Associations between housing quality and sarcopenia among older adults: evidence from China and India.

Objectives: Housing is an important social determinant of health. However, limited studies have focused on the relationship between housing quality and sarcopenia, especially in low- and middle-income countries. This study aims to examine the association between housing quality and sarcopenia in older adults in China and India.

Metabolic Blockade-Based Genome Mining of SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.

Metabolic blockade-based genome mining of the marine sediment-derived SCSIO 07745 led to the discovery of 11 novel aminoquinolinone alkaloids, oxazoquinolinones A-J (-), characterized by an oxazolidone[3,2-α]quinoline-5,8-dione scaffold, and oxazoquinolinone K (), featuring an unprecedented fused 6/6/6/5 tetracyclic core ring system. Additionally, 5 new biosynthetic intermediates or shunt products (-) and a known metabolite sannanine () were identified. Their structures were elucidated by extensive spectroscopic analyses and a comparison of electronic circular dichroism and single-crystal X-ray diffraction.

Development, validation, and clinical application of LC-MS/MS method for simultaneous determination of ibrutinib, zanubrutinib, orelabrutinib, acalabrutinib, and their active metabolites in patients with B-cell lymphoma.

Bruton's tyrosine kinase inhibitors (BTKis) exhibit significant interindividual pharmacokinetics, making therapeutic drug monitoring (TDM) a promising approach for personalized therapy. However, simultaneous quantification of multiple BTKis poses technical challenges. A unified protocol for BTKis detection would be clinically desirable.

The Influence of Multicultural Experience on Attitudes Towards New Foods in the U.S.

Many people are resuming overseas sojourns for tourism, studying abroad, and emigration to foreign countries, contributing to the increasingly diverse population in the United States. Thanks to the growing ethnic and racial diversity, American consumers can access global cuisine and are exposed to different cultures and media influences. Previous studies have highlighted the significance of comprehending the cultures of ethnic minorities and their cultural dimensions in the context of marketing context.

Living Apart Together and Older Adults' Mental Health in the United Kingdom.

Objectives: Living apart together (LAT)-intimate partners living in separate households-is a common partnership type among older adults. Although the mental health benefits of intimate partnerships are widely documented, how LAT relates to older adults' mental health remains understudied.

Methods: Analyzing Waves 3-13 (2011-2023) of the United Kingdom Household Longitudinal Study, we use fixed effects models to examine (1) how older adults' mental health varies with LAT, marriage, cohabitation, and singlehood (never married, widowed, divorced/separated); and (2) how transitions into and out of LAT, compared to marriage and cohabitation, relate to older adults' mental health.

Language in job advertisements and the reproduction of labor force gender and racial segregation.

Job advertisements (ads) represent the first point of contact between employers and job seekers. By signaling characteristics expected of an ideal candidate, job ads "gatekeep" the labor force and configure its composition. Meanwhile, labor force composition can also shape the wording of job ads.

FBLN7 mediates vascular smooth muscle cell phenotype switching and vascular remodeling in hypertension.

Arterial remodeling serves as a pivotal mechanism underlying the development of diseases such as hypertension. Fibulin-7 (FBLN7), an adhesion protein, remains enigmatic regarding its role in these pathological processes. This study aims to explore whether FBLN7 influences vascular remodeling and its underlying mechanisms.

Monitoring long-term cardiac activity with contactless radio frequency signals.

Cardiovascular diseases claim over 10 million lives annually, highlighting the critical need for long-term monitoring and early detection of cardiac abnormalities. Existing techniques like electrocardiograms (ECG) and Holter are accurate but suffer from discomfort caused by body-attached electrodes. While wearable devices using photoplethysmography offer more convenience, they sacrifice accuracy and are susceptible to environmental interference.

Casimir interaction driven by hyperbolic polaritons.

