Association between wide-ranging food intake and Parkinson's disease: a comprehensive mendelian randomization study.

Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by both genetic and environmental factors, including dietary habits. Despite considerable research, the relationship between food intake and PD risk remains poorly understood. Here, we conducted a comprehensive Mendelian randomization analysis to investigate the association between a wide spectrum of food intake and PD risk.

Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects.

Parkinson's disease (PD), a neurodegenerative disorder characterized by impaired motor function, is typically treated with medications and surgery. However, recent studies have validated physical exercise as an effective adjunct therapy, significantly improving both motor and non-motor symptoms in PD patients. Irisin, a myokine, has garnered increasing attention for its beneficial effects on the nervous system.

Emerging insights into Lipocalin-2: Unraveling its role in Parkinson's Disease.

Parkinson's disease (PD) ranks as the second most prevalent neurodegenerative disorder globally, marked by a complex pathogenesis. Lipocalin-2 (LCN2) emerges as a crucial factor during the progression of PD. Belonging to the lipocalin family, LCN2 is integral to several biological functions, including glial cell activation, iron homeostasis regulation, immune response, inflammatory reactions, and oxidative stress mitigation.

Effectiveness of the "Hand as Foot" teaching method in human physiology: A randomized controlled trial.

Background: The "Hand as Foot" teaching method, an innovative approach in medical education, utilizes hand gestures to simulate anatomical structures and functions. This study aimed to assess the effectiveness of the "Hand as Foot" teaching method compared to traditional method in the "Human Physiology" course.

Methods: During the 2023 spring semester, a randomized controlled trial involved 84 health management students.

Efficacy and safety of autologous platelet-rich plasma for diabetic foot ulcers: a systematic review and meta-analysis.

Objective: To investigate the efficacy and safety of autologous platelet-rich plasma (au-PRP) for diabetic foot ulcer (DFU) treatment.

Method: We conducted database searches (MEDLINE, EMBASE, evidence-based medicine reviews: CENTRAL, PubMed, and Web of Science) and reference mining for randomised controlled trials from inception to 23 January 2022. Results were scrutinised, data were extracted and research quality was investigated by two independent authors.

Impact of temperature changes between neighboring days on cardiovascular disease hospital admissions among suburban farmers in Qingyang, Northwest China.

Background: No studies focused on impact of temperature changes between neighboring days (TCN) on cardiovascular disease (CVD) hospital admissions among suburban farmers although CVD has been the main cause to global mortality and disability especially in undeveloped and developing countries/areas.

Method: Daily data of CVD hospital admissions on suburban farmers and daily data of meteorology in Qingyang (China) were collected during 2011-2015. A distributed lag non-linear model (DLNM) was applied to explore the exposure-response relations and lagged effects between TCN and CVD hospital admissions with stratified analyses by age and gender.

Association between ambient temperature and cardiovascular disease hospitalisations among farmers in suburban northwest China.

Cardiovascular disease (CVD) has become a severe public health and social issue in China. However, in northwest China, evidence on the association between ambient temperature and CVD hospitalisations in suburban farmers is somewhat limited. We collected CVD hospitalisations and meteorological data (2012-2015) in Zhangye suburbs and assessed the temperature-related risk and burden of admission by fitting a distributed lag nonlinear model to probe the relationship between ambient temperature and CVD hospitalisations among farmers in suburban northwest China.

Short-term effects of main air pollutants exposure on LOS and costs of CVD hospital admissions from 30,959 cases among suburban farmers in Pingliang, Northwest China.

Background: Although cardiovascular disease (CVD) has been the major contributor to global mortality and disability especially in undeveloped and developing countries/areas with severer air pollutions, studies are quite limited and evidence is insufficient of short-term main air pollutants exposure on health burden of CVD hospital admissions in those regions particularly through direct costs.

Method: Based on an analysis of 30,959 CVD hospital admissions among suburban farmers from 2018 to 2019 through multiple linear regression (MLR), our study evaluated the impact of main air pollutants (PM, PM, SO, CO, NO and O) exposure on number of cases, length of stay (LOS) and costs of CVD hospital admissions in Pingliang, China.

Results: Concentration of SO and O rising from a low level was found to lower the costs, LOS and daily cases of CVD hospital admissions and PM, PM, CO and NO were found to aggravate the burden.

Effects of diurnal temperature range on cardiovascular disease hospital admissions in farmers in China's Western suburbs.

Cardiovascular disease (CVD), reported to relate with climate change, is the leading cause of global mortality and morbidity. Since the relevant information is quite limited from suburbs and countryside in developing and underdeveloped countries, there are no studies that focused on morbidity through diurnal temperature range (DTR) for these regions. This is the first study to evaluate the short-term effect of DTR on CVD hospital admission in suburban farmers, as well as to identify vulnerable subpopulations.

