Combination of Tetrazole and 4-Azido-pyrazolotriazine Oxide: Balance of High Nitrogen, Energy, and Safety.

Energetic materials containing a pyrazolotriazine oxide skeleton have the potential for high performance. However, research on the pyrazolotriazine oxide skeleton is very limited due to the inherent ring system instability and limited synthetic approaches. In this paper, APTO and OPTO with a combination of high-nitrogen tetrazole and a promising azido-pyrazolotriazine oxide skeleton have been synthesized.

A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.

Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine-protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely limiting its clinical effectiveness.

Development of a rat airway organoids model for studying chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) poses global health challenges owing to limited treatment options and high rates of morbidity and mortality. Airway organoids have recently become a valuable resource for the investigation of respiratory diseases. However, limited access to clinical tissue samples hinders the use of airway organoids to study COPD.

Construction of 1D Molecular Conductive Wires Through a Polarized Gene Weaving Strategy for Efficient Electromagnetic Wave Absorption.

The growing threat of electromagnetic pollution has become a pressing safety concern. Metal-organic framework (MOF) derivatives are considered ideal candidates for mitigating electromagnetic radiation. However, due to the limitations imposed by complex post-processing and disruption of pristine crystal structures, the mechanisms of electromagnetic wave absorption remain unclear, let alone achieving atomic-level regulation in MOF derivatives.

Facile Synthesis of Bamboo Biochar for Efficient Adsorption of Quinolone Antibiotics: Effects and Mechanisms.

The harmful effects of quinolone antibiotics on ecology and human health have attracted widespread attention. In this study, bamboo biochar synthesized at different pyrolysis temperatures was used to remove quinolone antibiotics (moxifloxacin (MFX), ciprofloxacin (CIP), and ofloxacin (OFLX) as models). The pyrolysis temperature of 700 °C led to a high pore volume and average pore size of biochar.

A Method for the Preparation of Fused Dinitromethyl High-Energy-Density Materials.

This work investigates a simple synthetic method for producing fused dinitromethyl energetic compounds. Fused compound has a high detonation velocity (9358 m s) close to that of the well-known high-energy-density explosive CL-20 (9455 m s), an extremely high density (1.97 cm), and acceptable sensitivity (IS = 8 J).

Host-intestinal microbiota interactions in Edwardsiella piscicida-induced lethal enteritis in big-belly seahorses: Novel insights into the role of Carbohydrate-Active enzymes and host transcriptional responses.

Edwardsiella piscicida-induced lethal enteritis is a major threat to the sustainable development of seahorse aquaculture. The roles of Carbohydrate-Active enzymes (CAZymes) in interactions between the pathogen and the host are poorly understood. In this study, we found that 22 key CAZymes encoded by E.

Prognostic nomogram models for elderly patients with differentiated thyroid carcinoma: A population-based study.

This study aimed to develop and validate a prognostic model for elderly patients with differentiated thyroid carcinoma (DTC) based on various demographic and clinical parameters in order to accurately predict patient outcomes. Patients who were diagnosed with DTC and were over 55 years old between 2010 and 2019 were identified from the Surveillance, Epidemiology, and End Results database. The patients were then randomly divided into a training set and a validation set in a 7:3 ratio, and patients from our center were included as an external validation group.

Comparative efficacy & safety of buparlisib plus fulvestrant, fulvestrant plus dalpiciclib, and ribociclib plus letrozole for postmenopausal, hormone receptor-positive, and HER2-negative breast cancer.

Objectives: This study aimed to compare progression-free survival, overall survival, clinical benefits, and adverse effects in postmenopausal women with hormone receptor-positive and HER2-negative breast cancer who received buparlisib plus fulvestrant against those of women who received dalpiciclib plus fulvestrant, considering ribociclib plus letrozole treatment as the reference standard.

Methods: Women received buparlisib plus fulvestrant (BF cohort, n = 108), dalpiciclib plus fulvestrant (DF cohort, n = 132), or ribociclib plus letrozole (RL cohort, n = 150) until unacceptable toxicity was observed.

