A large language model for advanced power dispatch.

Power dispatch is essential for providing society with stable, cost-effective, and eco-friendly electricity. However, traditional methods falter as power systems grow in scale and complexity, struggling with multitasking, swift problem-solving, and human-machine collaboration. This paper introduces Grid Artificial Intelligent Assistant (GAIA), a pioneering Large Language Model (LLM) designed to assist with a variety of power system operational tasks, including operation adjustment, operation monitoring, and black start scenarios.

QRICH1 mediates an intracellular checkpoint for CD8 T cell activation via the CARD11 signalosome.

Antigen receptor signaling pathways that control lymphocyte activation depend on signaling hubs and negative regulatory proteins to fine-tune signaling outputs to ensure host defense and avoid pathogenic responses. Caspase recruitment domain-containing protein 11 (CARD11) is a critical signaling scaffold that translates T cell receptor (TCR) triggering into the activation of nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), mechanistic target of rapamycin (mTOR), and Akt. Here, we identify glutamine-rich protein 1 (QRICH1) as a regulator of CARD11 signaling that mediates an intracellular checkpoint for CD8 T cell activation.

 (Violaceae), a new species from central Guangxi, China.

(Violaceae), a new species from Guangxi, China, is established on the basis of morphological and molecular evidence. This new species resembles , but differs from the latter by its stipules margin long fimbriate-dentate (vs. fimbriate-dentate), stolon absent (vs.

Potential mechanism of dietary palm kernel meal effect on muscle tenderness in Tibetan sheep revealed by proteomics and phosphorylated proteomics.

The labe free proteomics technology and 4D labe free phosphorylation proteomics technology was used to systematically analyse the protein expression regulatory mechanisms of muscle tenderness. 59 differentially expressed proteins were screened by proteomic data analysis. Phosphorylated proteomic analysis showed 681 modified peptide levels were changed, of which 235 modified peptide levels corresponded to 132 proteins up-regulated and 446 modified peptide levels corresponded to 253 proteins down-regulated.

Observation on efficacy of autologous platelet rich fibrin combined with ultra-pulsed carbon dioxide laser in the treatment of cancellous bone exposed wounds.

This study is to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) combined with ultra-pulsed carbon dioxide laser in treating cancellous bone-exposed wounds. A total of 65 patients with cancellous bone-exposed wounds were retrospectively analyzed selected. There were 35 cases in ultra-pulsed carbon dioxide laser + PRF group (Laser group, group L), and 30 cases in routine surgical debridement + PRF group (Routine group, group R).

Nickel-Catalyzed Rearranged Alkenylation of 2-Arylaziridines with Aryl Alkenes to Access Allylamines.

The transition-metal-catalyzed ring-opening functionalization of aziridines presents a promising approach for synthesizing structurally complex amines. However, the rearranged functionalization of aziridines poses significant challenges. Herein, we report the first rearranged alkenylation of aziridines with aryl alkenes via Ni-Brønsted acid co-catalysis, leading to the rapid synthesis of a diverse array of allylamines with yields reaching up to 91%.

Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration.

Nucleus pulposus (NP) tissue engineering brings new hope in the repair of intervertebral disc degeneration (IVDD). IVDD is often accompanied by multiscale changes in the mechanical microenvironment, including the changes of mechanical property of collagen fibril, NP tissue, and mechanical instability of spine. In this study, a multiscale mechanically-adapted strategy is proposed to promote NP repair.

Photo-induced dehalogenative deuteration and elimination of alkyl halides enabled by phosphine-mediated halogen-atom transfer.

Dehalogenative deuteration of organic halides is an efficient and straightforward method for incorporating deuterium atoms at specific locations within target molecules. However, utilizing organic halides in photoredox chemistry, particularly unactivated alkyl halides, presents challenges due to their low reduction potentials. In this work, we present a general and effective photoinduced dehalogenative deuteration method for a diverse array of alkyl halides, employing DO as an economical source of deuterium.

Fluorinated Covalent Organic Framework Antifouling Nanofiltration Membranes Through Defect Engineering.

