Development and validation of an Immune-related Gene-based model for predicting prognosis and immunotherapy outcomes in hepatocellular carcinoma patients.

Predicting disease prognosis and the efficacy of immunotherapy presents a significant challenge in the treatment of hepatocellular carcinoma (HCC). By analyzing transcriptome sequencing data from 69 patients and identifying differentially expressed immune genes, a prognostic index named the immune-related gene prognostic index (IRGPI) was established by Lasso-Cox regression. The IRGPI, which consists of six key genes, was found to be a significant predictor of poor prognosis in patients with high IRGPI scores.