Rumor propagation in the framework of evolutionary game analysis.

With the ubiquity of social networks, rumors spread easily, leading to increasing attention on their dissemination. In this context, the spread of rumors is influenced not only by the content of the information itself but also by the behavior of various actors over social networks. To model such a process, we propose a novel rumor propagation interaction model.

Clinical value of systemic immunoinflammatory index in predicting recurrence and metastasis in patients with primary liver cancer.

Background: Primary liver cancer is a highly aggressive neoplasm with high incidence and mortality. Due to the high ability to metastasis, the 5-year survival rate of patients with primary liver cancer is poor.

Aim: To investigate the clinical value of systemic immunoinflammatory index (SII) in predicting recurrence and metastasis after interventional therapy in patients with primary liver cancer.

Plasma microRNA-30a expression in patients with chronic hepatitis B and its application value in the assessment of the severity of liver fibrosis.

Objective: The severity of liver fibrosis (LF) in chronic hepatitis B (CHB) affects the outcome and treatment. We probed plasma miR-30a expression in CHB patients and its value in assessing LF severity.

Methods: This retrospective study included 160 CHB patients and another 98 controls.

FTO/miR-503-5p/USP10 axis regulates neuronal endoplasmic reticulum stress-mediated apoptosis in ischemic stroke.

MiR-503-5p is reported to be implicated in ischemic diseases, including those affecting the heart and brain; however, its specific functions and upstream regulatory mechanisms in acute ischemic stroke (AIS) remain a mystery. To address this, we employed the middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) models to simulate ischemic/reperfusion conditions in vivo and in vitro. MiR-503-5p was found to exacerbate the brain infarct volume, neuronal damage and neurobehavioral impairment in the MCAO/R mice.

Prevention and control strategies for psychrophilic Pseudomonas fluorescens in food: A review.

Psychrophilic Pseudomonas fluorescens can secrete extracellular enzymes, biofilms, and other substances even under refrigeration conditions, which have a negative impact on the quality of dairy products, aquatic products, meat products, produce, and other foods, causing food spoilage and huge economic losses. Therefore, strengthening the prevention and control of psychrophilic P. fluorescens in food is of great significance.

Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.

BackgroundOur previous studies have established that the broad-spectrum anti-epileptic drug lamotrigine (LTG) confers protection against cognitive impairments, synapse and nerve cell damage, as well as characteristic neuropathologies in APP/PS1 mice, a mouse model of Alzheimer's disease (AD). However, the precise molecular mechanisms responsible for this protective effect induced by LTG remain largely elusive.ObjectiveIn this study, we aimed to investigate the mechanisms underlying the beneficial effects of LTG against AD.

"On-off" elution mechanism facilitates the rapid LC/MS/MS-based analysis of peptide antibiotics in human plasma.

Individualized medication with peptide antibiotics, guided by therapeutic drug monitoring, is essential to treat infections caused by multidrug-resistant bacteria. Peptide antibiotics exhibit an "on-off" elution mechanism on a C18 column, leading to adsorption at the column inlet in all-aqueous conditions. Unlike small molecules, column length minimally influences their retention, with longer columns simply broadening peptide antibiotic peaks due to unnecessary post-column volume.

Fundamental absorption bandwidth to thickness limit for transparent homogeneous layers.

Past work has considered the analytic properties of the reflection coefficient for a metal-backed slab. The primary result established a fundamental relationship for the minimal layer thickness to bandwidth ratio achievable for an absorber. There has yet to be establishment of a similar relationship for non-metal-backed layers, and here we present the universal result based on the Kramers-Kronig relations.

Cyclosporin A as an adjunct may enhance the therapeutic effect of interferon alpha-2a in patients with refractory Behcet's uveitis: a retrospective cohort study.

Background: The application of biologic agents has benefited patients with Behcet's uveitis (BU) who do not respond to conventional treatment regimens. However, there is currently no consensus on the optimal treatment regimen of interferon alpha-2a (IFN-α2a) for refractory BU.

Objectives: To evaluate treatment outcomes and safety of IFN-α2a in a large series of refractory BU patients and to explore whether nonbiologic immunomodulatory agents (cyclosporin A) other than corticosteroids should be concomitantly used.

Intergenerational crosstalk of brain-gut axis in parental NdO exposure-induced offspring neurotoxicity and cognitive dysfunction: a mechanistic study.

Introduction: Rare earth elements (REEs) are widely used in plenty of fields. REEs have significant neurotoxicity and it may adversely affect the development of cognitive. For example, neodymium will causing neurological damage through penetrate the blood-brain barrier (BBB).

M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway.

Background: After ischemic stroke (IS), microglia and astrocytes undergo polarization, transforming into a pro-inflammatory phenotype (M1 or A1). According to previous studies, exosomes might play an important role in the interplay between M1 microglia and A1 astrocytes after IS.

