Re-analysis of single cell and spatial transcriptomics data reveals B cell landscape in gastric cancer microenvironment and its potential crosstalk with tumor cells for clinical prognosis.

Background: At present, immunotherapy has become a powerful treatment for advanced gastric cancer (AGC), but not all patients can benefit from it. According to the latest research, the impact of B cell subpopulations on the immune microenvironment of gastric cancer (GC) is unknown. Exploring whether the interaction between B cells and tumor cells in GC affects the effectiveness of immunotherapy has attracted our interest.

Synthesis of New Isoxazolidine Derivatives Utilizing the Functionality of -Carbonylpyrazol-Linked Isoxazolidines.

Using Ni(II) as the catalyst, electron-deficient 3,5-dimethylacryloylpyrazole olefin was reacted with ,-diarylnitrones alone for 10 min to prepare novel five-member heterocyclic products, 4-3,5-dimethylacryloylpyrazole isoxazolidines with 100% regioselectivity and up to 99% yield. And then, taking these cycloadducts as substrates, six kinds of derivatization reactions, like ring-opening, nucleophilic substitution, addition-elimination and reduction, were studied. Experimental results showed that all kinds of transformations could obtain the target products at a high conversion rate under mild conditions, a finding which provided the basic methods for organic synthesis methodology research based on an isoxazolidine skeleton.

Review of the Real-Time Monitoring Technologies for Lithium Dendrites in Lithium-Ion Batteries.

Lithium-ion batteries (LIBs) have the advantage of high energy density, which has attracted the wide attention of researchers. Nevertheless, the growth of lithium dendrites on the anode surface causes short life and poor safety, which limits their application. Therefore, it is necessary to deeply understand the growth mechanism of lithium dendrites.

Synthesis and Application of 1,8-Naphthalimide Derivatives Fluorescent Probe for Sequential Recognition of Cu and HPO.

A naphthalimide Schiff base fluorescent probe (BSS) was designed and synthesized from 4-bromo-1,8-naphthalic anhydride, and its structure was characterized by HNMR, CNMR, FTIR, and MS. Fluorescence emission spectra showed that probe BSS could realize the "turn-off" detection of Cu in acetonitrile solution, detection process with strong specificity and excellent anti-interference of other metal ions. In the fluorescence titration experiments, fluorescence intensity of BSS showed a good linear relationship with the Cu concentration (0-10 µmol/L), and the detection limit was up to 7.

Synthesis of Coumarinylhydrazone Fluorescent Probe and its Relay Recognition of Cu and HPO.

A novel coumarinylhydrazone fluorescent probe L was designed and synthesized from 4-(diethylamino)salicylaldehyde, its structure was characterized by NMR, IR. Fluorescence emission spectra showed that in ethanol solution, probe L could form a 1:1 complex L-Cu with Cu to realize the "turn-off" detection of Cu with high specificity and sensitivity (3.7 × 10 mol/L).

Synthesis and application of a dual-functional fluorescent probe for sequential recognition of Znand glyphosate.

A novel fluorescent probe QL was designed and synthesized based on Schiff base by 2-hydrazinobenzothiazole to sequentially recognize Zn and glyphosate. The probe QL was capable to detect Zn in DMSO solution via fluorescence enhancement, and exhibited good selectivity and anti-interference ability. The combination mode was 1:2 between probe QL and Zn according to the method of job's plot, and the detection limit of probe QL for Zn was found to be 4.

Is serum zinc status related to gestational diabetes mellitus? A meta-analysis.

Gestational diabetes mellitus (GDM) is a common medical disorder that begins during pregnancy. The present work aimed to investigate the relationship of maternal or foetal circulatory zinc levels with GDM. Related studies were retrieved against the PubMed/Medline, Web of Science, Scopus databases till July 2020.

A Portable Waterproof EEG Acquisition Device for Dolphins.

The acquisition and analysis of EEG signals of dolphins, a highly intelligent creature, has always been a focus of the research of bioelectric signals. Prevailing cable-connected devices cannot be adapted to data acquisition very well when dolphins are in motion. Therefore, this study designs a novel, light-weighted, and portable EEG acquisition device aimed at relatively unrestricted EEG acquisition.

Relationship of Circulating Copper Level with Gestational Diabetes Mellitus: a Meta-Analysis and Systemic Review.

Background And Purpose: Gestational diabetes mellitus (GDM) represents the frequently occurring medical disorder beginning in the process of pregnancy. No consensus has been reached about the relationship of circulating copper content with the risk of GDM. Therefore, the present work carried out a meta-analysis for summarizing epidemiological research regarding the copper level with the GDM risk.

[Chlorogenic acid content comparison of different processed products of Ilex hainanensis Merr].

Objective: To control different processed products of Ilex hainanensis Merr quality.

Methods: Using HPLC to determine chlorogenic acid of Ilex hainanensis Merr. Measure wavelength is 327 nm.