Tunable Organic-Inorganic p-π-d Electron Conjugation Triggers d-π Hybridization in Quinonized MnO Superlattice toward Ultrastable and High-Rate Zn-MnO Batteries.

Zn-MnO batteries with two-electron transfer harvest high energy density, high working voltage, inherent safety, and cost-effectiveness. Zn as the dominant charge carriers suffer from sluggish kinetics due to the strong Zn-MnO coulombic interaction, which is also the origin of pestilent MnO lattice deformation and performance degradation. Current studies particularly involve H insertion-dominating chemistry, where the long-term cycle stability remains challenging due to the accumulative Zn insertion and structural collapse.

Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024.

Background: Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. This study systematically investigated the research trends associated with glycolysis in PCa through bibliometric analysis.

V6 encoded by mulberry crinkle leaf virus is important for viral DNA replication.

Mulberry crinkle leaf virus (MCLV) is a representative species of the genus Mulcrilevirus in the family Geminiviridae. Here, we identified an additional V6 ORF which embedded within the V4 ORF in the MCLV virion-sense strand. The expression of V6 was confirmed by analyzing the promoter activity of V6 ORF upstream sequences and quantifying the viral DNA accumulation in V6-mutant MCLV-infected tomato plants.

Targeted mitochondrial function for cardiac fibrosis: An epigenetic perspective.

Mitochondria, commonly referred to as "energy factories"of cells, play a crucial role in the function and survival of cardiomyocytes. However, as research on cardiac fibrosis has advanced, mitochondrial dysfunction(including changes in energy metabolism, calcium ion imbalance, increased oxidative stress, and apoptosis)is now recognized as a significant pathophysiological pathway involved in cardiac remodeling and progression, which also negatively affects the function and structure of the heart. In recent years, research focusing on targeting mitochondria has gained significant attention, offering new approaches for treating cardiac fibrosis.

Development of the membrane ceiling method for in vitro spermatogenesis.

Spermatogenesis is one of the most complex processes of cell differentiation and its failure is a major cause of male infertility. Therefore, a proper model that recapitulates spermatogenesis in vitro has been long sought out for basic and clinical research. Testis organ culture using the gas-liquid interphase method has been shown to support spermatogenesis in mice and rats.

Mechanistic evaluation of enhanced graphene toxicity to Bacillus induced by humic acid adsorption.

The extensive application of graphene nanosheets (GNSs) has raised concerns over risks to sensitive species in the aquatic environment. The humic acid (HA) corona is traditionally considered to reduce GNSs toxicity. Here, we evaluate the effect of sorbed HA (GNSs-HA) on the toxicity of GNSs to Gram positive Bacillus tropicus.

High-throughput screening of dual-target inhibitors for SARS-CoV-2 main protease and papain-like protease from Chebulae Fructus: prediction and experimental verification.

Background: The unavoidable propagation of the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has underscored the urgent requirement for efficacious therapeutic agents. The dried fruit of Retz., namely Chebulae Fructus, is widely used for treating bacterial and viral infectious diseases, which was witnessed to perform anti-SARS-CoV-2 activity in recommended Chinese patent medicine.

Unraveling the drivers of optimal stomatal behavior in global C plants: A carbon isotope perspective.

Understanding the drivers of stomatal behavior is critical for modeling terrestrial carbon cycle and water balance. The unified stomatal optimization (USO) model provides a mechanistic linkage between stomatal conductance (g) and photosynthesis (A), with its slope parameter (g) inversely related to intrinsic water use efficiency (iWUE), providing a key proxy to characterize the differences in iWUE and stomatal behavior. While many studies have identified multiple environmental factors influencing g, the potential role of evolutionary history in shaping g remains incompletely understood.

Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication.

RIG-I-like receptors (RLRs)-mitochondrial antiviral signaling protein (MAVS) are crucial for type I interferon (IFN) signaling pathway and innate immune responses triggered by RNA viruses. However, the regulatory molecular mechanisms underlying RNA virus-activated type I IFN signaling pathway remain incompletely understood. Here, we found that protein arginine methyltransferase 7 (PRMT7) serves as a negative regulator of the type I IFN signaling pathway by interacting with MAVS and catalyzing monomethylation of arginine 232 (R232me1) in MAVS.

Development of ion-triggered gel containing ketoconazole/hydroxypropyl-β-cyclodextrin for ocular delivery: and evaluation.

The application of ketoconazole (KET) in ocular drug delivery is restricted by its poor aqueous solubility though its broad-spectrum antifungal activity. The aim of this study is to develop an ion-sensitive gel (ISG) of KET to promote its ocular bioavailability in topical application. The solubility of KET in water was increased by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), then KET-HPβCD inclusion complex (KET-IC) was fabricated into an ion-sensitive ISG triggered by sodium alginate (SA).

Photosynthesis of AuCu nanocluster for photocatalysis in oxidative functionalization of alkynes.

Ligand-protected metal nanoclusters provide an ideal platform for investigating photoredox catalysis. The central challenge is balancing their stability and catalytic activity. Here we show a photochemical reduction-oxidation cascade method for synthesizing an AuCu nanocluster, which features a robust structure and active surface.

