Gadoxetic acid disodium (Gd-EOB-DTPA) contrast-enhanced abbreviated magnetic resonance imaging (MRI) for hepatocellular carcinoma surveillance in at-risk patients: a multi-center study in China.

Background: Given the limited capacity and suboptimal sensitivity of ultrasonography (US), gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) demonstrates good diagnostic performance for hepatocellular carcinoma (HCC). Some researchers have proposed that the abbreviated MRI (AMRI) protocols have potential as a surveillance tool. However, few studies have compared multiple AMRI protocols with complete Gd-EOB-DTPA contrast-enhanced MRI for HCC surveillance.

Microbiological, physicochemical, textural, and rheological properties of fermented soymilk produced with Enterococcus faecium and Lactiplantibacillus plantarum.

The selection of appropriate starter cultures is a crucial factor in determining the quality of fermented soymilk products. This study evaluated the effects of a combined starter culture of Enterococcus faecium CGMCC 29309 and Lactiplantibacillus plantarum CGMCC 29306 on the microbiological, physicochemical, textural and rheological characteristics of fermented soymilk. The results indicated that the mixed-strain fermentation significantly increased the concentrations of free isoflavones, free amino acids, free fatty acids, and aroma compound acetaldehyde, 2,3-butanedione and acetoin, and significantly reduced the level of beany compound hexanal.

Effects of the Interaction Between Time-on-Task and Task Load on Response Lapses.

To investigate the interaction effects of prolonged working periods and different task loads on response lapses, focusing on the mechanisms of delayed responses and error lapses. Professionals such as pilots, truck drivers, and nurses often face extended work hours and fluctuating task loads. While these factors individually affect performance, their interaction and its impact on response lapses remain unclear.

Dispersion response broadband tunable underwater FMCW blue chirped laser source.

Frequency-modulated continuous-wave (FMCW) narrow linewidth lasers have served as the cornerstone behind applications such as autonomous driving, wearable technology, virtual reality, and remote sensing mapping. Strongly coherent lasers are typically used for these studies, with a clear demand for linear fast response and wide frequency tuning range. In this paper, profiting from the ultrahigh-quality factor of the crystalline whispering-gallery-mode resonator, by using a self-injection locking mechanism to suppress spontaneous emission noise and improve coherence, sub-kHz linewidth at 450 nm is obtained.

Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K/AKT pathway and targeting EGFR/ALB in rats.

Ethnopharmacological Relevance: Abnormal endocrine metabolism caused by polycystic ovary syndrome (PCOS) poses a serious risk to reproductive health in females. According to Traditional Chinese Medicine (TCM) theories, the leading causes of PCOS include turbid phlegm, blood stasis and stagnation of liver Qi. Rhei Radix Et Rhizome is widely used in TCM to attack stagnation, clear damp heat, relieve fire.

Arsenic release during groundwater recharge and effects of coexisting ions in a typical inland basin with high arsenic concentration: Modeling and batch experiment.

Groundwater recharge is a viable solution to groundwater overexploitation. However, the injection of recharge water may break the dissolution balance and induce the release of trace elements especially arsenic (As), which has been identified in river deltas. Only a few studies have been conducted in inland basins with high As concentration, high pH, and low Eh.

In vivo determination of the bioavailability of folic acid through the utilization of the PBPK model in conjunction with UPLC.

This paper employed a physiologically based pharmacokinetic model (PBPK) to investigate the transformations of folic acid and its metabolites in vivo. Additionally, an ultra-performance liquid chromatography (UPLC) method was developed to accurately measure the body's retention rate and conversion rate of folic acid, tetrahydrofolate, and 5-methyltetrahydrofolate. Furthermore, the bioavailability of folic acid in the body was assessed by combining this method with an evaluation technique for animal models.

Accelerated and precise identification of antioxidants and pesticides using a smartphone-based colorimetric sensor array.

The integration of smartphones with conventional analytical approaches plays a crucial role in enhancing on-site detection platforms for point-of-care testing. Here, we developed a simple, rapid, and efficient three-channel colorimetric sensor array, leveraging the peroxidase (POD)-like activity of polydopamine-decorated FeNi foam (PDFeNi foam), to identify antioxidants using both microplate readers and smartphones for signal readouts. The exceptional catalytic capacity of PDFeNi foam enabled the quick catalytic oxidation of three typical peroxidase substrates (TMB, OPD and 4-AT) within 3 min.

