Visual colorimetric label for real-time monitoring of SO concentration change in grape and mango during storage.

Sulfur dioxide (SO) is widely utilized as a preservative in food transportation and storage, but excessive consumption poses health risks. This study presents a novel and efficient method for the real-time detection of SO using a sensor named TK, synthesized from triphenylamine and 2-cyanomethyl-1-methyl-quinolinium. The core mechanism involves the Michael addition reaction of the CC bond in TK with SO, which disrupts the intramolecular charge transfer process, resulting in a significant color change and a blue shift in fluorescence emission.

A near-infrared lysosomal probe for dynamic sulfur dioxide monitoring in inflammation.

Inflammation is a complex physiological response involving various cellular and molecular events. Sulfur dioxide (SO), recognized as both an endogenous signaling molecule and anti-inflammatory agent, plays a crucial role in modulating inflammation and maintaining cellular homeostasis. To gain deeper insights into the dynamics of inflammation-related processes, real-time monitoring of SO concentrations within cellular organelles is imperative.

A flexible nanofiber membrane containing dendritic oxygen probe for visual monitoring pressure distribution.

Pressure-sensitive paints (PSP) enable non-intrusive visualization of surface pressure distribution on model surface which is important for aerodynamic studies. However, conventional PSP materials suffer from photobleaching and inadequate sensitivity. In this work, we rationally designed and synthesized novel dendritic oxygen probes (PT1 and PT2) by covalently grafting fluorinated dendrons onto platinum tetrakis(pentafluorophenyl)porphyrin (PT0) (a common oxygen probe).

Development of a rapid and sensitive fluorescent probe for high-throughput detecting SO in food samples.

Sulfur dioxide (SO), widely used as an antioxidant and preservative in food production, has been associated with detrimental cardiovascular and neurological effects when consumed excessively. This highlights the pressing need to develop a fast and sensitive probe capable of high-throughput screening for the quantitative determination of SO in food. Herein, we synthesized a new fluorescent probe, namely B3, specifically designed for high-throughput detection of SO in food.

A near-infrared probe for the real-time detection of lysosomal pH in living cells under "wash free" conditions.

Lysosomal pH is an important indicator for the physiological state of eukaryotic cells. The real-time detection of intracellular lysosomal pH is critical for understanding and studying many physiological and pathological processes of cells. Herein, we designed and synthesized a series of novel pH sensors, namely W1, W2 and W3.

Integrated Ideal-Bandgap Perovskite/Bulk-Heterojunction Solar Cells with Efficiencies > 24.

Here, the authors report a highly efficient integrated ideal-bandgap perovskite/bulk-heterojunction solar cell (IPBSC) with an inverted architecture, featuring a near infrared (NIR) polymer DTBTI-based bulk-heterojunction (BHJ) layer atop guanidinium bromide (GABr)-modified FA MA Pb Sn I perovskite film as the photoactive layer. The IPBSC shows cascade-like energy level alignment between the charge-extractionlayer/perovskite/BHJ and efficient passivation effect of BHJ on perovskite. Thanks to the well-matched energy level alignment and high-quality ideal bandgap-based perovskite film, an efficient charge transfer occurs between the charge-extraction-layer/perovskite/BHJ.

New nanostructured extracellular potassium ion probe for assay of cellular K transport.

The concentration of potassium ion is an important indicator for human health, and its abnormality is often accompanied by various diseases. However, most tools currently used to study potassium ion transport are low throughput. Herein, we reported a new K fluorescent nanoprobe CP1-KS with high selectivity and sensitivity to K (fluorescence enhanced factor was up to 9.

Magnetically Reusable and Well-dispersed Nanoparticles for Oxygen Detection in Water.

In this study, we aimed to synthesize magnetically well-dispersed nanosensors for detecting dissolved oxygen (DO) in water, and explore their biological applications. Firstly, we synthesized two kinds of magnetic nanoparticle with average sizes of approximately 82 nm by one-step emulsion polymerization: polystyrene magnetic nanoparticles (FeO@Os1-PS) and polymethylmethacrylate magnetic nanoparticles (FeO@Os1-PMMA). Both types of nanoparticle present good dispersibility and fluorescence stability.

A Dual pH/O Sensing Film Based on Functionalized Electrospun Nanofibers for Real-Time Monitoring of Cellular Metabolism.

Real-time monitoring of dissolved oxygen (DO) and pH is of great significance for understanding cellular metabolism. Herein, a dual optical pH/O sensing membrane was prepared by the electrospinning method. Cellulose acetate (CA) and poly(ε-caprolactone) (PCL) nanofiber membrane blended with platinum (II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was used as the DO sensing matrix, upon which electrospun nanofiber membrane of chitosan (CS) coupled with fluorescein 5-isothiocyanate (FITC) was used as the pH sensing matrix.

Rational Design of a Polymer-Based Ratiometric K Indicator for High-Throughput Monitoring Intracellular K Fluctuations.

Highly selective fluorescent K sensors are of great importance for monitoring K fluctuations in various biological processes. In particular, highly efficient ratiometric K sensors that can emit in dual wavelengths and facilitate the quantitative determination of K are highly anticipated. Herein, we present the first polymer-based ratiometric fluorescent K indicator () for quantitatively detecting K in aqueous solutions and high-throughput monitoring K fluctuations in living cells.

