Bioequivalence study of two formulations of afatinib dimaleate tablets in healthy subjects under fasting conditions: A randomized, open-label, single-dose, crossover trial.

Objective: To evaluate the bioequivalence of two different afatinib dimaleate formulations in healthy Chinese subjects under fasting conditions and to assess their pharmacokinetic and safety profiles.

Materials And Methods: This randomized, open-label, 2-period, crossover, bioequivalence study included 32 healthy Chinese subjects. The subjects were assigned to receive a single 40-mg dose of generic or brand-named afatinib dimaleate tablet.

LncRNA TCTN2 Promotes the Malignant Development of Hepatocellular Carcinoma Regulating mIR-1285-3p/ARF6 Axis.

Background: Hepatocellular carcinoma (HCC) is one of the most life-threatening malignant diseases. TCTN2 protein participates in tumorigenesis and development. However, whether lncRNA TCTN2 is associated with HCC pathogenesis remains unclear.

Co-activation of Caspase-1 and Caspase-8 in CMV-induced SGN death by inflammasome-associated pyroptosis and apoptosis.

Cytomegalovirus (CMV) infection causes newborn deafness, and the death of the spiral ganglion neurons (SGNs) is crucial in determining the degree of CMV-related hearing loss. Therefore, understanding the psychopathology of CMV-related SGN loss is important for identifying targets and exploring treatment strategies. In this study, we found that pyroptosis and apoptosis, two inflammasome-related programmed cell death pathways, are involved in CMV-induced SGN death and are mainly regulated by activated caspase-1 and caspase-8.

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1.

MicroRNA-641 (miR-641) was significantly decreased in various cancers, but its roles in endometrial cancer (EC) remain unclear. We explored the influences of miR-641 on the EC cells. In our study, the miR-641 expression was reduced in EC cells.

A screening analysis of the c.176 del 16 mutation responsible for hereditary deafness in a Chinese family.

Objective: To determine whether a new-born child from a family carrying a deafness gene needs cochlear implantation to avoid dysphonia by screening and sequencing a deafness-related gene.

Results: Both screening and sequencing results confirmed that the new born child had a normal gene despite the fact that she has a brother suffering from hearing loss triggered by an allelic c.176 del 16 mutation.

Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss.

Objective: To identify presence of inflammasome activated in mouse cochlea with sensorineural hearing loss (SNHL) caused by cytomegalovirus (CMV) infection.

Method: MCMV was injected into the right cerebral hemisphere in neonatal BALB/c mice at 2000 pfu virus titers. Auditory brainstem responses (ABRs) were tested to evaluate hearing at 21 days.

Novel-designed iliac branch stent graft for internal iliac artery reconstruction during aneurysm repair.

Background: Iliac branch stent grafts (IBSGs) have been used for internal iliac artery preservation during aneurysm repair. However, current available branch iliac stent grafts used in Western countries are not suitable for many patients in Asia because of shorter common iliac arteries (CIA). The aim of this study was to evaluate the efficacy of a novel-designed IBSG in preservation of internal iliac artery during endovascular aneurysm repair in Chinese.

Open and endovascular repair of primary mycotic aortic aneurysms: a 10-year single-center experience.

Purpose: To report early and midterm outcomes after open or endovascular repair of primary mycotic aortic aneurysms treated over a 10-year period in a single center.

Methods: The records of all 12 patients (10 men; 72.9 years, range 59-83) treated for primary mycotic aortic aneurysms from September 2001 to December 2010 were retrospectively reviewed.

Heat shock protein 90 mediates cytoprotection by H₂S against chemical hypoxia-induced injury in PC12 cells.

1. Increasing evidence indicates that hydrogen sulphide (H₂S) may serve as an important biological cytoprotective agent. Heat shock protein (Hsp) 90 can attenuate stress-induced injury.

Rapid mycoplasma culture for the early diagnosis of Mycoplasma pneumoniae infection.

Early diagnosis of Mycoplasma pneumoniae (Mp) plays a pivotal role in its management. We evaluated the role of rapid culture method in early diagnosis of Mp infection and discussed the potential impact factors. A total of 2,600 patients with acute respiratory infection were included, and their pharyngeal swab samples were prepared for Mp rapid culture based on selective Mp fluid culture medium.

[Massage manipulation of supplementing marrow and kneading tendon in treating 30 children with spastic cerebral palsy].

Objective: To observe the therapeutic effect of massage with manipulation of supplementing marrow and kneading tendon (SMKT) on spastic cerebral palsy (CP).

Methods: A total of 60 children with CP were randomly assigned to the treatment group and the control group equally. All were treated with rehabilitation training, but massage with SMKT was carried out additionally for those in the treatment group, five times every week and 3 months as a therapeutic course.