The burden of injury among elderly individuals in China from 1990 to 2019: An analysis of data from the global burden of disease study 2019.

Background: With the rapid ageing of the population, injuries are increasingly threatening the health of elderly individuals. A comprehensive evaluation of the injury burden is important for selecting and formulating strategies for injury prevention.

Objective: To evaluate the temporal trends of injury burden among elderly Chinese individuals aged 60 years and older.

Exploration and verification of circulating diagnostic biomarkers in osteoarthritis based on machine learning.

Background: Osteoarthritis (OA) is a prevalent chronic joint condition. This study sought to explore potential diagnostic biomarkers for OA and assess their relevance in clinical samples.

Methods: We searched the GEO database for peripheral blood leukocytes expression profiles of OA patients as a training set to conduct differentially expressed gene (DEG) analysis.

[Application and progress of intelligent responsive hydrogels in articular cartilage injury repair].

Objective: To review clinical application and research progress of different types of intelligent responsive hydrogels in repairing articular cartilage injury.

Methods: The animal experiments and clinical studies of different types of intelligent responsive hydrogels for repairing articular cartilage injury were summarized by reviewing relevant literature at home and abroad.

Results: The intrinsic regenerative capacity of articular cartilage following injury is limited.

Gut microbiota causes depressive phenotype by modulating glycerophospholipid and sphingolipid metabolism via the gut-brain axis.

Emerging evidence suggests that changes in the gut microbiota (GM) are related to prenatal depression onset, but the underlying molecular mechanisms remain obscure. This study was conducted to explore how disordered GM is involved in the onset of prenatal depression through the microbiome-gut-brain (MGB) axis. We transplanted fecal microbiota from women with and without prenatal depression into germ-free mice.

Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis.

Background And Aims: Recent studies have indicated possible links between the microbiota and the fetal heart, while the relevant mechanism is still unknown. This study is aims to investigate whether analyzing the microbiota and metabolic profiles of amniotic fluid collected from pregnant women whose fetuses with or without non-syndromic congenital heart defects (CHDs), during the second and third trimester of pregnancy, could offer valuable insights into CHDs.

Methods And Results: A case-control study was conducted with 17 cases diagnosed with non-syndromic CHDs (CHDs group) and 34 controls without congenital anomalies (control group) at a ratio of 1:2.

Influences of Rearing Season, Host Plant, and Silkworm Species on Gut Bacterial Community.

The gut bacterial community plays many important roles in the production of nutrients and digestion. and (Lepidoptera: Saturniidae) are two traditional sources of human food, as well as being silk-producing insects. In the present study, the influences of rearing season (spring and autumn), silkworm species ( and ), and host plant ( and ) on gut microbiota diversity were tested using Illumina MiSeq technology.

Effect of the thinking healthy programme-based internet intervention model for maternal perinatal depression: A pilot study.

Background: Thinking Healthy Programme (THP) is an evidence-based psychosocial intervention that can be delivered by non-psychologists and does not require the implementer to have a mental health background or field experience. The THP has been tested in maternal health in many countries. However, the application of the THP model in Chinese maternal and child health has not been reported.

The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates.

Drought induced by climate change poses a serious threat to human health. The gut microbiome also plays a critical role in human health. However, no studies have explored the effect of drought on the human gut microbiome.

Ultra-Photostable Bacterial-Seeking Near-Infrared CPDs for Simultaneous NIR-II Bioimaging and Antibacterial Therapy.

Bacterial infections can pose significant health risks as they have the potential to cause a range of illnesses. These infections can spread rapidly and lead to complications if not promptly diagnosed and treated. Therefore, it is of great significance to develop a probe to selectively target and image pathogenic bacteria while simultaneously killing them, as there are currently no effective clinical solutions available.

Determinations of methylmercury and mercury methylation/demethylation rate constants in environmental samples using isotope dilution/tracing methods by automatic ethylation-purge and trap-GC-ICP-MS.

Background: Mercury (Hg), especially methylmercury (MeHg) as a most toxic format of Hg in the environment, has been paid widely concern due to its high bioaccumulative capability and great risk to humans. Great efforts have been made to develop ethylation-purge and trap-gas chromatography-inductively coupled plasma mass spectrometry system for MeHg analysis and Hg biogeochemical cycling investigation. However, the generally manual operation limits the analytical efficiency, and the lack of applications in the real environmental samples restricts the future study.

Prenatal ozone exposure and variations of the gut microbiome: Evidence from a Chinese mother-infant cohort.

Background: The gut microbiome is central to human health, but the potential impact of ozone (O) exposure on its establishment in early life has not been thoroughly examined. Therefore, this study aimed to investigate the relationship between prenatal O exposure and the variations of the human gut microbiome during the first two years of life.

Design: A cohort study design was used.

Time-varying ambient air pollution exposure is associated with gut microbiome variation in the first 2 years of life.

The infant gut microbiome matures greatly in the first year of life. Ambient air pollution (AAP) exposure is associated with the infant gut microbiome. However, whether time-varying AAP influences infant gut microbiome variation is rarely investigated.

