The GPR30-Mediated BMP-6/HEP/FPN Signaling Pathway Inhibits Ferroptosis in Bone Marrow Mesenchymal Stem Cells to Alleviate Osteoporosis.

Dysregulated iron metabolism-induced ferroptosis is considered a key pathological mechanism in the development of osteoporosis (OP). G protein-coupled receptor 30 (GPR30, also known as Gper1) is an estrogen-binding receptor that has shown therapeutic benefits in patients with certain degenerative diseases. Moreover, several studies have demonstrated the anti-ferroptotic effects of estrogen receptor activation.

Ferroelectric Tunable Nonvolatile Polarization Detection Based on 2H α-InSe.

The development of polarization photodetectors utilizing two-dimensional materials holds significant promise due to their distinctive properties and potential for high integration. However, a major limitation of most current polarization photodetectors is their lack of polarization tuning capability, which restricts the versatility of individual devices. In this study, a nonvolatile ferroelectric tunable polarization photodetector is explored based on 2H α-InSe.

Room-Temperature Exciton Polaritons in Monolayer WS Enabled by Plasmonic Bound States in the Continuum.

Exciton polaritons formed by the strong coupling between excitons and photons have been extensively studied in transition metal disulfides (TMDs) for their potential to inherit ultralong radiation lifetime and remarkable nonlinearity. Many studies have achieved strong coupling at room temperature. However, the systems in these studies generally lack orderly characteristics and precise controllability, and their tunability also remains rather limited.

A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy.

Background: Progression to castration resistance is the leading cause of death in prostate cancer patients. Long non-coding RNAs (lncRNAs) have recently become a focal point in the regulation of cancer development. However, few lncRNAs associated with castration-resistant prostate cancer (CRPC) have been reported.

Association between allergic diseases and hypertension: Co-occurrence pattern analysis.

The hypertension risk in the co-occurrence of allergic diseases remains largely unknown. We aimed to investigate the association between allergic diseases co-occurrence pattern and hypertension morbidity and mortality, and to evaluate additive interaction effects between allergic diseases. A nationally representative population from the U.

MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.

Chinese hamster ovary (CHO) cells represent the most widely utilized host system for industrial production of high-quality recombinant protein therapeutics. Novel CHO cell line development is achieved through genetic and cellular engineering approaches, effectively addressing limitations such as clonal variation and productivity loss during culture. Previous studies have established that MAT2A inhibition in tumor cells promotes expression of the cyclin-dependent kinase inhibitor p21, inducing antitumor activity.

STar-DETR: A Lightweight Real-Time Detection Transformer for Space Targets in Optical Sensor Systems.

Optical sensor systems are essential for space target detection. However, previous studies have prioritized detection accuracy over model efficiency, limiting their deployment on resource-constrained sensors. To address this issue, we propose the lightweight space target real-time detection transformer (STar-DETR), which achieves a balance between model efficiency and detection accuracy.

Study on the Impact of Diluent Dosages on the Epoxy-Polythiol Self-Healing System.

Self-healing technology is an effective method for enhancing the crack resistance of cement-based composites. This study focuses on the impact of the environmentally friendly diluent C12-14 alkyl glycidyl ether (AGE) on the performance of the epoxy resin-polythiol (rimethylolpropane tris (3-mercaptopropionate), TMPMP) self-healing system, examining core fluidity, microcapsule properties, molecular dynamics, and the mechanical properties of cured products. The results show that as the AGE dosage increases, the particle size distribution of microcapsules becomes more concentrated, and the dispersion of particles is improved.

Modulatory effects of polysaccharide on bone cell dynamics in osteoporosis.

Background: Osteoporosis (OP) is a systemic bone disorder marked by reduced bone mass and disrupted microstructure, leading to higher fracture risk. Epidemiological data from China show a 20.7% prevalence in women and 14.

Chromosome-level genome assembly of the intertidal lucinid clam Indoaustriella scarlatoi.

Lucinidae, renowned as the most diverse chemosymbiotic invertebrate group, functions as a sulfide cleaner in coastal ecosystems and is thus ecologically important. Despite their significance, genomic studies on these organisms have been limited. Here, we present the chromosome-level genome assembly of Indoaustriella scarlatoi, an intertidal lucinid clam.

A 73-Year-Old Man Presenting with Shoulder Muscle Pain and a Diagnosis of Guillain-Barré Syndrome.

BACKGROUND Guillain-Barre syndrome (GBS) commonly presents with motor weakness and neurological symptoms and signs that include loss of tendon reflexes. However, patients with GBS also experience nerve pain (radicular pain) and deep muscle pain. This report is of a 73-year-old man presenting with shoulder muscle pain and a diagnosis of Guillain-Barre syndrome.

Single-molecule mA detection empowered by endogenous labeling unveils complexities across RNA isoforms.

The landscape of N-methyadenosine (mA) on different RNA isoforms is still incompletely understood. Here, in HEK293T cells, we endogenously label the methylated mA sites on single Oxford Nanopore Technology (ONT) direct RNA sequencing (DRS) reads by APOBEC1-YTH-induced C-to-U mutations 10-100 nt away, obtaining 1,020,237 5-mer single-read mA signals. We then trained m6Aiso, a deep residual neural network model that accurately identifies and quantifies mA at single-read resolution.

Circular RNAs in cancer.

Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as a significant focus in RNA research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles in diverse physiological and pathological processes, functioning through mechanisms such as miRNAs or proteins sponging, regulation of splicing and gene expression, and serving as translation templates, particularly in the context of various cancers. The hallmarks of cancer comprise functional capabilities acquired during carcinogenesis and tumor progression, providing a conceptual framework that elucidates the nature of the malignant transformation.

