Low complexity exponential pruning learned digital back-propagation method for fiber nonlinearity mitigation.

Learned digital back-propagation (LDBP) is emerging as a promising solution to mitigate the nonlinear fiber distortions that limit the capacity of optical communications. However, the computational complexity of LDBP, which is affected by dispersion compensation, will increase significantly as optical communications move toward higher baud rates and longer transmission distances. Herein, we propose what we believe to be a novel method called exponential pruning LDBP (EP-LDBP), which is achieved by pruning the redundant LDBP taps with adjustable parameters.

Deposition of Air Pollution-Derived Magnetic Nanoparticles in Human Kidney Revealed by High-Resolution Microstructural Characterization.

Exposure to air pollutants, especially fine particulate matter (PM), has been recognized as a major contributor to the increasing prevalence of kidney diseases. However, until now, evidence for the translocation of airborne nanoparticles (NPs) in the human kidney has been lacking, hindering the understanding of the relationships between PM exposure and kidney diseases. Here, we report the discovery and analysis of airborne magnetite nanoparticles in human kidney stones (with mass concentrations ranging from 363 to 740 ng/g dry tissue weight) by high-resolution microstructural characterization.

Evaluating the effectiveness of integrated traditional Chinese and Western treatment based on symptom grading: a study protocol for a multi-center, randomized controlled trial of patients with depressive disorder.

Background: Approximately one-third of depressed individuals receive treatment globally. The application rate of traditional Chinese medicine (TCM) for treating depression globally remains relatively low. The proposed study presents a pilot trial to evaluate the effectiveness of interventions at different levels in improving depression status in community populations.

Knowledge and attitudes toward [F] fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography among non-radiologist medical staff.

Background: To investigate the current knowledge and attitudes towards [F]fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) among non-radiologist medical staff in China.

Methods: This cross-sectional study was conducted between November 18, 2022, and December 6, 2022, at the First Affiliated Hospital (Southwest Hospital) of the Army Medical University (Third Military Medical University) among non-radiologist staff (medical, nursing, and others). The questionnaire survey (Cronbach's α = 0.

In-Sensor Computing with Visual-Tactile Perception Enabled by Mechano-Optical Artificial Synapse.

In-sensor computing paradigm holds the promise of realizing rapid and low-power signal processing. Constructing crossmodal in-sensor computing systems to emulate human sensory and recognition capabilities has been a persistent pursuit for developing humanoid robotics. Here, an artificial mechano-optical synapse is reported to implement in-sensor dynamic computing with visual-tactile perception.

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration.

Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, and the molecular mechanisms underlying neurodegeneration are unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset neurodegeneration of retinal ganglion cells (RGCs), optic nerve (ON), and spinal cord motor neurons, preceded by a decrease of axonal mitochondria in mice. We discover that OPTN directly interacts with both microtubules and the mitochondrial transport complex TRAK1/KIF5B, stabilizing them for proper anterograde axonal mitochondrial transport, in a C-terminus dependent manner.

Discovery of highly potent dual GSPT1/BRD4 degraders with anti-AML activity.

Translational readthrough (TR) regulation has emerged as a promising therapeutic strategy for cancer treatment. Utilizing a constructed monoclonal cell line AG-9, designed for screening compounds that induce TR, we identified a BRD4-targeted PROTAC molecule, dBET57, that promotes TR by degrading GSPT1. Notably, dBET57 exhibited significant antiproliferative activity against acute myeloid leukemia (AML) and non-Hodgkin lymphoma (NHL) cells across a diverse panel of tumor cell lines.

Force-Triggered Non-Volatile Multilevel Mechano-Optical Memory System for Logic Computation and Image Recognition.

In the big data era, sensing multi-modal information in memory is highly demanded for the sake of artificial intelligence applications to overcome the limitations of the von Neumann architecture. Different from traditional sensing methodologies, mechanoluminescence (ML) materials, which emit light in response to mechanical force without any external power supply, present intriguing prospects for technological developments. However, most of the ML materials only demonstrate instantaneous luminescence, severely hampering the exploitation of ML in sophisticated applications where non-volatile control is indispensable.