High resolution acoustic sensing based on microcavity optomechanical oscillator.

In this paper, a simple sensing method based on a silicon oxide microcavity optomechanical oscillator (OMO) is proposed and demonstrated for the detection of acoustic signals. Firstly, the resonance damping was reduced by improving the optical quality factor (Q) and increasing the sphere-to-neck ratio. After optimizing the process, a microsphere OMO was fabricated, which has an ultra-high mechanical quality factor (6.

Insight into the Mechanism Underlying the Reduction of Digestibility and IgG/IgE Binding Ability in Ovalbumin during Different High-Temperature Conduction Modes-Induced Glycation.

Effects of different high-temperature conduction modes [high-temperature air conduction (HAC), high-temperature contact conduction (HCC), high-temperature steam conduction (HSC)]-induced glycation on the digestibility and IgG/IgE-binding ability of ovalbumin (OVA) were studied and the mechanisms were investigated. The conformation in OVA-HSC showed minimal structural changes based on circular dichroism, fluorescence, and ultraviolet spectroscopy. The degree of hydrolysis analysis indicated that glycated OVA was more resistant to digestive enzymes.

Ultra-stable control near the EP in non-Hermitian systems and high-precision angular rate sensing applications.

In non-Hermitian systems, enhancing sensitivity under exceptional point (EP) conditions offers an ideal solution for reconciling the trade-off between sensitivity and size constraints in sensing applications. However, practical application is limited by undesired sensitivity to external fluctuations, noise, and errors in signal amplification synchronization. This paper presents a precisely controlled EP tracking and detection system (EPTDS) that achieves long-term rapid tracking and locking near the EP by constructing a second-order non-Hermitian optical sensing unit, employing an optical power adaptive control method, and utilizing a combinatorial demodulation-based dual-loop cascaded control (CDCC) technique to selectively suppress traditional noise at different frequencies.

Bridging techniques compared with direct endovascular therapy for stroke due to tandem occlusion: A systematic review and meta-analysis.

The superiority of the bridging strategy of intravenous thrombolysis (IVT) plus endovascular therapy (EVT) to EVT alone for the anterior circulation with tandem vascular occlusion (TO) has not been specifically addressed by a single randomized trial. Analysis of 15 studies (n = 1857 patients) revealed that 90 Day good functional outcomes (MRS≤2) were better for bridging therapy (IVT + EVT) than for dEVT (OR:1.39, 95%CI: 1.

Differentiating mass-forming intrahepatic cholangiocarcinoma from atypical hepatocellular carcinoma using Gd-EOB-DTPA-enhanced magnetic resonance imaging combined with serum markers in at-risk patients with hepatitis B virus.

Background: The precise differentiation of intrahepatic cholangiocarcinoma (ICC) from atypical hepatocellular carcinoma (HCC) is vital for treatment strategy and prognostic prediction. In clinical practice, nearly 40% of HCCs demonstrate atypical manifestations, particularly HCCs with rim arterial phase hyperenhancement (APHE), which is challenging to differentiate from mass-forming ICC. Thus, we aimed to develop a diagnostic regimen of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) contrast-enhanced magnetic resonance imaging (MRI) combined with serum tumor markers in differentiating mass-forming ICC from atypical HCC in at-risk patients with the hepatitis B virus (HBV).

Effects of different high-temperature conduction modes on the ovalbumin-glucose model: AGEs production and regulation of glycated ovalbumin on gut microbiota.

Food high-temperature processing frequently induces the production of advanced glycation end products (AGEs) in the food industry. In this study, the effects of three high-temperature conduction modes on the AGEs production derived from ovalbumin (OVA)-glucose model and the regulation of glycated OVA on gut microbiota were investigated. The peak time of OVA shifted maximally from 13.

The sustained attention characteristics of flight crews on exempt and non-exempt flights.

We analyzed the characteristics of sustained attention changes in flight crews during exempt and non-exempt flights. Fourteen pilots (aged 30-43 y) participated in this study, with seven involved in each flight type, all of which were intercontinental (China to North America). Pilots completed continuous performance tests (CPT) at the required flight stages without compromising safety while on duty.