Response of soil organic carbon stocks and soil microbial biomass carbon to natural grassland conversion: A global meta-analysis.

Natural grasslands worldwide are increasingly being converted into other land-use types, such as cropland and forest, thereby impacting soil carbon cycles and stocks. Soil organic carbon (SOC) is essential for regulating soil properties and microbial communities, while microbial biomass carbon (MBC) is the most active fraction of the SOC pool, both of which play pivotal roles in the global carbon cycle. Here, we performed a meta-analysis on 623 and 85 individual observations from 85 peer-reviewed articles to quantitatively evaluate the effect of grassland conversion on SOCS and MBC.

Biosynthesis inhibition of miR-142-5p in a N-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling.

Background: Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP and the current treatment approaches available for its management are limited. Therefore, there is a significant need to address the dearth of effective therapeutic interventions.

Attention-aware differential learning for predicting peptide-MHC class I binding and T cell receptor recognition.

The identification of neoantigens is crucial for advancing vaccines, diagnostics, and immunotherapies. Despite this importance, a fundamental question remains: how to model the presentation of neoantigens by major histocompatibility complex class I molecules and the recognition of the peptide-MHC-I (pMHC-I) complex by T cell receptors (TCRs). Accurate prediction of pMHC-I binding and TCR recognition remains a significant computational challenge in immunology due to intricate binding motifs and the long-tail distribution of known binding pairs in public databases.

Skin microbiota: pathogenic roles and implications in atopic dermatitis.

Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesis and development of AD. Meanwhile, endogenous and external factors contribute to the dysbiosis of skin microbiota in AD.

QUEST#4X: An Extension of QUEST#4 for Benchmarking Multireference Wave Function Methods.

Given a number of data sets for evaluating the performance of single reference methods for the low-lying excited states of closed-shell molecules, a comprehensive data set for assessing the performance of multireference methods for the low-lying excited states of open-shell systems is still lacking. For this reason, we propose an extension (QUEST#4X) of the radical subset of QUEST#4 ( , , 3720) to cover 110 doublet and 39 quartet excited states. Near-exact results obtained by iterative configuration interaction with selection and second-order perturbation correction (iCIPT2) are taken as benchmark to calibrate static-dynamic-static configuration interaction (SDSCI) and static-dynamic-static second-order perturbation theory (SDSPT2), which are minimal MRCI and CI-like perturbation theory, respectively.

SDSPT2s:SDSPT2 with Selection.

As an approximation to SDSCI [static-dynamic-static (SDS) configuration interaction (CI), a minimal MRCI; , , 1481], SDSPT2 [ , , 2696] is a CI-like multireference (MR) second-order perturbation theory (PT2) that treats single and multiple roots in the same manner. This feature permits the use of configuration selection over a large complete active space (CAS) to end up with a much reduced reference space ̃, which is connected only with a small portion (̃) of the full first-order interacting space connected to . The most expensive portion of the reduced interacting ̃ space (which involves three active orbitals) can further be truncated by partially bypassing its generation followed by an integral-based cutoff.

IDH-mutant glioma risk stratification via whole slide images: Identifying pathological feature associations.

This article aims to develop and validate a pathological prognostic model for predicting prognosis in patients with isocitrate dehydrogenase (IDH)-mutant gliomas and reveal the biological underpinning of the prognostic pathological features. The pathomic model was constructed based on whole slide images (WSIs) from a training set ( = 486) and evaluated on internal validation set ( = 209), HPPH validation set ( = 54), and TCGA validation set ( = 352). Biological implications of PathScore and individual pathomic features were identified by pathogenomics set ( = 100).

Modelling the impact and cost-effectiveness of upcoming Zika virus vaccines on congenital Zika syndrome.

Background: Zika virus (ZIKV) continues to circulate in Southeast Asia following the 2015-2016 global epidemic, posing an ongoing risk of importation and disease spread for Singapore, a tropical city-state in the region. The virus remains a threat to pregnant women and their fetuses due to the risk of Congenital Zika Syndrome (CZS). Vaccines currently in development offer hope for reducing ZIKV infections and CZS cases.

Composition and functional diversity of soil and water microbial communities in the rice-crab symbiosis system.

Rice-crab co-culture is an environmentally friendly agricultural and aquaculture technology with high economic and ecological value. In order to clarify the structure and function of soil and water microbial communities in the rice-crab symbiosis system, the standard rice-crab field with a ring groove was used as the research object. High-throughput sequencing was performed with rice field water samples to analyze the species and abundance differences of soil bacteria and fungi.

Global burden of bacterial skin diseases from 1990 to 2045: an analysis based on global burden disease data.

Bacterial skin diseases are a category of inflammatory skin conditions caused by bacterial infections, which impose a significant global disease burden. However, they have not been well assessed or predicted on a global scale. It is necessary to update the estimates and forecast future trends of the global burden of bacterial skin diseases to evaluate the impact of past healthcare policies and to provide guidance and information for new national and international healthcare strategies.

Epidemiology of Congenital Hand Anomalies at a Single Center in Mainland China: An Analysis of 1,415 Cases.

Currently, large-sample epidemiological studies on congenital upper limb differences (CULD) in China are relatively rare. This report presents our centre's experience on the spectrum of diseases and related factors. Information was collected from patients with CULD who underwent surgical treatment at our centre from September 2018 to October 2023.