Designing Ultra-Narrow-Band Red Phosphor via Oxygen Vacancy Engineering for Transparent Display Application.

Narrow-band red phosphors have been crucial in enabling energy-efficient and wide color gamut display technologies. Developing novel red phosphors with narrower FWHM and suitable positions is still an urgent demand. Herein, a nanorod-shaped NbO:Pr phosphor, featuring a single ultra-narrow-band red emission at 612 nm with FWHM of only 19 nm, is reported.

MMP19 in vascular smooth muscle cells protects against thoracic aortic aneurysm and dissection via the MMP19/Aggrecan/Wnt/β-catenin axis.

Background: Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening cardiovascular event characterized by high mortality rates. Previous studies have shown that matrix metalloproteinases 19 (MMP19) was involved in TAAD formation, while the detailed role of MMP19 in TAAD pathogenesis and underlying mechanism remain unclear.

Methods: To investigate the role of MMP19 in the progression of TAAD, we generated global Mmp19 knockout mice, as well as VSMCs (vascular smooth muscle cells)-specific Mmp19 knockdown mice, and established a BAPN-induced TAAD model.

Mitoxantrone hydrochloride liposome injection for the treatment of Recurrent/Metastatic head and neck squamous cell Carcinoma: A Multicenter, Open-label, Single-arm, phase 1b study.

Background: Mitoxantrone hydrochloride liposomes (PLM60) have been approved for the treatment of relapsed/refractory peripheral T-cell lymphoma (PTCL) in China. This study evaluated the safety and efficacy of PLM60 in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).

Methods: Patients with histologically confirmed HNSCC (including nasopharyngeal carcinoma (NPC)) were enrolled.

Ultrasound Evaluation of the Short-Term Impact of Sleeve Gastrectomy on Common Carotid Artery Structure and Lower Limb Arterial Hemodynamics in Patients with Metabolic Syndrome: A Prospective Pilot Study.

Background: To investigate the application value of ultrasound in assessing the short-term impact of sleeve gastrectomy (SG) on common carotid artery (CCA) structure and lower limb arterial hemodynamics in patients with metabolic syndrome (MS).

Methods: Twenty-one patients with MS undergoing SG at our hospital were enrolled as the experimental group, with 29 healthy volunteers as the control group. Ultrasound was employed to measure and compare the lumen diameter (D), adventitial thickness (AT), intima media thickness (IMT), peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI) of bilateral CCA as well as the PSV and early diastolic reverse flow velocity (R) of lower limb arteries including common femoral (CFA), proximal superficial femoral (SFA), middle superficial femoral and popliteal arteries (POA) at baseline and 1 month after SG.

Effects of combined application of nitrogen, phosphorus, and potassium fertilizers on seed yield, seed quality and economic returns of Elymus nutans in alpine region.

The Qinghai-Tibetan Plateau (QTP), one of the most important ecological regions in the world, is experiencing a decline in ecological function as a result of severe grassland degradation. Elymus nutans is one of the ecological grass species for restoring degraded grasslands in QTP. The seed yield and seed quality are often limited by soil nutrients in QTP, so it is very important to optimize the application rates of fertilizer for E.

Room temperature ferroelectricity in monolayer graphene sandwiched between hexagonal boron nitride.

The ferroelectricity in stacked van der Waals multilayers through interlayer sliding holds great promise for ultrathin high-density memory devices, yet mostly subject to weak polarization and cryogenic operating condition. Here, we demonstrate robust room-temperature ferroelectricity in monolayer graphene sandwiched between hexagonal boron nitride layers with a rhombohedral-like stacking (i.e.

Improving panicle blast resistance and fragrance in a high-quality rice variety through breeding.

Introduction: Huruan1212 (HR1212) is well-regarded for its superior eating and cooking quality in the lower reaches of the Yangtze River in China. Still, its high susceptibility to rice panicle blast and lack of fragrance have limited its further spread and utilization. and are two dominant genes known for their stable broad-spectrum resistance against rice blast fungus , while is the crucial gene that regulates rice aroma.

Classification of Strawberry Maturity Stages and Varieties Using Neural Networks Based on Volatile Organic Compounds.

