Publications by authors named "Yanan Song"

Silent new ipsilateral ischemic lesions (sNIIL) detected by diffusion-weighted imaging (DWI) are commonly observed after carotid artery stenting (CAS). We aimed to analyze the association of carotid plaque characteristics on Virtual Histology Intravascular Ultrasound (VH-IVUS) with sNIIL, which is not well understood. Among 128 patients who underwent CAS and VH-IVUS, 112 patients who underwent DWI within 72 h after CAS were included for analysis.

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Zinc (Zn) metal, with abundant resources, intrinsic safety, and environmental benignity, presents an attractive prospect as a novel electrode material. However, many substantial challenges remain in realizing the widespread application of aqueous Zn-ion batteries (AZIBs) technologies. These encompass significant material corrosion challenges (This can lead to battery failure in an unloaded state.

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Fruits and vegetables (F&Vs) are essential in daily life and industrial production. These perishable produces are vulnerable to various biotic and abiotic stresses during their growth, postharvest storage, and handling. As the fruit detaches from the plant, these stresses become more intense.

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Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosolic and nuclear proteins undergo O-GlcNAcylation, the possibility of FTO being O-GlcNAcylated and its functional implications remain unclear. This study found that a negative correlation between FTO expression and O-GlcNAcylation in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

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Introduction: Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and underlying mechanisms remain poorly understood. This study aims to uncover the molecular mechanisms through which ginsenoside Rh2 regulates apoptosis and proliferation in TNBC, offering new insights into its therapeutic potential.

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Hypoxic ischemic encephalopathy (HIE) is a brain injury that occurs in 1 ~ 5/1000 term neonates. Accurate identification and segmentation of HIE-related lesions in neonatal brain magnetic resonance images (MRIs) is the first step toward identifying high-risk patients, understanding neurological symptoms, evaluating treatment effects, and predicting outcomes. We release the first public dataset containing neonatal brain diffusion MRI and expert annotation of lesions from 133 patients diagnosed with HIE.

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Article Synopsis
  • Heparin is a complex polysaccharide used in medicine, and isolating it from biological mixtures like proteins is challenging, but this study introduces an eco-friendly method to create quaternized FeO@chitosan nanoparticles (QFCNs) for effective heparin adsorption.
  • The QFCNs achieved a high adsorption efficiency of 90.02% and showed better performance than existing adsorbents, indicating their potential for selective capture of heparin, especially in a mixture with BSA at neutral pH.
  • X-ray photoelectron spectroscopy suggested that the mechanism of adsorption involves electrostatic attraction between heparin and the quaternary ammonium groups on the QFCNs, making them a promising option for efficient and recyclable
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When creating a Schottky contact to suppress the leakage current of semiconductor γ-ray detectors and improve their energy resolution, it is successfully employed the fact that the formation of a Schottky barrier is determined not only by the difference in the electrode and semiconductor work functions but also affected by the semiconductor surface state. Oxygen plasma (OP) treatment has been used to modify the surface states of CdSe single crystals (SCs) prior to the Au electrode deposition, thereby creating a Schottky contact at the metal-semiconductor interface. The -type Schottky contact formation has been confirmed by the - characteristics and ultraviolet photoelectron spectroscopy analysis.

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  • * A patient with LUSC was found to have a new FGFR3-IER5L fusion through next generation sequencing and opted for anlotinib treatment instead of conventional therapies like surgery or chemotherapy.
  • * Anlotinib, a multi-target tyrosine kinase inhibitor, led to a partial response in the patient, resulting in a progression-free survival of 3.8 months.
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  • This study explored how the use of ECMO (extracorporeal membrane oxygenation) and IABP (intra-aortic balloon pump) affects in-hospital mortality for patients with STEMI (ST-segment elevation myocardial infarction) complicated by cardiogenic shock who are treated with primary PCI (percutaneous coronary intervention).
  • Data from 9,635 cases were analyzed, showing that patients on ECMO had a significantly lower in-hospital mortality rate (7.2%) compared to those on IABP (15.1%).
  • The results indicated a 34% reduced risk of in-hospital mortality for patients using ECMO when compared to IABP, suggesting ECMO offers a survival
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Purpose: System delay is associated with mortality in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). However, the influence of patient delay has been relatively overlooked. We aimed to evaluate the influence of patient and system delays on STEMI patients undergoing primary PCI in China.

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  • Acute lung injury (ALI) is a serious respiratory condition marked by inflammation and increased blood vessel permeability, with limited treatment options available.
  • The study focuses on understanding how Huangqin Qingfei Decoction (HQQFD), a Traditional Chinese Medicine known for its detoxifying effects, works to combat ALI and identifies key bioactive compounds contributing to its efficacy.
  • Utilizing advanced chemical analysis, researchers identified 105 compounds in HQQFD and established a network of 11 promising compounds that target important biological pathways associated with ALI, highlighting potential therapeutic agents for future treatments.
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Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer often associated with chronic hepatitis B virus infection (CHB) and liver cirrhosis (LC), underscoring the critical need for biomarker discovery to improve patient outcomes. Emerging as a promising avenue for biomarker development, proteomic technology leveraging liquid biopsy from small extracellular vesicles (sEV) offers new insights. Here, we evaluated various methods for sEV isolation and identified polysaccharide chitosan (CS) as an optimal approach.