Methods: We used the microglial oxygen-glucose deprivation/reperfusion (OGD/R) model and ultracentrifugation to extract M1 microglial exosomes (M1-exos).

Evaluation of the fate of wastewater effluent organic matter in receiving water: Effect of sequential photochemical and biological processes.

Effluent organic matter (EfOM) discharged from wastewater treatment plants (WWTPs) carry substantial risks to river ecosystems. The fate and role of EfOM in the receiving water is affected by its exposure to sunlight and microbial processes, but the extent of these processes remains unclear. In this study, three-phase sequence of irradiation and microbial incubation with EfOM were conducted to compare the behavior of EfOM with that of natural organic matter in receiving rivers (RNOM).

AVE0991 ameliorates dopaminergic neuronal damage in Parkinson's disease through HOTAIRM1/miR-223-3p/α-synuclein axis.

Parkinson's disease (PD) is a prevalent type of neurodegenerative disorder. AVE0991, a non-peptide analogue of Ang-(1-7), by which the progression of PD has been discovered to be ameliorated, but the specific mechanism whereby AVE0991 modulates the progression of PD re-mains unclear. The mice overexpressing human α-syn (A53T) were established to simulate PD pathology, and we also constructed an in vitro model of mouse dopaminergic neurons overexpressing hα-syn (A53T).

Fat mass and obesity-associated protein alleviates cerebral ischemia/reperfusion injury by inhibiting ferroptosis via miR-320-3p/SLC7A11 axis.

Fat mass and obesity-associated protein (FTO) is a demethylase and has recently been found to have a protective effect in acute ischemic stroke (AIS), but the underlying mechanism is unclear to a large extent. New studies have found that the expression of certain miRNAs may be affected by N6-methyladenosine (m6A) levels. Here, using high-throughput sequencing and quantitative polymerase chain reaction, we found miR-320-3p was significantly up-regulated in AIS patients.

Trimethylamine N-Oxide Aggravates Neuro-Inflammation via lncRNA Fendrr/miR-145-5p/PXN Axis in Vascular Dementia Rats.

Purpose: Vascular dementia (VaD) is the second most common dementia in the world. An increasing number of studies have demonstrated the important role of long non-coding RNAs (lncRNAs) in VaD. Our previous investigation demonstrated that Trimethylamine-N-oxide (TMAO) exacerbates cognitive impairment and neuropathological alterations in VaD rats.

Making waves: Harnessing stormwater for resilient water supply - A blueprint for vulnerable continental coasts and oceanic islands.

At the forefront of climate change and natural disasters, small islands like Puerto Rico confront immense challenges in sustaining an adaptive water supply. The challenges are further exacerbated when the islands' constraints, such as geographic isolation, limited resources, aging infrastructure, constrained capacity, and environmental fragility, are compounded. As these issues increasingly impact low-lying continental coasts, home to approximately 40 % of the global population, similar water supply crises have already emerged or are anticipated in these regions.

OS-SSVEP: One-shot SSVEP classification.

It is extremely challenging to classify steady-state visual evoked potentials (SSVEPs) in scenarios characterized by a huge scarcity of calibration data where only one calibration trial is available for each stimulus target. To address this challenge, we introduce a novel approach named OS-SSVEP, which combines a dual domain cross-subject fusion network (CSDuDoFN) with the task-related and task-discriminant component analysis (TRCA and TDCA) based on data augmentation. The CSDuDoFN framework is designed to comprehensively transfer information from source subjects, while TRCA and TDCA are employed to exploit the information from the single available calibration trial of the target subject.

Extensive genomic study characterizing three populations and revealing sp. nov. and sp. nov.

Bacteria within the family show promising potential for applications in various fields, garnering significant research attention. Three Gram stain-negative bacteria, strains CPCC 101601, CPCC 101403, and CPCC 100767, were isolated from diverse environments: freshwater, rhizosphere soil of , and the phycosphere, respectively. Analysis of their 16S rRNA gene sequences, compared with those in the GenBank database, indicated that they belong to the family , with nucleotide similarities of 92.

Improving biodegradability of dissolved organic matter (DOM) in old landfill leachate by electrochemical pretreatment: The effect mechanism of polarity.

Enhancing the biodegradability of old landfill leachate is vital for the efficient treatment or resource utilization of municipal solid waste. Electrochemical pretreatment emerges as a promising technology for transformation of refractory dissolved organic matter (DOM). However, the specific impact of polarity on improving biodegradability of DOM remains unclear.

Utilizing decellularized bio-membranes to optimize histopathological embedding of small tissues.

In recent years, minimally invasive biopsy techniques have been widely used to generate small tissue samples that require processing in clinical pathology. However, small paraffin-embedded tissues are prone to loss due to their small size. To prevent the loss of small tissues, researchers have employed nonbiological embedding materials for preembedding, but this approach can lead to cumbersome experimental procedures and increase the chances of tissue loss.