Casimir interaction is an intriguing phenomenon that is induced by electromagnetic quantum fluctuations, which dominates the interaction between microstructures at small separations and is essential for micro- and nano-electromechanical systems (MEMS and NEMS). However, Casimir interaction driven by hyperbolic polaritons remains an unexplored frontier. In this work, we investigate the Casimir interaction between natural hyperbolic material hexagonal boron nitride from the perspective of force distribution with different optical axis orientations for the first time.

Constructing a LiO/LiZn Mixed Ionic Electron Conductive Layer by Ultrasonic Spraying to Enhance Li/Garnet Solid Electrolyte Interface Stability for Solid-State Batteries.

Garnet-type LiGaLaZrO(LGLZO) is believed to be a promising solid electrolyte for solid-state batteries due to its high ionic conductivity, safety, and good stability toward Li. However, one of the most challenges in practical application of LGLZO is the poor contact between Li and LGLZO. Herein, a ZnO layer is prepared on the surface of LGLZO pellet by ultrasonic spraying.

culture filtrate application adds brilliance to the promoting effects of facility warming on winter jujube fruit ripening.

Facility warming can promote fruit ripening of winter jujube ( Mill. cv. Dongzao, DZ) for pre-marketing.

Art for health's sake or health for art's sake: Disentangling the bidirectional relationships between arts engagement and mental health.

Increasing evidence links arts engagement with mental health, but the directionality of the link remains unclear. Applying a novel approach to causal inference, we used nonrecursive instrumental variable models to analyze two waves of data from the United Kingdom Household Longitudinal Study ( = 17,927). Our findings reveal bidirectional causal relationships between arts engagement (arts participation, cultural attendance, and heritage visits) and mental health (GHQ-12 mental distress and SF-12 Mental Component Summary mental well-being).

[Application of exchange transfusion in neonates with severe pertussis and hyperleukocytosis].

Objectives: To investigate the efficacy and safety of exchange transfusion in neonates with severe pertussis.

Methods: A retrospective analysis was performed for the medical data of five neonates with severe pertussis who underwent exchange transfusion in the Department of Neonatology, Hunan Children's Hospital, from August 2019 to March 2024. The clinical characteristics of the patients were summarized, and the efficacy and adverse reactions of exchange transfusion were analyzed.

An ionic-liquid functionalized metal-organic framework and its high performance as a solid electrolyte for lithium-ion conduction.

Crystalline porous metal-organic frameworks (MOFs) have attracted great interest, including in the field of solid-state electrolytes. Herein, we report a new type of solid-state electrolyte based on an MOF matrix and a Li ionic liquid. By covalently bonding the Li ionic liquid (MIMS·LiTFSI) on the stable UiO-67 framework, the obtained crystalline IL-MOF material exhibited high ion conductivities within a wide temperature range (30 °C 1.

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy.

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse event observed in patients receiving paclitaxel, associated with initial pathological changes in the peripheral nervous system, i.e., distal nerves and dorsal root ganglia (DRG).

Controllable Synthesis of Amino-Functionalized Silica Particles via Co-condensation of Tetraethoxysilane and (3-Aminopropyl)triethoxysilane.

Amino-functionalized silica has attracted a great deal of interest due to its high surface reactivity and potential for diverse applications across various fields. While the classical co-condensation method is commonly used to synthesize amino-functionalized silica particles, the mechanism of the reaction between (3-aminopropyl)triethoxysilane (APTES) and tetraethoxysilane under different conditions remains unclear, leading to unexpected self-nucleation or cross-linking between silica particles and consequently hindering rational control over the extent of functionalization. To address this issue, we systematically explored the co-condensation growth mechanism of amino-functionalized silica particles in the Stöber method by investigating the effects of APTES concentration and water content on the hydrolysis and condensation of silanes.

The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project).

Peripheral nervous system (PNS) toxicity assessment in non-clinical safety studies is challenging and relies mostly on histopathological assessment. The present work aims to identify blood-based biomarkers that could detect peripheral neuropathy in rats upon exposure to neurotoxic compounds. Three anticancer agents (oxaliplatin, cisplatin, paclitaxel) and a developmental compound (NVS-1) were assessed in male rats (Wistar Han).