Results: A total of 117 (89 %), 80 (74 %), and 84 (56 %) women in the BF, DF, and RL cohorts, respectively, had clinical benefits.

Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma.

Epidermal growth factor receptor wild type lung adenocarcinoma (EGFR LUAD) still has limited treatment options and unsatisfactory clinical outcomes. Ferroptosis, as a form of cell death, has been reported to play a dual role in regulating tumor cell survival. In this study, we constructed a 3-ferroptosis-gene signature, FeSig, and verified its accuracy and efficacy in predicting EGFR LUAD prognosis at both the RNA and protein levels.

Exosomes derived from primary cartilage stem/progenitor cells promote the repair of osteoarthritic chondrocytes by modulating immune responses.

Background: Exosomes derived from primary chondrogenic stem/progenitor cells (CSPCs-EXOs) show promise in cartilage repair due to their immunomodulatory and regenerative properties. However, their specific therapeutic potential in osteoarthritis (OA), especially in modulating immune responses and enhancing chondrocyte function, requires further exploration. This study aims to clarify CSPCs-EXOs' effects on OA by investigating their role in chondrocyte proliferation, migration, inflammation inhibition, and cartilage regeneration.

Corticosteroids for hospitalized patients with severe/critical COVID-19: a retrospective study in Chongqing, China.

Corticosteroids have always been recommended for severe cases of COVID-19. However, the efficacy of treatment with corticosteroids for COVID-19 during the SARS-CoV-2 omicron outbreak in China has not been reported. Clinical data from 406 patients hospitalized for severe/critical COVID-19 from December 2022 to January 2023 at six hospitals in Chongqing were retrospectively analyzed.

Unraveling the immune landscape of lung adenocarcinoma: insights for tailoring therapeutic approaches.

Lung adenocarcinoma (LUAD), a prevalent type of non-small cell lung cancer (NSCLC), was known for its diversity and intricate tumor microenvironment (TME). Comprehending the interaction among human immune-related genes (IRGs) and the TME is vital in the creation of accurate predictive models and specific treatments. We created a risk score based on IRGs and designed a nomogram to predict the prognosis of LUAD accurately.

High-Energy and Thermally Stable Energetic Materials Based on an Azo-Fused Dinitramino Compound.

Here, azo-fused dinitramino energetic compound 5,5'-dinitramino-8,8'-azo-1,2,5-oxadiazolo[3,4-][1,2,4]triazolo[4,3-]pyrazine () and its energetic salts - have been prepared. Azo-fused dinitramino compound exhibits excellent detonation performance ( = 36.13 GPa, and = 9126 m s), which is obviously better than that of RDX ( = 8796 m s, and = 33.

Construction of Nitrogen-Rich Energetic Isomers Containing Multiple Hydrogen Bond Networks.

Nitrogen-rich energetic materials have been the focus of a few studies on their isomers. Novel nitrogen-rich energetic compounds , , and were synthesized through simple steps. The hydrogen bond networks significantly enhanced their properties (, = 290 °C and = 8370 m s; , = 282 °C and = 8392 m s; and , = 272 °C and = 8762 m s), which are superior to their isomers.

Causal association between blood metabolites and abdominal aortic calcification: A bidirectional Mendelian randomization study.

Previous studies have reported correlations between metabolic factors and abdominal aortic calcification (AAC). However, the causal relationship between blood metabolites and AAC remains to be fully explored. We employed bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal relationships between 486 blood metabolites and AAC.

Construction of heterocycle-triazolotriazine framework energetic compounds: towards novel high-performance explosives.

In this paper, three neutral heterocycle-triazolotriazine compounds featuring multiple amino groups and nitro groups were designed and synthesized. Among them, compounds 2 and 6 exhibit high detonation performance ( = 8180 m s, 8650 m s; = 26.40 GPa, 31.