Insights into cavitation enhancement: Numerical simulation and spectrum analysis of a novel dual-frequency octagonal ultrasonic reactor.

Ultrasonic reactors, widely applied in process intensification, face limitations in their industrial application due to a lack of theoretical support for their structural design and optimization, particularly concerning the uniformity of the cavitation zone. Addressing this gap, our study introduces a novel approach to design a multi-frequency octagonal ultrasonic reactor of capacity 9.5 L through numerical simulation and spectrum analysis.

PRMT1 alleviates isoprenaline-induced myocardial hypertrophy by methylating SRSF1.

Myocardial hypertrophy (MH) is an important factor contributing to severe cardiovascular disease. Previous studies have demonstrated that specific deletion of the protein arginine methyltransferase 1 (PRMT1) leads to MH, but the exact mechanism remains unclear. Serine/arginine-rich splicing factor 1 (SRSF1) affects the development and progression of cardiovascular disease by selectively splicing downstream signaling proteins.

Roles of BMI in mediating the causal effect of obstructive sleep apnea on psoriasis: a two-step mendelian randomization study.

Observational studies have reported an association between obstructive sleep apnea (OSA) and psoriasis. Nonetheless, the presence of a causal relationship within this observed association remains to be confirmed. Consequently, we utilized the Mendelian Randomization (MR) method to assess the causal effects between OSA on psoriasis.

Anatomical categorization of insulo-opercular focal cortical dysplasia and the spatial patterns of stereoelectroencephalography.

Objective: This study was undertaken to anatomically categorize insulo-opercular focal cortical dysplasia (FCD) lesions according to their location and extent, and to summarize corresponding stereoelectroencephalographic (SEEG) patterns to guide preoperative evaluation and surgical planning.

Methods: Patients who underwent epilepsy surgery for insulo-opercular FCD between 2015 and 2022 were enrolled. FCD lesions were categorized into insular, peri-insular, opercular, and complex types based on their location and extent, as ascertained from electroclinical and neuroimaging data.

Laser interstitial thermal therapy in the management of bottom-of-sulcus dysplasia-related epilepsy.

Objective: This study assessed the efficacy and safety of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) versus open surgery (OS) for the treatment of patients with bottom-of-sulcus dysplasia (BOSD)-related epilepsy.

Methods: Twenty-two patients underwent MRgLITT, while 39 underwent OS. Postoperative seizure-free rates were analyzed using Kaplan-Meier curves.

Camera-view supervision for bird's-eye-view semantic segmentation.

Bird's-eye-view Semantic Segmentation (BEVSS) is a powerful and crucial component of planning and control systems in many autonomous vehicles. Current methods rely on end-to-end learning to train models, leading to indirectly supervised and inaccurate camera-to-BEV projections. We propose a novel method of supervising feature extraction with camera-view depth and segmentation information, which improves the quality of feature extraction and projection in the BEVSS pipeline.

Association Between the Weight-Adjusted Waist Index and OSA Risk: Insights from the NHANES 2017-2020 and Mendelian Randomization Analyses.

Background: Obesity is a significant risk factor for obstructive sleep apnea (OSA). The weight-adjusted-waist index (WWI) reflects weight-independent centripetal obesity. Our study aims to evaluate the relationship between WWI and OSA.

Competition between turbulence and thermal blooming of coherent vortex beam array propagating in non-Kolmogorov marine atmosphere.

The competition between turbulence and thermal blooming significantly affects the propagation characteristics of laser beams in the atmosphere. Here, taking the propagation of a vortex beam array in a non-Kolmogorov marine atmosphere as an example, we have quantitatively analyzed the competition between turbulence and thermal blooming. The atmospheric coherence length is adopted to evaluate the turbulence strength, while a modified thermal distortion parameter is developed to evaluate the thermal blooming strength of vortex beam arrays in non-Kolmogorov turbulence.

Suppression of intestinal Ticam1 ameliorated MASH via Akkermansia muciniphila QAA37749.1 mediated betaine transformation.

Background & Aims: Gut inflammation caused by diets could damage the intestinal barrier, which increases the liver exposition to pathogenic substances. Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (Ticam1) is a key molecule in the Toll-like receptors (TLRs) pathway, which is important for the immune defense against pathogens such as bacteria or viruses. In this study, mouse intestinal epithelial cell (IEC) Ticam1 was knocked out to suppress the intestinal inflammation response in metabolic dysfunction-associated steatohepatitis (MASH) to investigate its influence on the development of MASH.

Noninvasive surface-enhanced Raman spectroscopy outperforms combined positive score in predicting sensitivity to neoadjuvant immunotherapy in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma poses a formidable treatment challenge owing to its complex anatomy and essential functions of the organs involved. Neoadjuvant immunotherapies, particularly PD-1 inhibitors, have shown promise in improving patient outcomes. Nevertheless, the ability to accurately predict which patients will benefit from neoadjuvant immunotherapy continues to be a significant hurdle.