Impact of ambient temperature on cardiovascular disease hospital admissions in farmers in China's Western suburbs.

Cardiovascular disease (CVD) has been a major threat to global public health. The association between temperature and CVD has been widely studied and reported in cities in developed countries. However, information from developing countries, especially from suburbs and countryside, is quite limited.

Progressive Encephalomyelitis With Rigidity and Myoclonus With Thymoma: A Case Report and Literature Review.

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is part of the variant type of the Stiff Person Syndrome (SPS) and is a rare neurological disease. We report here a patient with PERM who had thymoma and was positive for anti-glutamic acid decarboxylase (anti-GAD) antibodies. Her symptoms improved after treatment with hormones and gamma globulin.

Efficacy of interventions for amblyopia: a systematic review and network meta-analysis.

Background: Many treatments are currently available for amblyopic patients; although, the comparative efficacy of these therapies is unclear. We conducted a systematic review and network meta-analysis (NMA) to establish the relative efficacy of these treatments for amblyopia.

Methods: Electronic databases (MEDLINE, EMBASE, Cochrane Library) were systematically searched from inception to Sep.

Efficacy and safety of recombinant human epidermal growth factor for diabetic foot ulcers: A systematic review and meta-analysis of randomised controlled trials.

To evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in treating diabetic foot ulcers (DFUs), we conducted both database searches (PubMed, MEDLINE, EMBASE, CENTRAL, and Web of Science) and reference searches for randomised controlled trials from the inception of databases to 30 January 2020. Two reviewers independently scrutinised the trials, extracted data, and assessed the quality of trials. The primary outcome was the proportion of complete healing.

Human amniotic membrane allograft, a novel treatment for chronic diabetic foot ulcers: A systematic review and meta-analysis of randomised controlled trials.

To evaluate the efficacy and safety of human amniotic membrane (HAM) allograft in treating chronic diabetic foot ulcers (DFUs), a comprehensive search of randomised controlled trials in MEDLINE, EMBASE, PubMed, CENTRAL and Web of Science was conducted to December 7, 2019. Two reviewers independently screened the studies, extracted data, and evaluated the quality of studies. The primary outcome was the proportion of complete healing.

Lag effect of air temperature on the incidence of respiratory diseases in Lanzhou, China.

Previous studies have found that ambient temperature was associated with respiratory disease. However, little evidence is available in Lanzhou, a semi-arid region in northwest China, and respiratory disease is not well understood. This study evaluated the risk of outpatient visits for respiratory diseases associated with ambient temperatures from 2007 to 2016 in Lanzhou.

Efficacy and safety of anti-EGFR monoclonal antibodies combined with different chemotherapy regimens in patients with RAS wild-type metastatic colorectal cancer: A meta-analysis.

Objectives: To investigate the efficacy and safety of adding anti-epidermal growth factor receptor [EGFR] MoAbs to various chemotherapy regimens in patients with RAS wild-type metastasized colorectal cancer (RAS WT metastatic colorectal cancer [mCRC]) and to identify the optimal combination regimens.

Methods: We searched MEDLINE, EMBASE, and CENTRAL from the inception date to 20th May 2019. Randomized clinical trials investigating chemotherapy with or without anti-EGFR MoAbs in treatment of patients with RAS WT mCRC were included.

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson's Disease.

Parkinson's disease (PD), clinically characterized by motor and nonmotor symptoms, is a common progressive and multisystem neurodegenerative disorder, which is caused by both genetic and environmental risk factors. The main pathological features of PD are the loss of dopaminergic (DA) neurons and the accumulation of alpha-synuclein (-syn) in the residual DA neurons in the substantia nigra pars compacta (SNpc). In recent years, substantial progress has been made in discovering the genetic factors of PD.

Benefits of Vitamins in the Treatment of Parkinson's Disease.

Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia. Currently, the pathogenic mechanism of PD remains unclear. Numerous clinical studies as well as animal and cell experiments have found a certain relationship between the vitamin family and PD.

Comparison of air pollution in Shanghai and Lanzhou based on wavelet transform.

For a long-period comparative analysis of air pollution in coastal and inland cities, we analyzed the continuous Morlet wavelet transform on the time series of a 5274-day air pollution index in Shanghai and Lanzhou during 15 years and studied the multi-scale variation characteristic, main cycle, and impact factor of the air pollution time series. The analysis showed that (1) air pollution in the two cities was non-stationary and nonlinear, had multiple timescales, and exhibited the characteristics of high in winter and spring and low in summer and autumn. (2) The monthly variation in air pollution in Shanghai was not significant, whereas the seasonal variation of air pollution in Lanzhou was obvious.