Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis.

Objective: This network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.

Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of AHF between January 1st 2001 and March 31th 2024. The primary outcome measures were N-terminal pro-B type natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), glomerular filtration rate (GFR), blood urea nitrogen, serum creatinine, all-cause mortality within 60 days, and cardiovascular mortality.

Enhancing Sensitivity and Selectivity: Current Trends in Electrochemical Immunosensors for Organophosphate Analysis.

This review examines recent advancements in electrochemical immunosensors for the detection of organophosphate pesticides, focusing on strategies to enhance sensitivity and selectivity. The widespread use of these pesticides has necessitated the development of rapid, accurate, and field-deployable detection methods. We discuss the fundamental principles of electrochemical immunosensors and explore innovative approaches to improve their performance.

Development and external validation of a risk prediction model for depression in patients with coronary heart disease.

Background: Depression is an independent risk factor for adverse outcomes of coronary heart disease (CHD). This study aimed to develop a depression risk prediction model for CHD patients.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES).

Effect of different hypoglycemic drugs and insulin on the risk of new-onset atrial fibrillation in people with diabetes: a network meta-analysis.

Objective: Diabetes is considered a significant risk factor for the development of atrial fibrillation/flutter (AF/AFL). However, there is still insufficient evidence to determine the varying effects of different hypoglycemic drugs (HDs) on the incidence of new-onset AF/AFL in diabetic patients. To address this gap, we conducted a network meta-analysis to investigate whether various HDs have different effects on the risk of new-onset AF/AFL compared with insulin.

Electrical switching properties of AgS/CuP under light and heat excitation.

In this paper, we prepared and investigated the electrical switching behaviors of CuP/AgS heterojunction in the absence/presence of light/heat excitation. The structure exhibited bipolar memristor characteristics. The resistive switching mechanism is due to the formation of Ag conductive filaments and phase transition in CuP.

Long-term effects of different hypoglycemic drugs on carotid intima-media thickness progression: a systematic review and network meta-analysis.

Objective: The progression of carotid intima-media thickness (cIMT) can partially predict the occurrence of future cardiovascular events. This network meta-analysis compared the effects of 14 antidiabetic drugs (acarbose, alogliptin, exenatide, glibenclamide, glimepiride, ipragliflozin, metformin, nateglinide, pioglitazone, rosiglitazone, sitagliptin, tofoglifozin, troglitazone, voglibose) on the progression of cIMT.

Method: PubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of treatment of cIMT with hypoglycemic agents before March 1, 2024.

Association of sleep characteristics with cardiovascular disease risk in adults over 40 years of age: a cross-sectional survey.

Background: The relationship between sleep characteristics and cardiovascular disease (CVD) risk has yet to reach a consistent conclusion, and more research needs to be carried out. This study aimed to explore the relationship between snoring, daytime sleepiness, bedtime, sleep duration, and high-risk sleep patterns with CVD risk.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2015-2018 were collected and analyzed.

Effects of PCSK9 inhibitors on coronary microcirculation, inflammation and cardiac function in patients with CHD after PCI: a protocol for systematic review and meta-analysis.

Introduction: Coronary heart disease (CHD) is one of the common cardiovascular diseases that seriously jeopardise human health, and endothelial inflammation and dyslipidaemia are the initiating links leading to its occurrence. Percutaneous coronary intervention (PCI) is one of the most effective surgical treatments for CHD with narrowed or blocked blood vessels, which can quickly unblock the blocked vessels and restore coronary blood supply. However, most patients may experience coronary microcirculation disorders (CMDs) and decreased cardiac function after PCI treatment, which directly affects the efficacy of PCI and the prognosis of patients.

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications.

Artificial enzymes, as alternatives to natural enzymes, have attracted enormous attention in the fields of catalysis, biosensing, diagnostics, and therapeutics because of their high stability and low cost. Polyoxometalates (POMs), a class of inorganic metal oxides, have recently shown great potential in mimicking enzyme activity due to their well-defined structure, tunable composition, high catalytic efficiency, and easy storage properties. This review focuses on the recent advances in POM-based artificial enzymes.

G-type receptor-like kinase AsNIP43 interacts with rhizobia effector nodulation outer protein P and is required for symbiosis.

In the Rhizobium-Legume symbiosis, the nodulation outer protein P (NopP) effector is one of the key regulators for rhizobial infection and nodule organogenesis. However, the molecular mechanism through which host legume plants sense NopP remains largely unknown. Here, we constructed an nopP deletion mutant of Mesorhizobium huakuii and found that nopP negatively regulates nodulation on Chinese milk vetch (Astragalus sinicus).

Recent Advances in Confining Polyoxometalates and the Applications.

Polyoxometalates (POMs) are widely used in catalysis, energy storage, biomedicine, and other research fields due to their unique acidity, photothermal, and redox features. However, the leaching and agglomeration problems of POMs greatly limit their practical applications. Confining POMs in a host material is an efficient tool to address the above-mentioned issues.

