Publications by authors named "Yanara Bernal"
Article Synopsis
- Cancers of unknown primary (CUP) are aggressive cancers where the origin remains unidentified, making treatment difficult and leading to poor outcomes.
- Advances in large-scale sequencing and machine learning have opened up new pathways for diagnosing CUP by identifying specific genetic signatures, even from blood samples.
- The review discusses the strengths and weaknesses of machine learning in classifying CUP tumors, emphasizing the need for improved strategies that integrate diverse data types to enhance diagnostic accuracy in clinical settings.
Background: The COVID-19 pandemic has shown the immediate risk for global and public health posed by vaccination inequities worldwide. The regions most affected are low- and middle-income countries (LMICs). In addition to systemic challenges, vaccine hesitancy driven by low vaccine confidence has been identified as a threat to vaccine uptake.
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- Tobacco use is a major risk factor for lung cancer, but 10-20% of lung cancer patients are never-smokers, with distinct clinical and genomic differences observed between smokers and never-smokers, especially in Chile.
- This study examines genomic alterations in lung cancer between smokers and never-smokers, focusing on 10 relevant genes, revealing a higher overall frequency of genetic alterations in never-smokers (58%) compared to smokers (45.7%).
- Key findings include that never-smokers tend to have higher alterations in genes like EGFR and PIK3CA, while smokers showcase a more complex genomic profile, particularly with KRAS mutations.
Epitranscriptomics is a field that delves into post-transcriptional changes. Among these modifications, the conversion of adenosine to inosine, traduced as guanosine (A>I(G)), is one of the known RNA-editing mechanisms, catalyzed by ADARs. This type of RNA editing is the most common type of editing in mammals and contributes to biological diversity.
View Article and Find Full Text PDFDysregulated A>I(G) RNA editing, which is mainly catalyzed by ADAR1 and is a type of post-transcriptional modification, has been linked to cancer. A low response to therapy in breast cancer (BC) is a significant contributor to mortality. However, it remains unclear if there is an association between A>I(G) RNA-edited sites and sensitivity to genotoxic drugs.
View Article and Find Full Text PDFChronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19.
Front Glob Womens Health
May 2022
Stress is known to be associated with adverse health outcomes. The COVID-19 pandemic and its associated lockdowns are examples of chronic stressors. Lockdown measures inadvertently caused significant psychological distress and became a powerful source of anxiety/stress, sleep disturbances, nutritional changes and weight gain.
View Article and Find Full Text PDFObjective: To evaluate the diagnostic performance of several biochemical predictors of insulin resistance (IR).
Design: A total of 90 nondiabetic subjects were tested with both the pancreatic suppression test (PST) and the oral glucose tolerance test (OGTT). Of them, 53 were non-insulin-resistant (NIR) subjects and the remaining 37 were insulin resistant subjects.