Publications by authors named "YanRu Li"

Solid-state nanopore is a promising single molecular detection technique, but is largely limited by relatively low resolution to small-size targets and laborious design of signaling probes. Here we establish a universal, CRISPR/Cas-Assisted Nanopore Operational Nexus (CANON), which can accurately transduce different targeting sources/species into different DNA structural probes via a "Signal-ON" mode. Target recognition activates the cleavage activity of a Cas12a/crRNA system and then completely digest the blocker of an initiator.

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Functional redundancy is considered a pivotal mechanism for maintaining the adaptability of species by preventing the loss of key functions in response to dehydration. However, we still lack a comprehensive understanding of the redundancy of leaf hydraulic systems along aridity gradients. Here, photosynthesis (A), stomatal conductance (g) and leaf hydraulic conductance (K) during dehydration were measured in 20 woody species from a range of aridity index (AI) conditions and growing in a common garden to quantify stomatal redundancy (SR), the extent of stomatal opening beyond the optimum required for maximum photosynthesis (A), leaf hydraulic redundancy (HR), and the extent of leaf hydraulic conductance (K) beyond the optimum required for maximum g (g).

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Introduction: Antimicrobial peptides (AMPs) present a promising avenue to combat the growing threat of antibiotic resistance. The ruminant gastrointestinal microbiome serves as a unique ecosystem that offers untapped potential for AMP discovery.

Objectives: The aims of this study are to develop an effective methodology for the identification of novel AMPs from ruminant gastrointestinal microbiomes, followed by evaluating their antimicrobial efficacy and elucidating the mechanisms underlying their activity.

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The variability of the apnea-hypopnea index(AHI) measured in the first and second halves of the night is significant in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). This variation may be related to fluid redistribution caused by the supine position during sleep. Eighty-nine adult subjects were enrolled.

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Study Objectives: Obstructive sleep apnea (OSA) is a common disorder in the pediatric population, primarily diagnosed through polysomnography (PSG). However, PSG can be expensive and is often limited in availability. This study aimed to develop a cost-effective diagnostic strategy by integrating a screening model with PSG.

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Organic photodiodes (OPDs) that utilize wavelength-selective absorbing molecules offer a direct approach to capturing specific wavelengths of light in multispectral sensors/imaging systems without filters. However, they exhibit broad response bandwidths, low external quantum efficiency (EQE), and often require compromises in two-component photoactive materials. Herein, the first utility of boron-nitrogen (BN) single-component photoabsorbers, leveraging a multi-resonance effect are introduced to attain OPDs with both record-high EQE of 33.

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The U.S. Food and Drug Administration (FDA) recently approved lecanemab and donanemab for the treatment of early symptomatic Alzheimer's disease (AD) after their phase III trials reached endpoints.

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Staggered gap p-n heterojunction ZnO nanorods/AgO nanoparticles, a paradigm of photocatalysts, were developed via engineering the hydrothermal and coprecipitation method. Under simulated sunlight, the photocatalytic characteristics of ZnO/AgO(Zn/A) heterojunctions with varying mole ratios (from 8:1 to 8:4, named Zn/A-1-Zn/A-4) were systematically evaluated through the degradation of methylene blue (MB). The influence of key experimental variables, including photocatalyst concentration, MB concentration, and solution pH, on the photocatalyst performance was further analyzed.

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The rapid evolution of multifunctional wearable smart devices has significantly expanded their applications in human-computer interaction and motion health monitoring. Central to these devices are flexible sensors, which require high stretchability, durability, self-adhesion, and sensitivity. Biomacromolecules have attracted attention in sensor design for their biocompatibility, biodegradability, and unique mechanical properties.

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Introduction: Artificial intelligence is already widely utilized in gastroenterology. This study aims to comprehensively evaluate the research hotspots and development trends within the field of AI in gastroenterology by employing bibliometric techniques to scrutinize geographical distribution, authorship, affiliated institutions, keyword usage, references, and other pertinent data contained within relevant publications.

Methods: This investigation compiled all pertinent publications related to artificial intelligence in the context of gastrointestinal polyps and digestive endoscopy from 2003 to 2023 within the Web of Science Core Collection database.

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Sustained or chronic inflammation in the placenta can result in placental insufficiency, leading to adverse reproductive outcomes such as pregnancy loss. Branched-chain amino acid transaminase 1 (BCAT1) expresses in the placenta and is involved in the pathological inflammatory response, but its role in recurrent miscarriage (RM) has not been fully investigated. In the present study, we delved into the effects of BCAT1 on trophoblast inflammation induced by lipopolysaccharide (LPS) and a mouse model of pregnancy loss induced by LPS.

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  • The study focuses on identifying different stress types in maize leaves (like heavy metal, water, and fertilizer stress) using spectral data collected under various conditions.
  • Various preprocessing techniques and feature selection methods helped identify key spectral features that distinguish these stress types.
  • Classification models, particularly Random Forest and AdaBoost, showed high accuracy in classifying stress types, suggesting these methods could enhance maize stress monitoring in agriculture.
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  • Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury (DILI), with notable differences in how men and women are affected, pointing to potential links with gut microbiota.
  • Research indicates that higher levels of a gut microbiota compound called deguelin are present in women and female mice, which may help protect against liver damage from APAP.
  • Deguelin appears to reduce liver oxidative stress in male mice by inhibiting the expression of the thyrotropin receptor in liver cells, suggesting it could be a promising target for new DILI treatments based on gut microbiota.
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Background: The implications of pulmonary vein (PV) flow patterns in patients with heart failure (HF) and mitral regurgitation (MR) are uncertain. We examined PV flow patterns in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) trial (NCT01626079), in which patients with HF and moderate-to-severe or severe functional MR were randomized to transcatheter edge-to-edge repair (TEER) with the MitraClip device plus guideline-directed medical therapy (GDMT) vs. GDMT alone.

