Composition, physicochemical properties, and anti-fatigue activity of water-soluble okra (Abelmoschus esculentus) stem pectins.

Okra, Abelmoschus esculentus (L.) Moench, an annual herbaceous plant, is widely distributed in tropical and subtropical regions. Water-soluble pectic hydrocolloids from okra stems (HOS) were extracted and purified using polydivinylbenzene HP-20 resins.

Solution-Based Synthesis of Layered Two-Dimensional Oxides as Broadband Emitters.

Preparing transition-metal oxides in their two-dimensional (2D) form is the key to exploring their unrevealed low-dimensional properties, such as the ptype transparent superconductivity, topological Mott insulator state, existence of the condensed 2D electron/hole gas, and strain-tunable catalysis. However, existing approaches suffer from the specific constraint techniques and precursors that limit their product types. Here, we report a solution-based method to directly synthesize KNbO in 2D by an out-of-the-pot growth process at low temperature, which is observed directly in real time.

Years of life lost due to premature death and their trends in people with malignant neoplasm of female genital organs in Shanghai, China during 1995-2018: a population based study.

Background: The increasing aging population has been posing a significant challenge to disease burden in developing countries. In particular, the contribution of population aging to and long term changes of disease burden of malignant neoplasm of female genital organs (MNFGO) have not been quantitatively demonstrated.

Methods: Data were collected from the Shanghai Vital Statistics System of Pudong New Area (PNA).

Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients.

Introduction: The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis.

Methods: This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non-perforated appendicitis were compared.

Genetic landscape and autoimmunity of monocytes in developing Vogt-Koyanagi-Harada disease.

Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder affecting multiple organs, including eyes, skin, and central nervous system. It is known that monocytes significantly contribute to the development of autoimmune disease. However, the subset heterogeneity with unique functions and signatures in human circulating monocytes and the identity of disease-specific monocytic populations remain largely unknown.

sp. nov., from desert gravel soil.

A Gram-stain-negative, aerobic, non-motile, pink-pigmented, coccus bacterium, designated CPCC 101081, was isolated from a gravel soil sample collected from Badain Jara desert, PR China. Growth of the isolate occurred at 10-37 °C and pH 5.0-8.

Enhancing Charge Separation through Oxygen Vacancy-Mediated Reverse Regulation Strategy Using Porphyrins as Model Molecules.

Highly efficient charge separation has been demonstrated as one of the most significant steps playing decisive roles in enhancing the overall efficiency of photoelectrochemical (PEC) processes. In this study, by employing 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin-Ni (NiTCPP) as a prototype, an oxygen vacancy (Vo)-mediated reverse regulation strategy is proposed for tuning hole transfer, which in turn can accelerate the transport of electrons and thus enhancing charge separation. The optimal NiO/NiTCPP system exhibits much higher (≈40 times) photocurrent and longer (≈13 times) lifetime of charge carriers compared with those of pure NiTCPP.

Impacts of pre-oxidation on the formation of disinfection byproducts from algal organic matter in subsequent chlor(am)ination: A review.

Algae cells and algal organic matter (AOM) present in algae impacted source water pose a serious threat to the safety of drinking water. Conventional water treatment processes poorly remove AOM that can transform to harmful disinfection byproducts (DBPs) during ensuing disinfection. This article offers a comprehensive review on the impacts of pre-oxidation on the formation of DBPs from AOM in subsequent chlor(am)ination.

Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis regulating miR-21 in Human Cholangiocarcinoma Cells.

Dihydromyricetin, the most abundant natural flavonoid isolated from Ampelopsis grossedentata, exhibits broad anti-tumor effects. However, the effects of dihydromyricetin on cholangiocarcinoma remain unclear. This study examined the anti-tumor effects of dihydromyricetin in two human cholangiocarcinoma cell lines HCCC9810 and TFK-1, and the underlying mechanism was also investigated.

Glycomics: Immunoglobulin G -Glycosylation Associated with Mammary Gland Hyperplasia in Women.

Mammary gland hyperplasia (MGH) is very common, especially among young and middle-aged women. New diagnostics and biomarkers for MGH are needed for rational clinical management and precision medicine. We report, in this study, new findings using a glycomics approach, with a focus on immunoglobulin G (IgG) -glycosylation.

Classification of probable online social networking addiction: A latent profile analysis from a large-scale survey among Chinese adolescents.

Background And Aims: Problematic online social networking use is prevalent among adolescents, but consensus about the instruments and their optimal cut-off points is lacking. This study derived an optimal cut-off point for the validated Online Social Networking Addiction (OSNA) scale to identify probable OSNA cases among Chinese adolescents.

Methods: A survey recruited 4,951 adolescent online social networking users.

Pharmacokinetics and bioequivalence of a generic empagliflozin tablet versus a brand-named product and the food effects in healthy Chinese subjects.

Objective: The aim of the present study was to assess the bioequivalence of a generic empagliflozin tablet versus a brand-named empagliflozin tablet (Jardiance) and evaluate the food effects on the pharmacokinetics (PK) of empagliflozin in healthy Chinese subjects.

Methods: Forty-eight healthy volunteers were included in this randomized, open-label, crossover, two-period study (fasting:  = 24, fed:  = 24). A single dose of 25-mg generic (or test) or brand-named (or reference) empagliflozin was administered to each subject in a randomized sequence.

Pharmacokinetics and Bioequivalence of 2 Immediate-Release Tofacitinib Tablet Formulations in Chinese Healthy Volunteers Under Fasting and Fed Conditions.