CAT Bridge: an efficient toolkit for gene-metabolite association mining from multiomics data.

Background: With advancements in sequencing and mass spectrometry technologies, multiomics data can now be easily acquired for understanding complex biological systems. Nevertheless, substantial challenges remain in determining the association between gene-metabolite pairs due to the nonlinear and multifactorial interactions within cellular networks. The complexity arises from the interplay of multiple genes and metabolites, often involving feedback loops and time-dependent regulatory mechanisms that are not easily captured by traditional analysis methods.

Antioxidative Therapy of Alcoholic Liver Injury by Amorphous Two-Dimensional Cobalt Hydroxide Nanocatalyst.

The intake of excessive ethanol will activate an alternative ethanol metabolic pathway in the liver, resulting in the overproduction of reactive oxygen species (ROS), which further leads to alcoholic liver injury (ALI). Although several molecular antioxidants have been utilized in clinics for treating ALI, their efficacies are still less satisfactory. In this work, a nanocatalytic antioxidation therapeutic strategy is proposed for ALI treatment by constructing amorphous Co(OH) nanosheets with catalytic antioxidative property.

Research on the Electrochemical Impedance Spectroscopy Evolution of Sodium-Ion Batteries in Different States.

Sodium-ion batteries (SIBs) have emerged as a promising alternative to lithium-ion batteries (LIBs) due to the abundant availability of sodium, lower costs, and comparable electrochemical performance characteristics. A thorough understanding of their performance features is essential for the widespread adoption and application of SIBs. Therefore, in this study, we investigate the output characteristics and electrochemical impedance spectroscopy (EIS) features of sodium-ion batteries (SIBs) under various states.

Application of Computational Fluid Dynamic Simulation of Parent Blood Flow in the Embolization of Unruptured A1 Aneurysms.

Objective: To investigate the effect of microcatheter shaping based on the parent artery mainstream line of blood flow simulated using the computational fluid dynamics (CFD) technique on embolization of unruptured aneurysms on the posterior wall of the anterior cerebral artery (ACA) A1 segment.

Methods: Patients with unruptured cerebral aneurysms on the posterior wall of the ACA A1 segment were retrospectively enrolled and treated with endovascular embolization after microcatheter shaping. The clinical, embolization, and follow-up data were analyzed.

Upconversion/Downshifting Circularly Polarized Luminescence over 1200 nm in a Single Nanoparticle for Optical Anticounterfeiting and Information Encryption.

Multimodal upconversion and downshifting circularly polarized luminescent materials hold significant potential for optical anticounterfeiting applications due to their exceptional chiroptical properties. However, constructing these materials within a single emitter remains challenging. In this study, a conceptual model of multimodal upconversion/downshifting circularly polarized luminescence (CPL) is realized within a single nanoparticle.

Identification of Key Genes Controlling Sugar and Organic Acid Accumulation in Wampee Fruit () via Genome Assembly and Genome-wide Association Analysis.

Wampee () is an economically significant subtropical fruit tree widely cultivated in Southern China. To provide high-quality genomic resources for , we report a chromosome-level genome sequence for the "JinFeng" cultivar. The 297.

Regulating Manganese-Site Electronic Structure via Reconstituting Nitrogen Coordination for Efficient Non-Oxygen-Dependent Sonocatalytic Therapy against Orthotopic Breast Cancer.

Sonocatalytic therapy (SCT) has emerged as a promising noninvasive modality for tumor treatment but is hindered by the insufficient generation of ultrasound-induced reactive oxygen species (ROS) and the hypoxic tumor microenvironments. Herein, we fabricated a carbon nanoframe-confined N-coordinated manganese single-atom sonocatalyst with a five-coordinated structure (MnN SA/CNF) using a phthalocyanine-mediated pyrolysis strategy. The precise coordination structure was identified by synchrotron X-ray absorption fine structure analyses.

Effects of dietary factors on hyperuricaemia and gout: a systematic review and meta-analysis of observational studies.

This study aimed to gather the best evidence on the relationship between dietary factors and hyperuricaemia and gout. We searched databases including PubMed, Embase, Cochrane, and Web of Science from database creation to July 2023. Meta-analysis showed that consumption of alcohol (OR: 1.

Toxic effects of ZnO NPs on immune response and tissue pathology in Mytilus galloprovincialis.

Nano-zinc oxide (ZnO NPs), as widely used nanomaterials, are inevitably released into aquatic environments, posing potential threats to aquatic organisms. Mytilus galloprovincialis is a bivalve species sensitive to changes in marine ecological environments, but there has been limited research on its toxicity response to ZnO NPs. Therefore, we selected M.

Precision therapy targeting CAMK2 to overcome resistance to EGFR inhibitors in FAT1-mutated oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer with a high mortality rate in its late stages. One of the major challenges in OSCC treatment is the resistance to epidermal growth factor receptor (EGFR) inhibitors. Therefore, it is imperative to elucidate the mechanism underlying drug resistance and develop appropriate precision therapy strategies to enhance clinical efficacy.