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  • - The study aimed to compare the effectiveness of the GI-RADS and ADNEX diagnostic models for identifying benign and malignant ovarian tumors by junior physicians, analyzing data from 634 patients over 4 years.
  • - Results showed that both models had high sensitivity and specificity, with GI-RADS slightly outperforming ADNEX in overall diagnostic accuracy but ADNEX proving more effective in distinguishing between benign tumors and advanced-stage cancers.
  • - The findings indicate that both models are highly reliable for diagnosing ovarian tumors, with ADNEX offering additional benefits for differentiating tumor types, supporting the skill level of junior doctors.
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  • - The study investigates how nitric oxide (NO) enhances polysaccharide production in Nostoc flagelliforme through a process called S-nitrosylation (SNO), which modifies certain enzymes involved in this biosynthesis.
  • - It was found that certain key enzymes (G6PDH, ICDH, and UGDH) have their activity correlated with NO levels, and specific enzymes (UGDH and G6PDH) are particularly affected by SNO, as shown through various laboratory techniques.
  • - The research identifies specific sites on the enzymes that are modified by NO and proposes that this mechanism could lead to improved industrial production of polysaccharides from Nostoc flagelliforme.
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  • Obstructive sleep apnea (OSA) is linked to sleep and psychological disorders, and the study investigates how brain asymmetry (BA) relates to these conditions in OSA patients.
  • The research involved 152 OSA and 21 non-OSA subjects, measuring brain activity during rest and sleep, and assessing psychological traits and clinical characteristics.
  • Findings indicate that OSA is associated with increased brain asymmetry, particularly in the right hemisphere, which correlates with traits like anxiety and extraversion, suggesting that sleep disturbances can affect psychological well-being.
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Anchoring Pt onto multi-heteroatom doped carbon materials has been recognized as an effective approach to improve the performance of electrocatalytic methanol oxidation. However, distinct contributions and specific behavior mechanisms of different heteroatoms, notably N and P, the specific behavior mechanisms in synergistically promoting Pt NPs remain elusive. In this work, we construct 1D N and P co-doped carbon nanotube (N, P-CNTs) supports with abundant defect anchors for Pt.

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Background: Transcatheter edge-to-edge repair (TEER) improved outcomes in patients with heart failure (HF) and severe secondary mitral regurgitation (SMR) compared with guideline-directed medical therapy (GDMT) alone regardless of the severity of baseline left ventricular ejection fraction (LVEF). The study aimed to evaluate the effect of early changes in LVEF after TEER and GDMT alone in patients with HF and severe SMR.

Methods: Within the COAPT trial, we evaluated outcomes according to changes in LVEF from baseline to 30 days.

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  • The study aimed to assess the effectiveness of combining the Hospital-Community-Home (HCH) model with the Self-Mutual-Group (SMG) health management model for improving the health of high-risk cardiovascular patients in Shijiazhuang.
  • A quasi-experimental design was used, wherein high-risk patients were randomly selected from two communities, and data on health behaviors and outcomes were collected and compared before and after the intervention.
  • Results showed that participants in the SMG group saw significant improvements, with decreased smoking and alcohol consumption rates, as well as an increase in those engaging in leisure exercises, while the control group exhibited no significant changes.
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  • - The rise of electronic communication technology has caused significant electromagnetic pollution, leading researchers to explore materials for electromagnetic shielding.
  • - A method called melt blending was used to create iPP/TPU/MWCNT nanocomposites that demonstrated strong electromagnetic shielding abilities.
  • - By adjusting the composition and incorporation of materials like maleic anhydride-grafted polypropylene and multi-walled carbon nanotubes, the study achieved a maximum electromagnetic interference (EMI) shielding efficiency of 37.8 dB.
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Wild-type Lactococcus lactis strain LAC460 secretes prophage-encoded bacteriocin-like lysin LysL, which kills some Lactococcus strains, but has no lytic effect on the producer. LysL carries two N-terminal enzymatic active domains (EAD), and an unknown C-terminus without homology to known domains. This study aimed to determine whether the C-terminus of LysL carries a cell wall binding domain (CBD) for target specificity of LysL.

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  • * This study found that B. adolescentis reduces AILI in mice by producing a microbial metabolite called hypaphorine, which helps lower inflammation and oxidative stress in the liver.
  • * Additionally, hypaphorine treatment increased the expression of the Cry1 gene, which is associated with protecting against liver damage, a correlation also observed in patients with acute liver failure.
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  • - The study examined how walnut peptides and a specific peptide (YP-7) protect against memory loss caused by scopolamine and damage from β-amyloid in mice and neurons.
  • - Results showed that YP-7 enhances learning and memory in mice while preserving the health of their brain cells, as evidenced by behavioral tests and brain slice analysis.
  • - The protective effects of YP-7 involve activating PPARγ, which helps neurons resist damage by regulating certain signaling pathways, suggesting potential for using these peptides in functional foods for brain health.
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