Self-Cascade of ROS/Glucose-Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF-κB Pathway.

Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, high blood glucose levels, and recalcitrant bacterial infections. This microenvironment is accompanied by long-term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, a hybridized novel gold-palladium (AuPd) nanoshell of the injectable/injectable hydrogel system UiO/AuPd/BNN6/PEG@Gel (UAPsBP@Gel) is developed.

Protein aggregation behavior and structural characteristics in a lipoxygenase-linoleic acid-wheat gluten model system.

This study explores the synergistic effects of linoleic acid (LA) oxidation on the aggregation behavior and structural properties of wheat gluten (WG). Using lipoxygenase to induce LA oxidation, it was observed that this process significantly influenced WG's viscoelasticity and structural characteristics. Specifically, LA oxidation enhanced WG's viscoelastic properties while reducing its instantaneous elastic and recovery deformations.

Physiological change in ganglion cell inner plexiform layer and nerve fibre layer thickness over six years.

Background: To evaluate the 6-year physiological rates-of-change in ganglion cell inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) thickness measured with optical coherence tomography.

Methods: We included 2202 out of 2661 subjects from the population-based Singapore Chinese Eye Study who returned for follow-up 6 years after baseline examination (follow-up rate 87.7%).

Relationship Between Early-Life Factors and Self-Reported Age at Myopia Onset: A Study Based on a Sample of Chinese Adults.

Aim: To investigate the influence of early-life factors (Season of birth, premature birth and breastfeeding) on the age at myopia onset.

Methods: A total of 331 myopic students aged 18 years or above were recruited from one medical university in Wenzhou, China. Questionnaires were administered to collect data on age at myopia onset, early-life factors, and vision hygiene habits.

Optimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice.

Spatial stable isotope tracing metabolic imaging is a cutting-edge technique designed to investigate tissue-specific metabolic functions and heterogeneity. Traditional matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) techniques often struggle with low coverage of low-molecular-weight (LMW) metabolites, which are often crucial for spatial metabolic studies. To address this, we developed a high-coverage spatial isotope tracing metabolic method that incorporates optimized matrix selection, sample preparation protocols, and enhanced post-ionization (MALDI2) techniques.

Experiences of burden and needs in caregivers with pediatric noninfectious uveitis: a qualitative study.

Background: Long-term, potentially lifelong therapy is needed to treat noninfectious uveitis (NIU) in children. Previous research has focused primarily on treatment approaches, but few studies have investigated the effect of children's chronic illness on other family members. The aim of this study is to explore the experiences of burden and needs in caregivers of children with NIU, and to provide a reference for formulating targeted intervention strategies.

Deficiency of EXT1 and FGFR3 genes promotes chondrocyte differentiation, leading to the induction of osteochondroma formation.

Objective: This study aims to investigate the roles of the EXT1 and FGFR3 genes in the development of osteochondromas, focusing specifically on their potential interactions in chondrocyte proliferation, differentiation, and tumor formation.

Methods: In vitro, the ATDC5 chondroprogenitor cell line was used to examine the effects of inactivation of both EXT1 and FGFR3. In vivo, a mouse model with dual gene knockout of Ext1 and Fgfr3 was constructed to further explore these genes' roles in tumor formation by observing the incidence and distribution patterns of osteochondromas.

Stretchable Multimodal Photonic Sensor for Wearable Multiparameter Health Monitoring.

Stretchable sensors that can conformally interface with the skins for wearable and real-time monitoring of skin deformations, temperature, and sweat biomarkers offer critical insights for early disease prediction and diagnosis. Integration of multiple modalities in a single stretchable sensor to simultaneously detect these stimuli would provide a more comprehensive understanding of human physiology, which, however, has yet to be achieved. Here, this work reports, for the first time, a stretchable multimodal photonic sensor capable of simultaneously detecting and discriminating strain deformations, temperature, and sweat pH.

Lipidomics and spatial metabolomics reveal the heterogeneity in lipid distribution within pecan kernels.

Pecan (Carya illinoinensis) is a globally important nut crop, yet the processes of lipid biosynthesis and spatial lipid distribution within its embryo remain poorly understood. This study employed UHPLC-MS/MS and MALDI-MSI to profile lipids in developing pecan embryos, identifying 401 lipid molecules, including a high abundance of glycerolipids (148) and glycerophospholipids (144). Differential diacylglycerols showed gradual uptrends, highlighting their role in synthesizing glycerolipids and glycerophospholipids.

Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.

Background: Obstructed defecation syndrome (ODS) represents the most prevalent form of chronic constipation, affecting a diverse patient population, leading to numerous complications, and imposing a significant burden on healthcare resources. Most ODS patients have insufficient rectal propulsion, but the exact mechanism underlying the pathogenesis of ODS remains unclear.

Aim: To explore the molecular mechanism underlying the pathogenesis of ODS.

Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration.

