FMCW Laser Fuze Structure with Multi-Channel Beam Based on 3D Particle Collision Scattering Model under Smoke Interference.

In the environment of smoke and suspended particles, the accurate detection of targets is one of the difficulties for frequency-modulated continuous-wave (FMCW) laser fuzes to work properly in harsh conditions. To weaken and eliminate the significant influence caused by the interaction of different systems in the photon transmission process and the smoke particle environment, it is necessary to increase the amplitude of the target echo signal to improve the signal-to-noise ratio (SNR), which contributes to enhancing the detection performance of the laser fuze for the ground target in the smoke. Under these conditions, the particle transmission of photons in the smoke environment is studied from the perspective of three-dimentional (3D) collisions between photons and smoke particles, and the modeling and Unity3D simulation of FMCW laser echo signal based on 3D particle collision is conducted.

Active Ingredients and Mechanism of Gegen Qinlian Decoction in the Treatment of Diabetic Cardiomyopathy: A Network Pharmacology Study.

Background: Diabetic cardiomyopathy (DCM) is a common diabetes complication with limited medications. Gegen Qinlian decoction (GQD) has been used in the treatment of diabetes and its related complications in China for several decades.

Objective: In this study, network pharmacology was employed to predict the active ingredients, key targets, and pathways involved in the treatment of DCM by GQD and to validate it by animal experiments.

Modulated Radio Frequency Stealth Waveforms for Ultra-Wideband Radio Fuzes.

The increasingly complex electromagnetic environment of modern warfare and the proliferation of intelligent jamming threaten to reduce the survival rate of radio fuzes on the battlefield. Radio frequency (RF) stealth technology can fundamentally improve the anti-interception and reconnaissance capabilities of radio fuzes, thereby lessening the probability of them being intercepted, recognized, and jammed by the enemy. In this paper, an RF stealth waveform based on chaotic pulse-position modulation is proposed for ultra-wideband (UWB) radio fuzes.

Virtual Simulation of the Effect of FMCW Laser Fuse Detector's Component Performance Variability on Target Echo Characteristics under Smoke Interference.

The laser transmitter and photoelectric receiver are the core modules of the detector in a laser proximity fuse, whose performance variability can affect the accuracy of target detection and identification. In particular, there is no study on the effect of detector's component performance variability on frequency-modulated continuous-wave (FMCW) laser fuse under smoke interference. Therefore, based on the principles of particle dynamic collision, ray tracing, and laser detection, this paper builds a virtual simulation model of FMCW laser transmission with the professional particle system of Unity3D, and studies the effect of performance variability of laser fuse detector components on the target characteristics under smoke interference.

Boundary force exerted on spatial solitons in cylindrical strongly nonlocal media.

We investigate the propagation of spatial solitons in cylindrical strongly nonlocal media by a method of image beam of light. The dynamic force of the soliton steering resulting from the boundary effect is equivalent to the force between the soliton beam and the image beam. The trajectory of the soliton is analytically studied, which is in good agreement with the experimental results.

Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues.

Regulator of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) for Galpha subunits and negatively regulate G protein-coupled receptor signaling. Using RGS5 gene-specific RT-PCR, we have identified a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. The alternative splicing of RGS5 mRNA occurred at position +44 (GenBank NM_003617), spliced out 174 bp (+44 to +218 bp) of the coding region, and encoded an RGS5s protein with a 108 amino acid N-terminal deletion.

Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription.

1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 expression are dose- and time-dependent.

Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide.

Apolipoprotein E (apoE) and apoJ are lipid carriers produced in the brain primarily by glial cells. A variety of glial-activating stimuli induce a parallel upregulation of both apolipoproteins expression in vivo and in vitro. To further characterize the cell type and mechanisms by which apoE and apoJ expression are upregulated in activated glia, mixed glial cultures from neonatal rat cortex were treated with the endotoxin lipopolysaccharide (LPS).

Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression.

Connective tissue growth factor (CTGF) and Cyr61 (cysteine-rich angiogenic protein 61) are members of the CCN gene family that encode multifunctional, extracellular matrix-associated signaling proteins. Because the mechanism of action of certain anti-glaucoma drugs involves extracellular matrix remodeling of ocular ciliary muscle, with a resultant increase in drainage of aqueous humor from the eye, we compared the effects of three pharmacologically distinct ocular hypotensive agents on Cyr61 and CTGF gene expression. Thus, prostaglandin F2alpha (PGF2alpha) (FP receptor agonist), Butaprost (EP2 receptor agonist), and Bimatoprost (a prostamide) were compared.