The Story of Dr. Asa G. Yancey and Surgical Innovation in the Face of Discrimination.

Introduction: Dr. Asa G. Yancey published a surgical technique describing a pull - through of normal colon through a cuff of aganglionic colon to treat Hirschsprung disease in 1952, 12 y before Dr.

Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes.

Introduction: Untreated bipolar disorder in pregnancy is associated with adverse maternal and neonatal outcomes. Despite advances in clinical management, there is concern among obstetric providers and patients about the safety of pharmacological agents for the treatment of bipolar disorder in pregnancy. Recent studies have shown atypical antipsychotics and lamotrigine to have a favorable safety profile; however, little information is published on lurasidone.

Adsorption of difluoromethane (HFC-32) and pentafluoroethane (HFC-125) and their mixtures in silicalite-1: An experimental and Monte Carlo simulation study.

Hydrofluorocarbons are a class of fluorinated molecules used extensively in residential and industrial refrigeration systems. This study examines the potential of using adsorption processes with the silicalite-1 zeolite to separate a mixture of difluoromethane (CH2F2, HFC-32) and pentafluoroethane (CF3CF2H, HFC-125) at various concentrations. Pure adsorption data were measured using a XEMIS gravimetric microbalance, whereas binary data were determined using the Integral Mass Balance method.

Ionic Liquids for the Separation of Fluorocarbon Refrigerant Mixtures.

This review discusses the research being performed on ionic liquids for the separation of fluorocarbon refrigerant mixtures. Fluorocarbon refrigerants, invented in 1928 by Thomas Midgley Jr., are a unique class of working fluids that are used in a variety of applications including refrigeration.

The Nuances Surrounding Insulin Prescribing.

Knowledge of and expertise in insulin prescribing is crucial for health care providers who care for people with diabetes. This article reviews the available insulin preparations, how they are packaged, and nuances related to storage and use that inform the prescribing of this life-saving medication for patients. Insulin prescribing that is done correctly will save time and reduce problematic errors that could put patients at risk.

Separation of Azeotropic Hydrofluorocarbon Refrigerant Mixtures: Thermodynamic and Kinetic Modeling for Binary Adsorption of HFC-32 and HFC-125 on Zeolite 5A.

Hydrofluorocarbons (HFCs) have been used extensively as refrigerants over the past four decades; however, HFCs are currently being phased out due to large global warming potentials. As the next generation of hydrofluoroolefin refrigerants are phased in, action must be taken to responsibly and sustainably deal with the HFCs currently in circulation. Ideally, unused HFCs can be reclaimed and recycled; however, many HFCs in circulation are azeotropic or near-azeotropic mixtures and must be separated before recycling.

Ibrexafungerp in the Treatment of Vulvovaginal Candidiasis.

Objective: To review the pharmacology, efficacy, and safety of ibrexafungerp in the management of vulvovaginal candidiasis (VVC).

Data Sources: Literature was sought using PubMed (1966-February 2022) and EMBASE (1973-February 2022), and clinicaltrials.gov.

Implementation of an EMS protocol to improve prehospital sepsis recognition.

Purpose: Optimal sepsis outcomes are achieved when sepsis is recognized early. Recognizing sepsis in the prehospital, EMS setting can be challenging and unreliable. The purpose of this study is to evaluate whether implementation of an EMS sepsis screening and prehospital alert protocol called PRESS (PREhospital SepsiS) is associated with improved sepsis recognition by EMS providers.

The association of indoor heat exposure with diabetes and respiratory 9-1-1 calls through emergency medical dispatch and services documentation.

Background: People with pre-existing medical conditions, who spend a large proportion of their time indoors, are at risk of emergent morbidities from elevated indoor heat exposures. In this study, indoor heat of structures wherein exposed people received Grady Emergency Services based care in Atlanta, GA, U.S.

Difluoromethane (HFC-32) and Pentafluoroethane (HFC-125) Sorption on Linde Type A (LTA) Zeolites for the Separation of Azeotropic Hydrofluorocarbon Refrigerant Mixtures.

Worldwide use of hydrofluorocarbons (HFCs) is currently being regulated and phased out because of high global warming potentials (GWPs). Separation techniques for recycling refrigerants are needed so that HFCs can be dealt with responsibly. Many HFCs currently in use are azeotropic or near-azeotropic refrigerant blends and must be separated so that the components can be recycled and repurposed effectively.

Limb Volume Changes and Activities of Daily Living: A Prospective Study.

Breast cancer-related lymphedema (BCRL) limits the movements of patients' limbs, which leads to a diminished ability to achieve essential activities of daily living (ADLs). The purpose of this study was to examine the associations between limb volume changes from the baseline before breast cancer surgery and self-reported difficulty in performing ADLs at 12 months following cancer surgery. We hypothesized that a positive association existed between limb volume changes from the baseline and self-reported difficulty in performing ADLs at 12 months following breast cancer surgery.

Impact of a Pharmacy-Driven Transitions of Care Medication Reconciliation Following Hospitalization.

Medication changes are common after hospitalizations, and medication reconciliations are one tool to help identify potential medication discrepancies. To determine the impact of a pharmacy-driven medication reconciliation service on number of medication discrepancies identified. This was a retrospective cohort, chart-review study conducted at an internal medicine outpatient clinic.

Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl.

Introduction: Illicitly manufactured fentanyl (IMF) is responsible for a growing number of deaths. Some case series have suggested that IMF overdoses require significantly higher naloxone doses than heroin overdoses. Our objective was to determine if the naloxone dose required to treat an opioid overdose is associated with the finding of fentanyl, opiates, or both on urine drug screen (UDS).

Pharmacists' Perspectives on Prescribing and Expanding Access to Hormonal Contraception in Pharmacies in the United States.

Introduction: Pharmacist prescribing of contraception is becoming increasingly available in selected states. The objective of this study was to assess US community pharmacists' perspectives on expanding access, barriers, and facilitators since states have begun pharmacist scope of practice expansions for prescribing contraception.

Methods: A survey study of US community pharmacists' support for expanded access models, pharmacist prescribing practices and interest, and importance of safety, cost, and professional practice issues for prescribing was conducted.

Evaluation of the impact of body mass index on warfarin requirements in hospitalized patients.

Background: Despite well established empiric dose adjustments for drug and disease-state interactions, the impact of body mass index (BM) on warfarin remains unclear. The objective of this study is to evaluate warfarin requirements in hospitalized patients, stratified by BMI.

Methods: This retrospective review included two cohorts of patients: cohort A (patients admitted with a therapeutic international normalized ratio (INR)) and cohort B (newly initiated on warfarin during hospitalization).

Smoking Cessation Following Text Message Intervention in Pregnant Women.

Background: Smoking during pregnancy has detrimental effects on mother and fetus. Text messaging has been utilized to improve patient care.

Objective: To evaluate the impact of text messaging on smoking cessation rates among pregnant women in addition to standard of care (SOC) smoking cessation services.

Accuracy of Prehospital Identification of Stroke in a Large Stroke Belt Municipality.

Objective: Strokes are a leading cause of morbidity and mortality in the United States, especially in the "stroke belt" of the southeast. Up to 65% of stroke patients access care by calling 9-1-1. The primary objective of this study is to measure the accuracy of emergency medical dispatchers (EMD) and paramedics, in the prehospital identification of stroke.

Guide for Drug Selection During Pregnancy and Lactation: What Pharmacists Need to Know for Current Practice.

Objective: To provide guidance for clinicians on risk assessment of medication use during pregnancy and lactation.

Data Sources: Authors completed PubMed searches to identify articles focused on the use of medications in pregnancy, including fetal development, drug transfer across the placenta, trimester exposure, chronic conditions in pregnancy, medications in lactation, and lactation and chronic disease.

Study Selection And Data Extraction: Articles were reviewed to provide overall guidance to medication selection during pregnancy.

Administration Rates of the Tdap Vaccine in Obstetric Patients.

Background: Infants younger than 6 months of age are at high risk for contracting pertussis because of not being fully vaccinated. The Advisory Committee on Immunization Practices (ACIP) recommends vaccinating all pregnant women with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) between 27 and 36 weeks to offer passive immunity to the infant to help protect them until they are able to receive the full pertussis series.

Objective: To assess and compare compliance with the 2013 ACIP recommendation of vaccinating pregnant women with Tdap at 27 to 36 weeks' gestation in 2 obstetric clinics.

Utilization of external reviews by colleges of pharmacy during the promotion and tenure process for pharmacy practice faculty.

Objective: To evaluate the use of external reviews by colleges of pharmacy (COP) during the promotion and tenure process for pharmacy practice faculty.

Methods: A 25-item web-based survey was sent to 112 Pharmacy Practice Department Chairs. Results were analyzed via descriptive statistics.

Emergency Medical Services Provider Experiences of Hospice Care.

Background: Growing numbers of emergency medical services (EMS) providers respond to patients who receive hospice care. The objective of this investigation was to assess the knowledge, attitudes, and experiences of EMS providers in the care of patients enrolled in hospice care.

Methods: We conducted a survey study of EMS providers regarding hospice care.

The FAST-ED App: A Smartphone Platform for the Field Triage of Patients With Stroke.

Background And Purpose: The Emergency Medical Services field triage to stroke centers has gained considerable complexity with the recent demonstration of clinical benefit of endovascular treatment for acute ischemic stroke. We sought to describe a new smartphone freeware application designed to assist Emergency Medical Services professionals with the field assessment and destination triage of patients with acute ischemic stroke.

Methods: Review of the application's platform and its development as well as the different variables, assessments, algorithms, and assumptions involved.

The State of Emergency Medical Services (EMS) Systems in Africa.

Unlabelled: Introduction Little is known about the existence, distribution, and characteristics of Emergency Medical Services (EMS) systems in Africa, or the corresponding epidemiology of prehospital illness and injury.

Methods: A survey was conducted between 2013 and 2014 by distributing a detailed EMS system questionnaire to experts in paper and electronic versions. The questionnaire ascertained EMS systems' jurisdiction, operations, finance, clinical care, resources, and regulatory environment.

Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy.

Objective: To evaluate maternal and neonatal safety outcomes for methadone and buprenorphine in the obstetric population.

Data Sources: A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy. The bibliographies were reviewed for other relevant articles.