The photosensitive S-nitrosocysteine (CysNO) could respond to light irradiation to produce nitric oxide (NO), exhibiting tremendous potential in accelerating peripheral nerve regeneration. However, its further application was limited by the burst release of NO and the requirement for ultraviolet excitation with low tissue penetration. Herein, a near-infrared-triggered NO controlled release nanosystem UCNP@ZIF-8/CysNO consisting of an upconversion nanoparticle (UCNP) core and zeolitic imidazolate framework-8 (ZIF-8) shell loading with CysNO was constructed, and then blended with poly-l-lactic acid powder to fabricate nerve scaffold by laser additive manufacturing technique.

Antagonistic Effect of Nitrate Conversion on Photocatalytic Reduction of Aqueous Pertechnetate and Perrhenate.

Sustainable photocatalysis can effectively reduce the radioactive TcO to less soluble TcO·HO(s), but the reduction efficiency is highly susceptible to coexisting nitrate (NO). Here, we quantitatively investigate photocatalytic remediation conditions for Tc-contaminated water stimulated by the analogue perrhenate (ReO) in the presence of NO, and we elucidate the influence mechanism of NO by in situ characterizations. The interfering NO can compete with Re(VII) for the carbonyl radical (·CO) produced by formic acid (HCOOH) oxidation to generate nitrogen-containing products such as NH, NO, and NO, resulting in the decrease in the Re(VII) reduction ratio.

Current status and hotspots in breast cancer patient self-management research: A bibliometric and visual analysis via CiteSpace.

Background: Breast cancer remains a leading cause of cancer-related mortality worldwide. Patient self-management plays a pivotal role in enhancing outcomes and quality of life for individuals affected by this disease. This study employed bibliometric and visual analysis techniques utilizing CiteSpace to elucidate the current status and research hotspots in breast cancer patient self-management from January 1, 2005, to August 31, 2023.

Solvent-free ball milling activation of cellulose for efficient surface modification and pyrolysis.

Due to the innate recalcitrancy caused by robust hydrogen bonding interaction, cellulose cannot be easily processed into high-valued materials or chemicals. Herein, a solvent-free ball milling treatment was conducted to activate microcrystalline cellulose (MCC). The research results demonstrated that ball milling treatment rapidly reduced the average particle size (Ð) and crystalline index (CrI) of MCC.

Knowledge, attitude and practice of pediatric healthcare staff towards the therapy for patients with congenital heart disease.

Background: This study aimed to investigate the knowledge, attitude and practice (KAP) of pediatric healthcare staff towards the therapy for patients with congenital heart disease (CHD). CHD is a major global health concern, posing significant risks to health and life despite advancements in early detection and treatment.

Methods: This web-based cross-sectional study was conducted from May 04, 2023 to August 12, 2023 in the Bengbu area (three counties and one city) for pediatric healthcare staff.

Transcriptomic analysis reveals decreased expression of detoxification genes in Caenorhabditis elegans exposed to mepanipyrim and cyprodinil: Implications for multigenerational exposure effects.

The broad-spectrum fungicides mepanipyrim (Mep) and cyprodinil (Cyp) have been reported to be used worldwide to control gray mold of fruit crops. Consequently, they are often detected in the water and food items. However, the impacts and potential mechanisms of these two pesticides on environmental organisms remain unclear.

Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications.

Zero-dimensional (0D) halide perovskites have garnered significant interest due to their novel properties in optoelectronic and energy applications. However, the mechanisms underlying their phase transformations and fluorescence properties remain poorly understood. In this study, we have synthesized a micron-scale 0D perovskite observable under confocal laser scanning microscopy (CLSM).

A novel method to predict white blood cells after kidney transplantation based on machine learning.

Background: Abnormal white blood cell count after kidney transplantation is an important adverse clinical outcome. The abnormal white blood cell count in patients after surgery may be caused by the use of immunosuppressive agents and other factors. A lower white blood cell count than normal will greatly increase the probability of adverse outcomes such as infection and reduce the success rate of surgery.

The Hidden Mechanism: Excited-State Proton-Electron Pair Transfer in Metal Nanocluster Emission.

Comprehending the underlying factors that govern photoluminescence (PL) in metal nanoclusters (NCs) under physiological conditions remains a highly intriguing and unresolved challenge, particularly for their biomedical applications. In this study, we evaluate the critical role of excited-state proton-coupled electron transfer in the emission of metal NCs. Our findings demonstrate that hydronium ion (HO) binding can trigger a nonlinear, pH-dependent excited-state concerted electron proton transfer (CEPT) reaction.

Insights into the enhancement mechanism of rheological properties of dough induced by wheat flour maturation: The view from gluten proteins aggregation.

To elucidate the mechanisms underlying the changes in the rheological properties of dough made from wheat flour during maturation, the molecular structure of gluten before and after maturation was characterized. Wheat flour was matured under three distinct conditions for predetermined durations. The development time, stability, and maximum force of dough peaked at 7.