Clinical efficacy and pain follow-up after arthroscopic discoid meniscoplasty of the knee: a retrospective study.

Background: To assess the viability and efficiency of performing arthroscopic meniscoplasty in treating discoid meniscus (DM) in the knee joint.

Methods: A total of 29 patients diagnosed with symptomatic lateral DM between October 2014 and December 2019 were included in the study. Among them, 7 patients with intact DM underwent arthroscopic discoid meniscoplasty (group A), while 22 patients with torn DM received arthroscopic DM plasty along with repair and suturing (group B).

Needle breakage as an unusual complication of intravenous therapy: A case report.

Residual intravenous foreign bodies following hand trauma are relatively rare; only a few previous reports of this situation are available. It has been reported that foreign bodies often migrate to the heart and atrium dextrum. Herein, we report a recent case of needle breakage in the dorsal vein of the hand that was removed with lignification using an intraoperative C-arm fluoroscopy machine and tape tourniquet to avoid proximal movement during removal.

The mediating effect of maternal gut microbiota between prenatal psychological distress and neurodevelopment of infants.

Background: Prenatal psychological distress and maternal inflammation can increase the risk of neurodevelopmental delay in offspring; recently, the gut microbiota has been shown to may be a potential mechanism behind this association and not fully elucidated in population study.

Methods: Seventy-two maternal-infant pairs who completed the assessments of prenatal psychological distress during the third trimester and neurodevelopment of infants at age 6-8 months of age were included in this study. The gut microbiota and its short-chain fatty acids (SCFAs) of maternal-infant were determined by 16S rRNA sequencing and liquid chromatography-mass spectrometry analysis.

Prenatal Gut Microbiota Predicts Temperament in Offspring at 1-2 Years.

The purpose of this study was to explore whether prenatal gut microbiota (GM) and its functions predict the development of offspring temperament. A total of 53 mothers with a 1-year-old child and 41 mothers with a 2-year-old child were included in this study using a mother-infant cohort from central China. Maternal fecal samples collected during the third trimester were analyzed using 16S rRNA V3-V4 gene sequences.

Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia.

The gut microbiome has been reported to be associated with nighttime light (NTL) exposure and temperament. However, the specific role of infant gut microbiome plays in NTL exposure and temperament is unclear. This study investigated the potential mediating role of infants' gut microbiome in correlations between NTL exposure and temperament.

Short-term exposures to PM, PM chemical components, and antenatal depression: Exploring the mediating roles of gut microbiota and fecal short-chain fatty acids.

Background: PM and its chemical components increase health risks and are associated with depression and gut microbiota. However, there is still limited evidence on whether gut microbiota and short-chain fatty acids (SCFAs) mediate the association between PM, PM chemical components, and antenatal depression. The purpose of this study was to investigate the mediating role of maternal gut microbiota in correlations between short-term exposure to PM, short-term exposure to PM chemical components, and antenatal depression.

Bioconcentration of Inorganic and Methyl Mercury by Algae Revealed Using Dual-Mass Single-Cell ICP-MS with Double Isotope Tracers.

Algae are an entry point for mercury (Hg) into the food web. Bioconcentration of Hg by algae is crucial for its biogeochemical cycling and environmental risk. Herein, considering the cell heterogeneity, we investigated the bioconcentration of coexisting isotope-labeled inorganic (IHg) and methyl Hg (MeHg) by six typical freshwater and marine algae using dual-mass single-cell inductively coupled plasma mass spectrometry (scICP-MS).

The Potential of Natural Carotenoids-Containing Sericin of the Domestic Silkworm .

Sericin derived from the white cocoon of has been attracting more attention for its utilization in food, cosmetics, and biomedicine. The potential health benefits of natural carotenoids for humans have also been well-established. Some rare strains of () produce yellow-red cocoons, which endow a potential of natural carotenoid-containing sericin.

More potential uses of specific perforator flaps in the calf - A cadaveric study on the subdermal vascular structure of the lower leg.

Background: The perforator flap has garnered significant interest since its inception due to its advantage of not needing a vascular network at the deep fascial level. Perforator flaps are commonly utilized in different flap transplant surgeries, and the thigh flap is presently the most widely used perforator flap. Is it possible for the calf to replace the thigh as a more suitable site for harvesting materials? Currently, there is a lack of relevant anatomical research.

Analysis of network expression and immune infiltration of disulfidptosis-related genes in chronic obstructive pulmonary disease.

Background: Chronic obstructive pulmonary disease (COPD) is a globally prevalent respiratory disease, and programmed cell death plays a pivotal role in the development of COPD. Disulfidptosis is a newly discovered type of cell death that may be associated with the progression of COPD. However, the expression and role of disulfidptosis-related genes (DRGs) in COPD remain unclear.

Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR /SRC pathway in vascular cognitive impairment mice.

Aim: To explore the neuroprotective potential of hyperforin and elucidate its underlying molecular mechanisms involved in its therapeutic effects against vascular cognitive impairment (VCI).

Methods: The active compounds and possible targets of Hypericum perforatum L. that may be effective against VCI were found by network pharmacology in this research.