[Isongifolene Improves Crohn's Disease-Like Colitis in Mice by Reducing Apoptosis of Intestinal Epithelial Cells].

Objective: To investigate the effect and molecular mechanism of isolongifolene (ISO) on the apoptosis of intestinal epithelial cells and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced Crohn's disease (CD)-like colitis in mice.

Methods: In the animal experiments, mice were randomly assigned to the wild type (WT) group, TNBS group and TNBS+ISO group, with 8 mice in each group. Colitis models of mice were established in the TNBS group and the TNBS+ISO group by rectal injection of TNBS.

Ultrasound-Guided Needling Combined With High- or Low-Energy Extracorporeal Shock Wave Therapy Versus Needling Alone for Calcified Rotator Cuff: A Retrospective Study.

Background: Rotator cuff calcific tendinitis is a common shoulder joint disorder. Nonsurgical treatment methods, including multiple needling and extracorporeal shock wave therapy (ESWT), can effectively treat calcific tendinitis.

Purpose: To evaluate the clinical results and radiological outcomes of treatment with ultrasound-guided needling (UGN) alone versus UGN with high-energy ESWT (UGN-H) or UGN with low-energy ESWT (UGN-L) in patients with calcific tendinitis of the rotator cuff.

m6A epitranscriptomic modification in diabetic microvascular complications.

N6-methyladenosine (m6A) modifications are modulated by m6A methyltransferases, m6A demethylases, and m6A-binding proteins. The dynamic and reversible patterns of m6A modification control cell fate programming by regulating RNA splicing, translation, and decay. Emerging evidence demonstrates that m6A modification of coding and noncoding RNAs exerts crucial effects that influence the pathogenesis of diabetic microvascular complications that include diabetic cardiomyopathy, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diabetic dermatosis.

[Expression and Clinical Significance of Serum HDAC2 in Patients with Acute Myeloid Leukemia].

Objective: To investigate the expression of serum histone deacetylase 2 (HDAC2) in patients with acute myeloid leukemia (AML) and its clinical significance.

Methods: The 150 AML patients who received treatment in our hospital from April 2017 to April 2019 were included as AML group, and further divided into survival group (108 cases) and death group (42 cases) according to their survival status. In addition, 100 health individuals undergoing health examination in the same period were included as control group.

Co-deposition of Ni-Mo alloy film catalysts for hydrogen evolution from an ethylene glycol system.

Owing to the depletion of renewable energy sources, manufacturing stable, efficient and economical non-noble electrode materials for the hydrogen evolution reaction (HER) through electrochemical water splitting is a promising avenue. In this work, Ni-Mo alloy films containing different Mo concentrations were synthesized potentiostatic technique, and the mechanism of Ni and Mo co-deposition in an ethylene glycol system (EG) was recorded. The co-deposition mechanism of Mo and Ni in the EG shows that the existence of Ni can facilitate the reduction of Mo, while Mo can impede the reduction of Ni.

Identification of Powdery Mildew Resistance-Related Genes in Butternut Squash ().

Powdery mildew infection is a significant challenge in butternut squash () production during winter in Hainan, China. The tropical climate of Hainan promotes powdery mildew infection, resulting in substantial yield losses. By utilizing transcriptome and genome sequencing data, SNPs and potential genes associated with powdery mildew resistance in butternut squash were identified.

Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial.

Newly diagnosed patients with high-risk acute graft-versus-host disease (aGVHD) often experience poor clinical outcomes and low complete remission rates. Ruxolitinib with corticosteroids showed promising efficacy in improving response and failure free survival in our phase I study. This study (ClinicalTrials.

Tumour-pleura relationship on computed tomography (CT) provides effective risk stratification for peripheral pulmonary nodules with Lung Imaging Reporting and Data System (Lung-RADS) score of 4X.

Background: Pulmonary nodules with Lung Imaging Reporting and Data System (Lung-RADS) 4X are of greater clinical significance, and accurate differentiation of pathological types and visceral pleural invasion (VPI) of Lung-RADS 4X peripheral pulmonary nodules before treatment can aid in stratification. This study set out to investigate whether the tumour-pleura relationship on computed tomography (CT) can provide effective risk stratification for peripheral pulmonary nodules with Lung-RADS 4X.

Methods: This was a single institution, retrospective study of 482 consecutive patients with Lung-RADS score 4X, who were pathologically diagnosed with tuberculous granuloma and adenocarcinoma from January 2019 to December 2023.

Synergistic contributions of plant growth-promoting rhizobacteria and exogenous fulvic acid to enhance phytoremediation efficiency of perfluorooctanoic acid (PFOA)-contaminated soils: Boosting PFOA bioavailability and elevating pak choi tolerance.

Perfluorooctanoic acid (PFOA), a synthetic perfluoroalkyl compound, has caused extensive soil contamination over several decades, posing serious health risks to humans through bioaccumulation in plants and subsequent transfer via the food chain. Due to the durability of PFOA in soil and its propensity to migrate and accumulate in plants, phytoremediation has been recognized as an effective remediation method. However, the phytotoxicity of PFOA and the adsorption of PFOA by soil hindered the efficiency of traditional phytoremediation.