[Development of an animal model of blood stasis syndrome and thrombosis].

Objective: To develop an animal model of thrombosis and blood stasis syndrome in rats by using lipopolysaccharide (LPS) in combination with carrageenan (Ca).

Method: SD rats in control group were randomly divided into control group and model group (LPS/Ca treatment). The rats in model group were firstly treated with Ca ip, and followed by LPS iv sixteen hours later.

[Protective effect of the pretreatment with Chuanxiong-phthalide A on the vascular endothelial cells impaired by the ischemia and reperfusion in isolated rats hearts].

Objective: The aim of this study was to investigate the protective effect of Chuanxiong-pathalide A on the injury of endothelial cell induced by ischemia and reperfusion in isolated rat hearts.

Method: The isolated rat hearts were perfused under constant pressure with Chuanxiong-pathalide A at the concentrations of 0.012 5 mg x mL(-1), 0.

[The clinical efficacy of hemoperfusion in treatment of drug poisoning].

Objective: To investigate the ability of hemoperfusion to remove some drugs or toxin from the body and its clinical efficacy.

Methods: Sixty-nine cases of poisoning due to tetramine or other drugs poisoning in our hospital between July 1990 and December 2003 were studied. Thirty-four patients among them received conventional treatment (including early gastric lavage, hepatoprotection, diuresis or respiratory support), and the remaining were given conventional treatment and hemoperfusion.

A universal microarray for detection of SARS coronavirus.

Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SARS-CoV). There are many point mutations among SARS-CoV genome sequences. Previous studies suggested that the mutations are correlated closely with the SARS epidemic.

[Effect of chaotic and periodic sympathetic nerve stimulation on the activity of chronically compressed rat dorsal root ganglion neurons].

Objective: To study the responses of injured dorsal root ganglion (DRG) neurons to sympathetic nerve stimulation with different time sequences.

Method: In chronically compressed DRG model, the spontaneous activity of the single fiber from injured DRG neurons was recorded, and the responses of DRG neurons to chaotic and periodic electric stimulation of the lumbar sympathetic trunk compared.

Results: Sympathetic-sensory coupling was present in chronically compressed DRG neurons, and the response of DRG neurons increased gradually as the sympathetic stimulating frequency increased from 5 to 20 Hz (P<0.

[Correlation between integrin alpha5beta1 expression in colorectal carcinomas and the biological behavior of the carcinoma cells].

Objective: To study the correlation between the expression of integrin alpha5beta1 in colorectal carcinomas and the differentiation and metastasis of the tumor cells.

Methods: The expression levels of integrin alpha5beta1 were detected immunohistochemically in 81 pairs of cancerous and non-cancerous tissues of patients with colorectal cancer.

Results: The expression of integrin alpha5beta1 was significantly higher in the samples of colorectal carcinomas, than in non-cancerous tissues (P<0.

Relation between responsiveness to neurotransmitters and complexity of epileptiform activity in rat hippocampal CA1 neurons.

Purpose: Our previous works suggested that sensitivity of neurons with chaotic firing patterns to stimuli is significantly greater than that in neurons with periodic firing patterns, which shows that responsiveness of neurons may depend on the complexity of the firing series. This study was performed to determine the relation between responsiveness of the hippocampal CA1 neurons with epileptiform activity (EA) to neurotransmitters and their complexity of firing series.

Methods: Firing series of CA1 neurons were recorded extracellularly in rat hippocampal slice.

[Seizure inhibition by vagal nerve stimulation in rats].

Objective: To study the effect of vagal nerve stimulation in seizure inhibition in rats.

Methods: In rat epileptic models induced by penicillin, electromyogram (EMG), electroencephalogram (EEG) and extracellular electric activity of the cortex were recorded to study the inhibiting effect of vagal nerve stimulation on epilepsy. Results Inhibiting effect of vagal nerve stimulation on epilepsy was observed from the changes in behavior, EMG, EEG and extracellular electric activity of the rats, and this inhibiting effect was enhanced as the frequency for stimulation increased from 5 Hz to 20 Hz.