A Germin-Like Protein GLP1 of Legumes Mediates Symbiotic Nodulation by Interacting with an Outer Membrane Protein of Rhizobia.

Rhizobia can infect legumes and induce the coordinated expression of symbiosis and defense genes for the establishment of mutualistic symbiosis. Numerous studies have elucidated the molecular interactions between rhizobia and host plants, which are associated with Nod factor, exopolysaccharide, and T3SS effector proteins. However, there have been relatively few reports about how the host plant recognizes the outer membrane proteins (OMPs) of rhizobia to mediate symbiotic nodulation.

Photoluminescence properties of cuprous phosphide prepared through phosphating copper with a native oxide layer.

Although cuprous phosphide (CuP) has been widely studied and applied in other fields, its photoluminescence (PL) properties are rarely investigated. Herein, we report that CuP can emit near-infrared light at 750 nm. We show that the annealing and the presence of cuprous oxide can enhance the PL emission.

Investigation of photoelectric behaviors of silver sulfide particles in different surroundings.

Silver sulfide (AgS) is a traditional semiconductor material, however, the photoelectric properties of AgS particles under different environments are still lacking. In this paper, we reported the preparation of AgS particles and their photoelectric properties under different environments. Results showed that the photoelectric performance of AgS particles was closely related to the environment.

Icariin inhibits hypoxia/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO-1 signaling pathway.

Myocardial infarction (MI) is caused by the formation of plaques in the arterial walls, leading to a decrease of blood flow to the heart and myocardium injury as a result of hypoxia. Ferroptosis is a crucial event in myocardial injury, and icariin (ICA) exerts protective effects against myocardial injury. Here, we investigated the protective mechanism of ICA in hypoxia/reoxygenation (H/R)-induced ferroptosis of cardiomyocytes.

Efficacy and safety of bloodletting for herpes zoster: A protocol for systematic review and meta-analysis.

Background: The study aims to evaluate the effectiveness and safety of bloodletting therapy for herpes zoster.

Methods: The following electronic databases will be searched from PubMed (1966 to March 2020), the Cochrane Central Register of Controlled Trials (update to March 2020), EMBASE (1980 to March 2020), China National Knowledge Infrastructure (1979 to March 2020), Wan Fang Data (1980 to March 2020), Chinese Scientific Journal Database (1989 to March 2020), Chinese Biomedical Database (1978 to March 2020) and traditional Chinese medicine Literature Analysis and Retrieval Database (1949 to March 2020). All randomized controlled trials without any limitation of blinding or publication language about this topic will be included, exclude cohort studies and case reports.

Highly conductive and transient tracks based on silver flakes and a polyvinyl pyrrolidone composite.

Transient electronics have been widely researched to solve the electronic waste (E-waste) issue. Although various transient materials and devices have been reported, the fabrication technique for transient conductors always uses expensive sputtering or evaporation processes. In this study, a silver flake (AgF) and polyvinyl pyrrolidone (PVP) composite is prepared for conductive and transient tracks.

Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects.

Intrinsically Stretchable, Transient Conductors from a Composite Material of Ag Flakes and Gelatin Hydrogel.

Transient conductors are one of the most important components in transient electronics, which attract great attention because of their environment-friendly and biocompatible characters. To meet the requirement for wearable electronics, good stretchability and mechanical durability are needed for the transient conductors. However, it remains challenging to achieve stretchability and transient behavior simultaneously because of a lack of the proper elastomer.

A dual-function fluorescent probe for Hg (II) and Cu (II) ions with two mutually independent sensing pathways and its logic gate behavior.

A dual-function fluorescent Probe 1 has been synthesized conveniently by coupling rhodamine hydrazone with O-vinyl protected hydroxyl benzaldehyde. Probe 1 was a highly selective and sensitive chemodosimeter for Hg through specific hydrolysis reaction of vinyl ethers with significant fluorescence quenching in CHCN-PBS buffer (3:7, v/v) solution. Meanwhile, Probe 1 showed a ratiometric fluorescent detection of Cu with a remarkable large Stokes shift (150 nm) by the opening of the spirolactam ring in CHCN-PBS buffer (3:7, v/v) solution.

A Bilayer 2D-WS/Organic-Based Heterojunction for High-Performance Photodetectors.

Two-dimensional (2D) tungsten disulfide (WS) has inspired great efforts in optoelectronics, such as in solar cells, light-emitting diodes, and photodetectors. However, chemical vapor deposition (CVD) grown 2D WS domains with the coexistence of a discontinuous single layer and multilayers are still not suitable for the fabrication of photodetectors on a large scale. An emerging field in the integration of organic materials with 2D materials offers the advantages of molecular diversity and flexibility to provide an exciting aspect on high-performance device applications.