Evaluation of the Inhibition Potency of Nirmatrelvir against Main Protease Mutants of SARS-CoV-2 Variants.

SARS-CoV-2 continues to pose a threat to public health. Main protease (M) is one of the most lucrative drug targets for developing specific antivirals against SARS-CoV-2 infection. By targeting M, peptidomimetic nirmatrelvir is able to inhibit viral replication of SARS-CoV-2 and reduce the risk for progression to severe COVID-19.

An ultrahigh sensitivity acoustic sensor system for weak signal detection based on an ultrahigh- CaF resonator.

Acoustic sensors with ultrahigh sensitivity, broadband response, and high resolution are essential for high-precision nondestructive weak signal detection technology. In this paper, based on the size effect of an ultrahigh-quality () calcium fluoride (CaF) resonator, a weak acoustic signal is detected by the dispersive response regime in which an acoustic, elastic wave modulates the geometry and is converted to a resonance frequency shift. Through the structural design of the resonator, the sensitivity reaches 11.

Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.

PF-07321332 and PF-07304814, inhibitors against SARS-CoV-2 developed by Pfizer, exhibit broad-spectrum inhibitory activity against the main protease (M) from various coronaviruses. Structures of PF-07321332 or PF-07304814 in complex with Ms of various coronaviruses reveal their inhibitory mechanisms against different Ms. However, the structural information on the lower pathogenic coronavirus M with PF-07321332 or PF-07304814 is currently scarce, which hinders our comprehensive understanding of the inhibitory mechanisms of these two inhibitors.

Sandwich structure magnetometer with a high sensitivity and signal-to-noise ratio based on an ultrahigh-Q CaF resonator.

Whispering gallery mode (WGM) resonators with an ultrahigh quality () factor provide an extremely high resolution for high-precision sensing. However, it is difficult to use them directly in magnetic sensors because of the transparency to the magnetic field. In this paper, a sandwich structure consisting of a neodymium iron boron magnet and calcium fluoride resonator with a factor of 10 is proposed.

Design of an ultra-broadband and low-loss 3 dB power splitter from the 1.25 to 2.04 µm wave band.

As a key component of the beam splitting and combining in photonic integrated circuits, an optical power splitter requires the characteristics of compactness, broadband, and low loss. Here, we propose a 1×2 ultra-broadband 3 dB power splitter with a 5 µm long beam splitting area, based on the structure of a subwavelength grating. The 0.

Effects of total sleep deprivation on execution lapses during vigilance tasks.

Total sleep deprivation (TSD) results in reduced efficiency of cognitive resources. Moreover, when the available cognitive resources are less than required, individuals exhibit lapses in responsiveness. Accordingly, this study explored the effects of TSD on executive function and the characteristics of execution lapses.

Fatigue during Long-Haul Flights of Different Crew Compositions under Exemption from Layover and Flight Time during COVID-19.

Pilot fatigue and alertness are critical for civil aviation safety. Intercontinental pilots are more prone to fatigue and sleepiness due to jet lag, prolonged workdays, and disrupted rhythms. The Civil Aviation Administration of China excused enlarged flight crews from mandatory layovers and reimposed flight duration restrictions during COVID-19.

Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss.

Objectives: Changes in coagulation indexes, thromboelastogram(TEG) and autoantibodies in patients with recurrent pregnancy loss (RPL) with different number of abortions were analyzed.

Methods: Medical records of 48 patients with recurrent abortion, treated in Quzhou people's Hospital from November 2019 to October 2020, were collected as the observation group. Based on the number of abortions, patients were divided into Group-A (Two abortions, n=21), Group-B (Three abortions, n=16) and group C (Abortion ≥ four times, n=11).

Oxygen vacancies and interfacial iron sites in hierarchical BiOCl nanosheet microflowers cooperatively promoting photo-Fenton.

Controllable active site construction, crystal structure regulation and efficient charge separation are core issues in heterogeneous photo-Fenton. Herein, abundant oxygen vacancies and well-dispersed interfacial iron sites are simultaneously constructed in hierarchical nanosheet-assembled BiOCl microflowers. The composites exhibit superior performance in photo-Fenton oxidation of carbamazepine (10 mg L) with a low HO concentration (1.