Publications by authors named "YanRong Lin"

Background: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive lung disease. Disulfidptosis-related genes (DRGs) may be involved in the pathogenesis of COPD. From the perspective of predictive, preventive, and personalized medicine (PPPM), clarifying the role of disulfidptosis in the development of COPD could provide a opportunity for primary prediction, targeted prevention, and personalized treatment of the disease.

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  • - The study aimed to evaluate how effective nanopore sequencing technology is for diagnosing tuberculous meningitis (TBM) using cerebrospinal fluid samples from patients.
  • - Compared to traditional methods like acid-fast staining and culture, nanopore sequencing had a sensitivity of 43.30% and an area under the ROC curve of 0.661, indicating better performance overall.
  • - When nanopore sequencing was used alongside imaging techniques, it achieved the best diagnostic results with increased sensitivity, specificity, and predictive values, showing its potential as a reliable tool for TBM diagnosis.
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  • The study aimed to assess how effective third-generation nanopore sequencing is for diagnosing pulmonary tuberculosis (TB) in patients with diabetes mellitus suspected of having the disease.
  • Researchers collected samples from patients and compared nanopore sequencing results to traditional diagnostic methods like acid-fast bacilli smear and Xpert MTB/RIF.
  • Findings showed that nanopore sequencing significantly enhanced diagnostic accuracy and sensitivity, especially when used in combination with Xpert testing, indicating it could be a better option for TB detection in diabetic patients.
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  • SARS-CoV-2 variants pose a serious health threat, leading to high rates of illness and death, prompting the need for genomic analysis.
  • Next-generation sequencing and phylogenetic analysis were used to study 80 SARS-CoV-2 genomes from COVID-19 patients, revealing a novel variant with specific mutations in the spike glycoprotein.
  • These mutations (H625R and S50L) could enhance the spike protein's flexibility and potentially alter its interaction with the ACE2 receptor, indicating ongoing evolution of the virus.
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The substitution of chemical nitrogen fertilizer with manure holds the potential for a synergistic rise in wheat grain yield and protein concentration, while minimizing residual nitrate in soil. We conducted a 6-year field fertilization experiment including two manure treatments (with or without) and five nitrogen applications rates (0, 60, 120, 180 and 240 kg ha). The study investigated the impact of single chemical nitrogen (CN) and manure substitution for nitrogen fertilizer (MN) on the grain yield (GY), grain protein concentration (GPC), plant nitrogen uptake (PNupt) and plant nitrogen requirement (PNR) of wheat, and the dynamic change of soil nitrate-N.

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To evaluate the effects of nitrogen (N) application rates on the growth, photosynthetic traits and yield of winter wheat under elevated atmospheric ammonia (NH) concentrations could provide guidance for N management under high NH environment. We conducted a split-plot experiment for two consecutive years (2020-2021 and 2021-2022) with top-open chambers. The treatments included two NH concentrations [elevated ambient NH concentration at 0.

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  • * A study analyzed 118 patients with confirmed SARS-CoV-2 infections to assess various clinical indicators during their hospital stay.
  • * Findings revealed that specific blood markers (high ALT, AST, low CD4+, CD8+) correlated with a longer duration of detectable viral RNA, suggesting these indicators may help predict how long a patient will carry the virus.
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Severe acute respiratory syndrome coronavirus 2 infection is associated with strong infectiousness and has no effective therapy. We aimed to explore the efficacy and safety of nebulization in the treatment of Coronavirus Disease 2019 (COVID-19). In this randomized, double-blind, placebo-controlled clinical trial, we included 31 adult patients with moderate COVID-19 who were admitted to the Fourth People's Hospital of Nanning (Nanning, China) between January 22, 2020 and February 17, 2020.

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Objective: To discuss the effective of artesunate in the treatment of coronavirus disease 2019 (COVID-19).

Methods: Using prospective method, the 43 cases of confirmed COVID-19 patients in Nanning Fourth People's Hospital from January 22nd to February 15th in 2020 were enrolled and divided into routine treatment group (n = 25) and artesunate treatment group (n = 18) by odd-even rule after admission. According to the guidelines, the routine treatment group was recommended to receive lopinavir/ritonavir 500 mg + α-aerosolized interferon 500×10 U, twice daily; the artesunate treatment group was given artesunate 60 mg, twice daily besides the routine treatment, for 10 days in both groups.

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Objective: To investigate the clinical features, laboratory results, chest CT imaging manifestations and treatments of severe and critical influenza A (H1N1), and to analyze the relationship with the prognosis.

Methods: The clinical data of 54 adult patients with severe and critical H1N1 admitted to the Fourth People's Hospital of Nanning from November 2018 to February 2019 were analyzed retrospectively. Throat swab specimens of the patients were determined for nucleic acid detection of influenza A (H1N1) virus, and all of the patients were confirmed.

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Background: Degradable collagen-chitosan composite materials have been used to fabricate tissue engineered heart valves. The aims of this study were to demonstrate that the collagen-chitosan composite scaffolds are cytocompatible, and endothelial cells can be differentiated from bone marrow mesenchymal stem cells (BMSCs) when seeded onto the scaffolds. The adhesion and biological activities of the seeded cells were also investigated.

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