MicroRNA-450b-5p modulated RPLP0 promotes hepatocellular carcinoma progression via activating JAK/STAT3 pathway.

Hepatocellular carcinoma (HCC) is distinguished by its insidious onset, difficult treatment, and poor prognosis. Ribosomal Protein Lateral Stalk Subunit P0 (RPLP0) is implicated in numerous tumor progression processes. Nevertheless, the regulatory mechanism of RPLP0 in HCC progression remains unclear.

SNX16 is required for hepatocellular carcinoma survival via modulating the EGFR-AKT signaling pathway.

Sorting nexin 16 (SNX16), a pivotal sorting nexin, emerges in tumor progression complexity, fueling research interest. However, SNX16's biological impact and molecular underpinnings in hepatocellular carcinoma (HCC) remain elusive. This study probes SNX16's function, clinical relevance via mRNA, and protein expression in HCC.

KLF4 Induces Colorectal Cancer by Promoting EMT via STAT3 Activation.

Objective: Krüppel-like factor 4 (KLF4) has been demonstrated to exert a pro-carcinogenic effect in solid tissues. However, the precise biological function and underlying mechanisms in colorectal cancer (CRC) remains elucidated.

Aims: To investigate whether KLF4 participates in the proliferation and invasion of CRC.

Design, synthesis, and anti-tumor activity of derivatives of ring A and C-28 of asiatic acid.

Based on computer-aided drug design (CADD), the active groups of the known active small molecule compounds that can bind to EGFR target protein were analyzed through the molecular docking method. Then, 12 novel asiatic acid derivatives were synthesized by introducing active groups at ring A and C-28 positions of asiatic acid. The structures of these novel compounds were determined by NMR and MS.

Design, synthesis, and antitumor activity of novel oleanolic acid analogues targeting EGFR.

Based on the simulated docking of Epidermal growth factor receptor inhibitors with known active small molecule compounds, computer-aided drug design technology was used to analyze key amino acid fragments and determine the active groups binding with key sites. Then, twelve novel analogues of oleanolic acid (OA) were synthesized by introducing active groups at the C-3 and C-28 positions of OA. The structures of these novel analogues were confirmed by NMR and MS.

Synthesis and anti-tumor activity of asiatic acid derivatives targeting VEGFR.

To discovery novel VEGFR inhibitors, 12 novel asiatic acid derivatives were designed by computer-aided drug design (CADD) technology. Then, these novel asiatic acid derivatives were synthesized by introducing active groups at ring A and C-28 positions of asiatic acid. The structures of these novel analogues were confirmed by NMR and MS.

Design, synthesis and anti-tumor activity of asiatic acid derivatives as VEGF inhibitors.

The VEGF receptor is mock-coupled with a known active compound and the active groups of the inhibitor which can bind to VEGF were analyzed. Using asiatic acid as a lead compound, 10 novel skeleton candidate compounds were designed through introduction of the active groups onto the special location and synthesized simultaneously. Furthermore, the structure of these compounds was determined by H NMR, C NMR and MS and 9 compounds were identified as the new compounds.

Design, synthesis and bioactivities evaluation of novel oleanolic acid derivatives as potent PI3K inhibitors.

Oleanolic acid has previously been shown to possess PI3K inhibitory activity, thus, the purpose of this work was to generate a series of derivatives that improve the potency. Twenty rationally designed oleanolic acid derivatives were synthesized and tested the cytotoxicity and PI3K inhibitory activity. The results suggested that attachment of additional structural elements such as association of thiazole group to A ring and insertion of phenylurea group was important for increasing activities.

Discovery of Potent Glucokinase and PPARγ Dual-Target Agonists through an Innovative Scheme for Regioselective Modification of Silybin.

Glucokinase (GK) and PPARγ are important targets for antidiabetic use. Silybin is one of the major active ingredients of . The regioselective modification of the five hydroxyl groups in the silybin structure has always been a challenge.

Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis.

Recent studies have illustrated the role of aberrant regulatory interactions in the mediation of malignant phenotypes of cancer cells, which could potentially provide novel therapeutic targets to limit the destructive recurrence and metastasis of hepatocellular carcinoma (HCC). Herein, we clarify the oncogenic role of the long noncoding RNA (lncRNA) distal-less homeobox 6 antisense 1 (DLX6-AS1) in HCC in vivo and in vitro. To this end, we knocked down lncRNA DLX6-AS1 and manipulated the expression of miR-513c to characterize their effects in HCC cell viability, migration, invasion, and apoptosis.

Synthesis of oleanolic acid analogues targeting PDGF receptor inhibitors and their antitumor biological activities.

The PDGF receptor is mock-coupled with a known active compound, and 14 novel skeleton candidate compounds were designed and synthesized. The structure was confirmed by H NMR, C NMR and MS. The cytotoxicity of the two cancer cell lines (SGC-7901 and A549) was evaluated by MTT assay.

Design and synthesis of VEGFR-2 inhibitors based on oleanolic acid moiety.

In this study, twenty-four oleanolic acid (OA) derivatives were rationally designed based on molecule docking studies and their VEGFR-2 inhibitory activities were tested by Homogeneous time-resolved fluorescence (HTRF) method . All of the synthesized compounds were identified as new compounds, and the structures of these compounds were determined by H-NMR and ESI-MS. In the screening for VEGFR-2 inhibitors, compounds and exhibited excellent inhibitory effect.

Synthesis and anti-tumor activity of derivatives of ring A of asiatic acid.