Covalent organic framework (COF) membrane holds great promise in water treat-ment. Improving the antifouling property of COF membrane is critical for practical application while rare investigations have been reported. Grafting fluorinated chains on the COF membrane surface is expected an effective strategy but quite challenging due to the lack of grafting sites.

Mechanism of patulin biodegradation by a reductase from Saccharomyces cerevisiae and its potential application to apple juice.

Bioenzymatic degradation exhibits great potential for mycotoxins removal. So far, little is known about patulin (PAT) degrading enzymes from Saccharomyces cerevisiae. Here, the degradation mechanism of PAT by a free methionine-R-sulfoxide reductase (FRMSR) from S.

Effects and mechanisms of breastmilk stem cells in the treatment of white matter injury in newborn rats.

Background: Breastmilk stem cells (BSCs) have been reported to have potential benefits for infants. However, whether the BSCs could improve brain injury is unknown. A culture system for BSCs was established, and the roles of BSCs in treating white matter injury (WMI) were investigated in our study.

Safety and Efficacy of Intra-Arterial Chemotherapy Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Head and Neck Squamous Cell Carcinoma.

Objective: To investigate the efficacy and safety of local intra-arterial chemotherapy combined with immune checkpoint inhibitors in the treatment of unresectable head and neck squamous cell carcinoma (HNSCC).

Methods: A retrospective analysis was conducted on the clinical data of eight patients diagnosed with unresectable HNSCC at our hospital from January to December 2023. All patients were diagnosed by pathological diagnosis and treated with intra-arterial chemotherapy combined with immune checkpoint inhibitors.

A CE-GAN based approach to address data imbalance in network intrusion detection systems.

As network intrusion behaviors become increasingly complex, traditional intrusion detection systems face limitations, especially with data imbalance. To address this, we introduce the Nash equilibrium concept from game theory into classifier ensemble optimization, enhancing robustness in multi-class classification tasks. Additionally, we propose a network intrusion detection system based on a Conditional Generative Adversarial Network with Conditional Aggregation Encoder-Decoder Structure (CE-GAN) with a conditional aggregation encoder-decoder structure to mitigate data imbalance and improve classifier performance.

A Hierarchical Multimetal Oxides@Graphene Fabric Electrode with High Energy Density and Robust Cycling Performance for Flexible Supercapacitors.

An advanced structure capable of hosting large electrochemical activity with desired balance in ion diffusion kinetics, faradic charge storage, and robust stability is the key to developing high-performance fabric-based electrochemical supercapacitors (FSCs). Herein, we develop a hierarchical multimetal oxides@graphene fabric (Cu-MO@GFF) as a supercapacitor electrode with accelerated ionic diffusion, adsorption energy, faradic redox reaction kinetics, and electrochemical reversibility. As a result, the Cu-MO@GFF presents excellent mass capacitance (534 F g), high rate performance (266 F g at 10 A g), and good cycle performance (96.

Melanoma Cell Adhesion Molecule Plays a Pivotal Role in Proliferation, Migration, Tumor Immune Microenvironment, and Immunotherapy in Colorectal Cancer.

Introduction: MCAM, alternatively referred to as CD146, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. However, its importance in the tumorigenesis of colorectal cancer is still partially understood. Therefore, this study was designed to investigate the significance of MCAM in colorectal cancer.

Aeroallergen Sensitization Patterns and Related Factors in Children With Allergic Rhinitis in Guangzhou.

Certain patterns of children's serum immunoglobulin E (IgE) sensitivity to aeroallergens may offer useful clinical insight into forecasting the course and prognosis of allergic rhinitis (AR). The study aimed to investigate the changes in aeroallergen sensitization patterns in children with AR during the last decade and compare the sensitization pre- and post-coronavirus disease 2019 (COVID-19) pandemic in Children who visited our center. This is a retrospective study, examining the serum IgE of nine aeroallergens from 21,362 children (1-12 years old) from AR who visited Guangzhou Women and Children's Medical Center from June 2013 to June 2023.

VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.

The chronic illness known as oral submucous fibrosis (OSF) results in tissue fibrosis, precancerous lesions, and scarring. It usually manifests itself in the buccal mucosa. It frequently occurs in the buccal mucosa.

Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement.

Mechanisms underlying functional axonal rewiring after adult mammalian central nervous system (CNS) injuries remain unclear partially due to limited models. Here we develop a mouse intracranial pre-olivary pretectal nucleus (OPN) optic tract injury model and demonstrate that Pten/Socs3 knockout and CNTF expression in retinal ganglion cells (RGCs) promotes optic tract regeneration and OPN reinnervation. Revealed by transmission electron microscopy, trans-synaptic labeling, and electrophysiology, functional synapses are formed in OPN mainly by intrinsically photosensitive RGCs, thereby partially restoring the pupillary light reflex (PLR).

Unveiling polycyclic aromatic hydrocarbon pollution dynamics in river-lake sediments: Insights for energy transition.

Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants primarily emitted by heavy industry, while their relationship with light industry has remained largely overlooked. This study quantified 16 priority PAHs in sediments from an urbanized river and its tributaries using gas chromatography coupled with triple quadrupole mass spectrometry, assessing the impact of local light industries. The total sedimentary PAH concentrations ranged from 244 to 24,616 ng/g dw (mean: 2097 ± 2673 ng/g dw), with high molecular weight PAHs predominating.

Study on the Effects of National Volume-Based Procurement of Chemical Drugs on Chinese Patent Medicines: Lipid-Lowering Drugs as an Example.

Background: Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. This study aims to explore the impact of national volume-based procurement (NVBP) on Chinese patent medicines and provide evidence for improving policies and promoting rational drug use.

Methods: The study was based on data from the China National Health Insurance Agency that spanned January 2019 to December 2020.

The reporting quality and methodological quality of dynamic prediction models for cancer prognosis.

Background: To evaluate the reporting quality and methodological quality of dynamic prediction model (DPM) studies on cancer prognosis.

Methods: Extensive search for DPM studies on cancer prognosis was conducted in MEDLINE, EMBASE, and the Cochrane Library databases. The Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) and the Prediction model Risk of Bias Assessment Tool (PROBAST) were used to assess reporting quality and methodological quality, respectively.

Solar evaporator coupled with strong/weak convection and its cascade utilization.

Modulating the macro/nanoarchitecture of evaporators to effectively harness diverse renewable energy sources is of paramount importance for optimizing the performance of solar-driven interfacial evaporation. Inspired by the geometric structure of a windmill, we designed an innovative solar evaporator that expertly harnesses both strong and weak convection. During the purification of heavy metal wastewater, the maximum evaporation rate can reach 4.

A Cu-triggered turn-on fluorescence non-enzymatic probe based on covalent organic framework for the detection of methyl parathion.

Background: Methyl parathion, a potent organophosphorus insecticide, is extensively employed in agriculture and animal husbandry, leading to significant environmental contamination with pesticide residues, posing a grave threat to human health. This compound irreversibly inhibits acetylcholinesterase (AChE) in the human nervous system, resulting in the accumulation of acetylcholine (ACh), which is detrimental. Various enzyme activity-based assays have been explored due to its pathogenic mechanism, yet these methods are fraught with limitations.

Beyond 300-Gb/s optical interconnect over 10-km SSMF at C band enabled by optical vestigial sideband signal.

Using only a linear feed-forward equalizer in the receiver, we experimentally demonstrate a single-wavelength 120 Gbaud PAM4 vestigial sideband (VSB) signal transmission over 10 km standard single-mode fiber (SSMF) at C band under the 7% overhead (OH) hard-decision forward error correction (HD-FEC) bit error rate (BER) threshold. An optical filter is used to generate the VSB signal by optically filtering one sideband signal after the modulator. In order to further increase the data rate, a pre-emphasis equalizer, and a simplified second-order nonlinear equalizer are then employed to combat both the linear and nonlinear distortion introduced in the transmission link.