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Resveratrol is a non-flavonoid polyphenolic compound with numerous functional properties, such as anticancer, anti-inflammation, anti-oxidation, anti-obesity and more. However, resveratrol's poor solubility within aqueous media and low stability usually lead to compromised bioavailability, ultimately limiting its uptake and applications. Nanodelivery technologies have been studied intensively due to their potential in effectively improving resveratrol properties, thereby providing promising solutions for enhancing the bioavailability of resveratrol.

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Amidst pressing global environmental challenges, exacerbated by climate change and the imminent threat of global warming, there is a critical need to assess the efficacy of environmental policies. This study centers its attention on the pivotal role of these policies in addressing environmental concerns. Specifically, our research aims to scrutinize the impact of stringent environmental policies on environmental quality under the theoretical underpinnings of environmental Kuznets curve.

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Neoadjuvant therapy (NAT) is an important treatment for patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC), but neoadjuvant resistance affects the overall treatment outcome. Therefore, it is particularly important to accurately screen the population for NAT and explore the mechanism of resistance. Usually, different chemotherapy regimens cause different drug resistance mechanisms.

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Background: Cisplatin (DDP) is a commonly used chemotherapy agent. However, its resistance to the drug is a major challenge in its clinical application. Earlier research has suggested a connection between HEATR1 and chemoresistance in cancer.

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Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the Transwell invasion assay data shown in Fig. 2C and D on p. 1997 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time (and in some cases, have subsequently been retracted).

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IFN regulatory factor 3 (IRF3) is the transcription factor crucial for the production of type I IFN in viral defence and inflammatory responses. The activity of IRF3 is strictly modulated by post-translational modifications (PTMs) to effectively protect the host from infection while avoiding excessive immunopathology. Here, we report that zebrafish myosin-regulated light chain interacting protein b (mylipb) inhibits virus-induced type I IFN production via two synergistic mechanisms: induction of autophagic degradation of irf3 and reduction of irf3 phosphorylation.

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The basic leucine zipper (bZIP) transcription factors (TFs) function importantly in numerous life processes in plants. However, bZIP members and their biological roles remain unknown in Camelina sativa, a worldwide promising oil crop. Here, 220 CsbZIP proteins were identified in camelina and classified into thirteen groups.

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Article Synopsis
  • Antimicrobial resistance presents a major health risk due to the serious infections caused by drug-resistant microbes, highlighting the need for effective identification methods.
  • This study introduces a sandwich-type electrochemical DNA biosensor using polyadenine-DNA tetrahedron probes, optimizing conditions for improved detection capabilities.
  • The biosensor demonstrated strong performance with a detection limit of 1 fM and successfully identified multiple drug resistance genes, showcasing its practical application for rapid detection of antibiotic-resistant strains.
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Delayed neurocognitive recovery (dNCR) is a common complication in geriatric surgical patients. The impact of anesthesia and surgery on patients with neurodegenerative diseases, such as Parkinson's disease (PD) or prion disease, has not yet been reported. In this study, we aimed to determine the association between a pre-existing A53T genetic background, which involves a PD-related point mutation, and the development of postoperative dNCR.

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Establish a new classification system of distal radius fracture based on computed tomographic (CT), and evaluate its reliability and reproducibility preliminarily, and provide a new theoretical reference for clinicians to use the clinical classification system. The imaging data and clinical data of 204 inpatients with distal radius fracture during 6 years from January 1, 2014 to January 1, 2019 in orthopaedic department were analyzed retrospectively and classified based on CT. Three observers evaluated the image data of 48 randomly selected cases based on CT at different time nodes of T1 and T2.

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Quantile regression, known as a robust alternative to linear regression, has been widely used in statistical modeling and inference. In this paper, we propose a penalized weighted convolution-type smoothed method for variable selection and robust parameter estimation of the quantile regression with high dimensional longitudinal data. The proposed method utilizes a twice-differentiable and smoothed loss function instead of the check function in quantile regression without penalty, and can select the important covariates consistently using the efficient gradient-based iterative algorithms when the dimension of covariates is larger than the sample size.

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The antibodies in the natural biological world utilize bivalency/multivalency to achieve a higher affinity for antigen capture. However, mimicking this mechanism on the electrochemical sensing interface and enhancing biological affinity through precise spatial arrangement of bivalent aptamer probes still pose a challenge. In this study, we have developed a novel self-assembly layer (SAM) incorporating triblock polyA DNA to enable accurate organization of the aptamer probes on the interface, constructing a "lock-and-key-like" proximity hybridization assay (PHA) biosensor.

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