Acute stress and multicellular development alter the solubility of the Sup35 ortholog ERF3.

Among sequenced organisms, the genome of is unique in that it encodes for a massive amount of repeat-rich sequences in the coding region of genes. This results in the proteome encoding for thousands of repeat-rich proteins, with nearly 24% of the proteome encoding Q/N-rich regions that are predicted to be prion like in nature. To begin investigating the role of prion-like proteins in , we decided to investigate ERF3, the ortholog of the well-characterized yeast prion protein Sup35.