Based on the simulation of the docking of survivin protein with known small molecule inhibitors, the active groups which can bind to target proteins were analyzed by the techniques of computer-aided drug design (CADD). These active groups were introduced into the A-ring of asiatic acid and their C-28 sites were reconstructed simultaneously. Ten asiatic acid derivatives were designed and synthesized, and their structures were confirmed by MS and NMR.

Synthesis and antitumor activity evaluation of ursolic acid derivatives.

Eighteen uronic acid derivatives were designed and synthesized, and the cytotoxicities of two cancer cell lines (BEL7402 and SGC7901) were evaluated by MTT assay. The results showed that the inhibitory rate of the compounds on both cell lines was significantly higher than the parent compound. The IC of compounds II, II, III, and III are comparable or stronger than the positive control drug, the interactions between compounds II, II, III, III, and NF-κB were also studied by docking simulations.

The associations between left-hand digit ratio (2D:4D) and puberty characteristics among Chinese girls.

Background: The aim of this study was to analyse the associations of left-hand digit ratio (2D:4D), digit length and puberty characteristics to show the role of prenatal hormones in development among Chinese girls.

Method: A total of 318 Chinese girls aged 8-15 years were recruited using a stratified cluster sampling method. The index finger (2D), ring finger (4D) of the left hand, oestradiol and testosterone were measured, and age at menarche (AAM), breast (high and low) and pubic hair (high and low) development were recorded.

The association between digit ratio (2D:4D) and blood pressure among children and adolescents.

Digit ratio (2D:4D) is a biomarker of prenatal hormone exposure levels; this biomarker is negatively related to prenatal androgen exposure and positively related to prenatal estrogen exposure. We investigated the correlation between digit ratio (2D:4D) and blood pressure. A school-based survey of 687 adolescents aged 8-15 years was conducted.

Construction of TiO Nanotubes/C/MnO Composite Films as a Binder-Free Electrode for a High-Performance Supercapacitor.

Although titanium dioxide (TiO) exhibits excellent promise in electrode materials for supercapacitors, its poor conductivity and low areal specific capacitance hamper further development. In this work, we have designed a clever way to deposit manganese dioxide (MnO) in order to improve its electrochemical performance via a facile and typical hydrothermal method. In a hydrothermal process, carbon (C), which deposited via new gas thermal penetration, acts as a reducing agent, while a potassium permanganate (KMnO) solution acts as an oxidant.

Computational investigation of TGF-β receptor inhibitors for treatment of idiopathic pulmonary fibrosis: Field-based QSAR model and molecular dynamics simulation.

The discovery of drugs relevant to transforming growth factor β (TGF-β) receptor inhibitors have been considered as a considerable challenge during therapy idiopathic pulmonary fibrosis diseases. For the first time, herein we illustrate a field-based quantitative structure-activity relationship (QSAR) model and molecular dynamics (MD) simulations for novel 7-substituted-pyrazolo [4, 3-b] pyridine derivatives with biological activity for the TGF-β receptor, with an attempt of elucidating the 3D structural features that are essential for the activity. Results demonstrate that the field-based model (Q = 0.

[Association of aggressive behavior with separation from parents and social anxiety in grade four to six of rural senior primary school students in Anhui Province in 2014].

Objective: To explore the relationship between separation from parents and social anxiety with aggressive behaviors, to provide scientific basis for the prevention of aggression.

Methods: Stratified random sampling was used to collect 1126 students ofthe fourth, fifth and sixth grade from three primary schools in Dangshan County and two primary schools in Guzhen County. The incomplete or incorrect questionnaires were eliminated, and 1024 questionnaires were valid; the effective rate was 90.

Design, synthesis, and antitumor activity of oleanolic acid derivatives.

Using the techniques of computer-aided drug design, the docking of survivin and known active small molecules was simulated and then the key amino acid residue fragments of the target protein were analyzed. It led to the discovery of active groups capable of binding to the critical sites. Through the use of the natural product, oleanolic acid, as a lead compound, the introduction of the active groups onto the A-ring, and the modification of the carboxyl group at the C-28 position using esterification or amidation, 20 new oleanolic acid derivatives had been designed and synthesized.

The association between digit ratio (2D:4D) and the first spermatorrhea among Chinese boys.

Background: The second-to-fourth digit ratio (2D:4D) is a marker of prenatal hormone exposure, which is negatively correlated with prenatal androgen and positively correlated with prenatal estrogen. The study was to analyze the association between 2D:4D and the first spermatorrhea to indirectly show the possible role of prenatal hormone during puberty development among boys.

Method: The total of 367 boys aged 8-15 years were enrolled by using the stratified cluster sampling method.

Synthesis and antitumor activity evaluation of asiatic acid derivatives as survivin inhibitor.

A series of asiatic acid derivatives were synthesized and their cytotoxicities in vitro against two cancer cell lines (HepG2 and SGC7901) were evaluated by MTT assay. The results showed that compounds I, I, and II have more potent anticancer activity than that of the positive control drug paclitaxel. The interactions between the compounds I, I, and II and survivin were also studied by docking simulations.

Synthesis and antitumor activity evaluation of novel oleanolic acid derivatives.

Ten novel oleanolic acid (OA) derivatives were synthesized through modifications at positions of A ring and C-28. Inhibitory activities of the oleanolic acid derivatives against SGC7901 and A549 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines.

Synthesis and antitumor activity evaluation of novel ursolic acid derivatives.

Eleven novel ursolic acid (UA) derivatives were designed and synthesized with modification at positions of C-2, C-3, and C-28 of UA. Their structures were confirmed by MS, (1)H NMR, and elemental analysis. Their in vitro cytotoxicities against various cancer cell lines (HeLa, HepG2, and BGC-823) were evaluated by MTT assay.