the potential genetic link between Crohn's disease and breast cancer, with a focus on identifying druggable genes that may have therapeutic relevance. We assessed the causal relationship between these diseases through Mendelian randomization and investigated gene-drug interactions using computational predictions. This study sought to identify common genetic pathways possibly involved in immune responses and cancer progression, providing a foundation for future targeted treatment research.

Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021.

Objective: To explore the increasing incidence of gastrointestinal (GI) cancers and related risk factors in younger patients.

Patient And Methods: We used data from the Global Burden of Disease Study 2021 to assess the incidence, mortality, and disability-adjusted life years (DALYs) for early-onset (age 15 to 49 years) GI cancers, including mortality and DALYs from diabetes mellitus and high body mass index.

Results: In 2021, there were approximately 499,800 incident cases, 285,900 deaths, and 14.

Global burden of HBV-related liver disease: Primary liver cancer due to chronic HBV infection increased in over one-third of countries globally from 2000 to 2021.

Backgrounds Aims: Hepatitis B virus (HBV)-related liver disease ranks as the seventh leading cause of mortality. Despite advances in prevention and treatment, global disparities in the burden of primary liver cancer (PLC) persist. We evaluate global trends in the prevalence, incidence, and death of HBV-related liver disease.

Simulation and prediction of PM2.5 concentrations and analysis of driving factors using interpretable tree-based models in Shanghai, China.

PM2.5 is a critical air pollutant, and understanding its drivers is essential for regional air quality control. This study employed meteorological and pollutant variables to predict PM2.

Nitric oxide synthase inhibitors reduce the formation of neutrophil extracellular traps and alleviate airway inflammation in the mice model of asthma.

Asthma, a widespread chronic inflammatory disease can contribute to different degrees of lung function damage. The objective of this study is to explore the potential effects of nitric oxide synthase (NOS) inhibitors in asthma using mice model induced by ovalbumin (OVA). BALB/c mice were treated with OVA to establish an asthma model.

The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia.

Background: The effect of immunosuppression on clinical manifestations and outcomes was unclear in elderly patients with CAP.

Methods: Elderly hospitalised patients with CAP were consecutively enrolled and were divided into immunocompromised hosts (ICHs) or non-ICHs groups. Clinical manifestations, severity, and outcomes were compared.

Dynamic classification and attention mechanism-based bidirectional long short-term memory network for daily runoff prediction in Aksu River basin, Northwest China.

Inland river runoff variability is pivotal for maintaining regional ecological stability. Daily flow forecasting in arid regions is crucial in understanding water body ecological processes and promoting healthy river ecology. Precise daily runoff forecasting serves as a cornerstone for ecological evaluation, management, and decision-making.

Regularly Arranged Heterogeneous Pores in Gas Separation Membranes Constructed by Cocrystallization of Porous Organic Molecules.

Integrating two or more materials to construct membranes with heterogeneous pore structures is an effective strategy for enhancing separation performance. Regularly arranging these heterogeneous pores can significantly optimize the combined effect of the introduced components. Porous Organic Cages (POCs), an emerging subclass of porous materials composed of discrete molecules, assemble to form interconnected pores and exhibit permanent porosity in the solid state.

Mortality of Gastrointestinal Cancers Attributable to Smoking, Alcohol, and Metabolic Risk Factors, and its Association With Socioeconomic Development Status 2000-2021.

Objective: Gastrointestinal (GI) cancers account for one-third of global cancer mortality, with nearly half being preventable. This study updates the global burden of GI cancers attributed to major risk factors.

Methods: We utilized data from the Global Burden of Disease Study 2021 to examine trends in death and age-standardized death rates related to GI cancers caused by smoking, alcohol, high body mass index (BMI), and high fasting blood glucose (FBG) from 2000 to 2021.

Increased MASH-associated liver cancer in younger demographics.

Background: The incidence of cancer and the prevalence of metabolic disease and metabolic dysfunction-associated steatotic liver disease is increasing in young adults. However, updated global data on metabolic dysfunction-associated steatohepatitis (MASH)-associated primary liver cancer (PLC) in young adults remains scarce.

Methods: This study analyzed data from the Global Burden of Disease study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years rates from MASH-associated PLC in young adults (15-49 y).

Alcohol-Related Liver Disease, Followed by Metabolic Dysfunction-Associated Steatotic Liver Disease, Emerges as the Fastest-Growing Aetiologies for Primary Liver Cancer in the United States.

Objective: Primary liver cancer (PLC) is projected to be the third leading cause of cancer mortality in the United States in 2040. We examine the burden of PLC in the United States, stratified by sex, state and aetiological risk factors.

Methods: Data on PLC prevalence, incidence, death and disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease Study 2021.

Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment.

Hepatocellular carcinoma (HCC) is a major global burden, ranking as the third leading cause of cancer-related mortality. HCC due to chronic hepatitis B virus (HBV) or C virus (HCV) infection has decreased due to universal vaccination for HBV and effective antiviral therapy for both HBV and HCV, but HCC related to metabolic dysfunction associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD) is increasing. Biannual liver ultrasonography and serum α-fetoprotein are the primary surveillance tools for early HCC detection among high-risk patients (e.

Novel approach to achieving net-zero carbon emissions for development and utilization of coal: Principle, methods, and cost estimation.

China's energy mix is coal-dominated; therefore, it is unrealistic for the country to achieve carbon neutrality through complete decarbonization. As the world's largest carbon emitter, achieving global carbon reduction targets necessitates that China develops low-carbon, clean, safe, and efficient coal development and utilization technologies. This study proposes a new low-carbon coal development and utilization method that integrates in-situ conversion mining and mineral carbonation (ICMMC) to realize coal mining and separation, in-situ backfilling, in-situ conversion, energy storage, and carbon sequestration.

Study on the physiological mechanism and transcriptional regulatory network of early fruit development in Gleditsia sinensis Lam. (Fabaceae).

Background: Gleditsia sinensis Lam. (Fabaceae) is a medicinal legume characterized by its spines and pods, which are rich in saponins, polysaccharides, and various specialized metabolites with potential medicinal and industrial applications. The low fruit set rate in artificially cultivated economic forests significantly impedes its development and utilization.

Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021.

Background: To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US).

Methods: We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States.