Publications by authors named "Yanai Chen"

As a new type of transdermal drug delivery preparation, microneedles can improve the bioavailability of drugs and enhance patient compliance. This article develops a melatonin transdermal sustained-release microneedles using silk fibroin as the substrate. The silk fibroin in microneedles forms a SILK I crystal structure, which does not dissolve in the skin but has certain swelling properties.

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Bleeding and bacterial infection are common problems associated with wound treatment, while effective blood clotting and vessel regeneration promotion are the primary considerations to design the wound dressing materials. This research presents a chitosan-based hydrogel with grafted quaternary ammonium and polyphosphate (QCSP hydrogel) as the antibacterial hemostatic dressing to achieve burn wound treatment. The tissue adhesion of the hydrogel sealed the blood flow and the polyphosphate grafted to the chitosan promoted the activation of coagulation factor V to enhance the hemostasis.

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Article Synopsis
  • * Ursolic acid, derived from natural foods, has been shown to inhibit a specific lung cancer target, TMEM16A, with a significant effect on cancer cell growth and migration through certain cellular pathways.
  • * A new hydrogel drug-delivery system enhances the targeting of ursolic acid and cisplatin, leading to improved anti-tumor activity and reduced side effects in lung cancer treatment.
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Biodegradable self-healing hydrogels with antibacterial property attracted growing attentions in biomedication as wound dressings since they can prevent bacterial infection and promote wound healing process. In this research, a biodegradable self-healing hydrogel with ROS scavenging performance and enhanced tissue adhesion was fabricated from dopamine grafted oxidized pectin (OPD) and naphthoate hydrazide terminated PEO (PEO NH). At the same time, Fe ions were incorporated to endow the hydrogel with near-infrared (NIR) triggered photothermal property to obtain antibacterial activity.

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The incidence and mortality rates of lung cancer have remained high for several decades, necessitating the discovery of new drugs and the development of effective treatment strategies. This study identified matairesinoside (MTS) as a potent inhibitor of TMEM16A, a novel drug target for lung cancer. Molecular simulation combined with site-directed mutagenesis experiments confirmed the key binding sites of MTS and TMEM16A.

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Article Synopsis
  • Diabetic wounds are chronic, infection-prone injuries that are hard to heal due to high blood sugar levels.
  • Researchers developed a biodegradable hydrogel using a combination of dopamine-modified pectin and oxidized carboxymethyl cellulose to create a wound dressing with self-healing and anti-oxidation traits.
  • The hydrogel demonstrated quick formation, effective sealing for irregular wounds, and improved healing rates in diabetic mice models by delivering mEGF, showcasing its potential for wound healing applications.
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Serious side effects of chemotherapy drugs greatly limited the anticancer performance, while targeted drug delivery could improve the therapeutic effect and reduce side effects. In this work, biodegradable hydrogel was fabricated from pectin hydrazide (pec-H) and oxidized carboxymethyl cellulose (DCMC) for localized Silibinin delivery in lung adenocarcinoma treatment. The self-healing pec-H/DCMC hydrogel showed blood compatibility and cell compatibility both in vitro and in vivo, and could be degraded by enzymes.

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