The purpose of this study was to evaluate the bioequivalence of a generic immediate-release tofacitinib tablet versus a brand-named immediate-release tofacitinib tablet under fasting and fed conditions, and the food effect on pharmacokinetic profiles of the both formulations. This randomized, open-label, 2-period, crossover, bioequivalence study included 52 healthy Chinese subjects (fasting cohort: n = 26; fed cohort: n = 26). The subjects were assigned to receive a single 5-mg dose of generic or brand-named tofacitinib.

NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye.

Purpose: Dry eye disease (DED) is a common and multifactor-induced autoimmune ocular surface disease. Environmental factors, such as desiccating stress (DS) and hyperosmolarity, affect the corneal epithelium to induce ocular surface inflammation in DED. We aimed to explore the potential mechanisms by which innate immunity and pyroptosis are initiated in the mucosal epithelium in response to environmental stress.

Review on electrochemical system for landfill leachate treatment: Performance, mechanism, application, shortcoming, and improvement scheme.

Landfill leachate is a type of complex organic wastewater, which can easily cause serious negative impacts on the human health and ecological environment if disposed improperly. Electrochemical technology provides an efficient approach to effectively reduce the pollutants in landfill leachate. In this review, the electrochemical standalone processes (electrochemical oxidation, electrochemical reduction, electro-coagulation, electro-Fenton process, three-dimensional electrode process, and ion exchange membrane electrochemical process) and the electrochemical integrated processes (electrochemical-advanced oxidation process (AOP) and biological electrochemical process) for landfill leachate treatment are summarized, which include the performance, mechanism, application, existing problems, and improvement schemes such as cost-effectiveness.

The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.

Genetic predisposition of human leucocyte antigen (HLA)-DR has been linked to nonresponse to hepatitis B virus (HBV) vaccination. We sought to reveal their effects on chronic infection and evolution of HBV and development of hepatocellular carcinoma (HCC). Genetic polymorphisms at HLA-DR enhancer regions were genotyped in 4588 participants using quantitative PCR.

Development and validation of a LC-MS/MS method for simultaneous determination of TQ-A3326 and its major metabolites in human plasma, urine and feces: application to pharmacokinetic assay.

TQ-A3326 has been developed as a new drug by modifying the structure of daclatasvir with deuterium. The pharmacokinetics (PK) of TQ-A3326 in human remains unclear. The aim of the present study was to establish a LC-MS/MS method to investigate preliminarily the PK characteristics of TQ-A3326 and its major metabolites in healthy Chinese volunteers.

Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma.

Background: The scoring of Ki-67 is highly relevant for the diagnosis, classification, prognosis, and treatment in breast invasive ductal carcinoma (IDC). Traditional scoring method of Ki-67 staining followed by manual counting, is time-consumption and inter-/intra observer variability, which may limit its clinical value. Although more and more algorithms and individual platforms have been developed for the assessment of Ki-67 stained images to improve its accuracy level, most of them lack of accurate registration of immunohistochemical (IHC) images and their matched hematoxylin-eosin (HE) images, or did not accurately labelled each positive and negative cell with Ki-67 staining based on whole tissue sections (WTS).

Research on efficient denitrification system based on banana peel waste in sequencing batch reactors: Performance, microbial behavior and dissolved organic matter evolution.

Nitrate pollution presents a serious threat to the environment and public health. As an excellent heterotrophic denitrification carbon source, banana peel (a kind of agricultural waste) provides a feasible alternative to deal with the persistent high concentrations of nitrate pollution. Although the feasibility and economy of banana peel for denitrification have already been reported, the long-term stability and mechanism were still unclear.

Dual-Channel Luminescent Signal Readout Strategy for Classifying Aprotic/Protic Polar Organic Medium and Naked-Eye Monitoring of Water in Organic Solvents.

Developing a convenient and rapid detection method for water is greatly desirable in the field of chemical industry. Herein, we present a simple and effective strategy combining a fluorescence sensor and a one-to-two fluorescence colorimetric logic operation to monitor water in a wide range of organic media and classify aprotic/protic polar solvents. The dual-emitting luminescent detector was prepared by incorporating a fluorescent dye Rhodamine 6G (R6G) with strong green light emission within a red light-emitting Eu-metal-organic framework (MOF) through the "bottle around ship" method.

Composition and biochemical properties of ale beer enriched with lignans from Baillon (omija) fruits.

To develop a beverage with high antioxidant capacity and desirable sensory characteristics, (omija) fruits were added to ale type beer at different time points of the brewing process. The phenolic compounds contents in beer were found to be dependent at the moment of the addition of omija fruit. Addition of omija fruits at the initiation of boiling imparted highest oxidative stability to beer and resulted in highest total phenolic and flavonoid contents in ale beer (606.

Degradation of nitrogen-containing refractory organic wastewater using a novel alternating-anode electrochemical system.

This study presented a novel alternating-anode electrochemical system (AAES) based on single electrolytic cell for the treatment of nitrogen-containing refractory organic wastewater (NOW). The core of AAES lies in the alternating working of iron anode and DSA anode to integrate different electrochemical processes. The biologically treated landfill leachate (BTLL) was selected as a practical NOW for assessing the performance of AAES.

Degradation of -nitrophenol by nano-pyrite catalyzed Fenton reaction with enhanced peroxide utilization.

Pyrite (FeS) catalyzed conversion of HO into oxidants is increasingly recognized as a promising Fenton-like process for treating recalcitrant contaminants. However, the underlying mechanism remains unclear, especially for nano-pyrite. The present study explored the potential of a nano-pyrite Fenton system for -nitrophenol oxidation using high energy ball milled nano-pyrite.