Volatile organic compounds (VOCs) are closely associated with the maturity and variety of strawberries. However, the complexity of VOCs hinders their potential application in strawberry classification. This study developed a novel classification workflow using strawberry VOC profiles and machine learning (ML) models for precise fruit classification.

Development of a novel multi-epitope mRNA vaccine candidate to combat SFTSV pandemic.

Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) is a novel identified pathogen, despite two decades of research on SFTSV, the potential widespread threats pose a significant challenge for researchers in developing new treatment and prevention methods. In this present, we have developed a multi-epitope mRNA vaccine for SFTSV and valid it with in silico methods. We screened 9 immunodominant epitopes for cytotoxic T cells (CTL), 7 for helper T cells (HTL), and 8 for Linear B-cell (LBL) based on promising candidate protein Gn, Gc, Np, and NSs.

Unveiling the Origin of Copper Accumulation in Plasma with Aging.

Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues.

LINC01305 and LAD1 Co-Regulate CTTN and N-WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis.

Esophageal squamous cell carcinoma (ESCC) is prone to metastasis and is a leading cause of mortality. The cytoskeleton is closely related to cell morphology and movement; however, little research has been conducted on ESCC metastasis. In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds to LINC01305 for co-regulating the level of modulating cortactin proteins (CTTN) and neuronal Wiskott-Aldrich syndrome protein (N-WASP) phosphorylation, which mediates cytoskeletal reorganization and affects the metastasis of ESCC cells.

Multi-Physical Lattice Metamaterials Enabled by Additive Manufacturing: Design Principles, Interaction Mechanisms, and Multifunctional Applications.

Lattice metamaterials emerge as advanced architected materials with superior physical properties and significant potential for lightweight applications. Recent developments in additive manufacturing (AM) techniques facilitate the manufacturing of lattice metamaterials with intricate microarchitectures and promote their applications in multi-physical scenarios. Previous reviews on lattice metamaterials have largely focused on a specific/single physical field, with limited discussion on their multi-physical properties, interaction mechanisms, and multifunctional applications.

DKiS: Decay weight invertible image steganography with private key.

Image steganography, defined as the practice of concealing information within another image. In this paper, we propose decay weight invertible image steganography with private key (DKiS). This model introduces two major advancements into current invertible image steganography: (1) Decay Weight Mechanism: For the first time, we introduce a decay weight mechanism to regulate the transfer of non-essential or 'garbage' information from the secret to the host pipeline.

Engineering silica nanocoated whole-cell asymmetric biocatalyst for efficient preparation of a key chiral intermediate of (S)-Rivastigmine.

In our previous study, the whole cells containing an aldo-keto reductase (yhdN) and glucose dehydrogenase (GDH) were constructed and applied in a stereoselective carbonyl reduction reaction to prepare (S)-NEMCA-HEPE, being a key chiral intermediate of (S)-Rivastigmine which is widely prescribed for the treatment of Alzheimer's disease. Although the conversion and enantiomeric excess (e.e.

Development of a novel multi-epitope subunit mRNA vaccine candidate to combat Acinetobacter baumannii.

Acinetobacter baumannii, an opportunistic bacterium prevalent in various environment, is a significant cause of nosocomial infections in ICUs. As the causative agent of pneumonia, septicemia, and meningitis, A. baumannii typically exhibits multidrug resistance and is associated with poor prognosis, thus led to a challenge for researchers in developing new treatment and prevention methods.

A preliminary exploration of establishing a mice model of hypoxic training.

Altitude training has been widely adopted. This study aimed to establish a mice model to determine the time point for achieving the best endurance at the lowland. C57BL/6 and BALB/c male mice were used to establish a mice model of hypoxic training with normoxic training mice, hypoxic mice, and normoxic mice as controls.

Treating myocardial infarction via a nano-ultrasonic contrast agent-mediated high-efficiency drug delivery system targeting macrophages.

Following myocardial infarction (MI), the accumulation of CD86-positive macrophages in the ischemic injury zone leads to secondary myocardial damage. Precise pharmacological intervention targeting this process remains challenging. This study engineered a nanotherapeutic delivery system with CD86-positive macrophage-specific targeting and ultrasound-responsive release capabilities.