Effectiveness of a case management model in newly treated smear-positive pulmonary tuberculosis patients.

Introduction: To investigate the effectiveness of the case management mode on the application of smear-positive pulmonary tuberculosis patients.

Methodology: This was a randomized control trial. A total of 70 newly diagnosed smear-positive pulmonary tuberculosis patients were recruited and been randomly divided into experimental group and control group, with 35 participants in each group.

GdDO3NI Enhanced Magnetic Resonance Imaging Allows Imaging of Hypoxia After Brain Injury.

Background: Brain tissue hypoxia is a common consequence of traumatic brain injury (TBI) due to the rupture of blood vessels during impact and it correlates with poor outcome. The current magnetic resonance imaging (MRI) techniques are unable to provide a direct map of tissue hypoxia.

Purpose: To investigate whether GdDO3NI, a nitroimidazole-based T MRI contrast agent allows imaging hypoxia in the injured brain after experimental TBI.

Automatic light-adjusting electrochromic device powered by perovskite solar cell.

Electrochromic devices can modulate their light absorption under a small driving voltage, but the requirement for external electrical supplies causes response-lag. To address this problem, self-powered electrochromic devices have been studied recently. However, insensitivity to the surrounding light and unsatisfactory stability of electrochromic devices have hindered their critical applications.

Characterization and elimination of artificial non-covalent light Chain dimers in reduced CE-SDS analysis of pertuzumab.

Capillary electrophoresis sodium dodecyl sulfate (CE-SDS), either in reduced (rCE-SDS) or non-reduced (nrCE-SDS) form, is widely used for purity evaluation and impurity analysis of monoclonal antibody (mAb) drugs. The accuracy of the method may be interfered by artificial species resulted from sample preparation or electrophoresis operation if it is not well optimized. In a routine analysis of pertuzumab for both innovator Perjeta® and biosimilar HLX11 samples, a cluster of unknown peaks located between light chain (LC) and heavy chain (HC) were observed in rCE-SDS and making the purity of (LC + HC)% unacceptable.

Close Temporal Relationship between Oscillating Cytosolic K and Growth in Root Hairs of .

Root hair elongation relies on polarized cell expansion at the growing tip. As a major osmotically active ion, potassium is expected to be continuously assimilated to maintain cell turgor during hair tip growth. However, due to the lack of practicable detection methods, the dynamics and physiological role of K in hair growth are still unclear.

Polymer matrix: A good substrate material for oxygen probes used in pressure sensitive paints.

Over the past few years, surface pressure measurement has fundamental importance in many areas, particularly, aerodynamic research. Conventional methods involve pressure taps, but due to the nature of these pressure taps, only pressure information of isolated points on model surface is available, which limit their applications in aerodynamics studies. Recently the newly developed approach, pressure sensitive paint (PSP) has revolutionized such pressure measurements and various PSP materials have been developed for aerodynamics research.

Electron/energy co-transfer behavior and reducibility of Cu-chlorophyllin-bonded carbon-dots.

Cu-chlorophyllin-bonded carbon dots (CCPh-CDs) have been synthesized at room temperature, and the energy/electron co-transfer behavior between Cu-chlorophyllin molecules (CCPh) and carbon dots (CDs) is investigated various techniques. The mean diameters of CDs and CCPh-CDs are 2.8 nm and 3.

Development of a molecular K probe for colorimetric/fluorescent/photoacoustic detection of K.

The potassium ion (K) plays significant roles in many biological processes. To date, great efforts have been devoted to the development of K sensors for colorimetric, fluorescent, and photoacoustic detection of K separately. However, the development of molecular K probes for colorimetric detection of urinary K, monitoring K fluxes in living cells by fluorescence imaging, and photoacoustic imaging of K dynamics in deep tissues still remains an open challenge.

A mitochondria-targeting NIR fluorescent potassium ion sensor: real-time investigation of the mitochondrial K regulation of apoptosis in situ.

The first NIR fluorescent mitochondria-targeting K+ sensor, denoted as TAC-Rh, was developed. The produced sensor consists of a rhodamine analog as the fluorophore and triazacryptand (TAC) as the K+ recognition unit. Compared to the K+ sensors reported previously, TAC-Rh exhibits two unique optical properties: the largest Stokes shifts (120 nm) and the longest emission peak wavelength (720 nm).

Tricolor dual sensor for ratiometrically analyzing potassium ions and dissolved oxygen.

A potassium ion‑oxygen (K-O) dual fluorescent sensing film was developed. The film contains three probes, which are K probe (KS), O probe (OS), and reference probe (RP) in a polymer film composed of poly(ethylene glycol) methyl ether methacrylate (PEGMA), poly(ethylene glycol) dimethacrylate (PEGDMA) and methacrylic acid (MAA). The RP showed blue emission, the KS exhibited green emission, and the OS showed red emission.

cRGD functionalized 2,1,3-benzothiadiazole (BTD)-containing two-photon absorbing red-emitter-conjugated amphiphilic poly(ethylene glycol)-block-poly(-caprolactone) for targeted bioimaging.

A two-photon absorbing (2PA) red emitter group was chemically conjugated onto amphiphilic poly(ethylene glycol)--poly(-caprolactone) (PEG--PCL) copolymers, and further grafted with cyclo (Arg-Gly-Asp) (cRGD) peptide to form micelle 1. Micelle 1 with cRGD targeting groups were used for targeted bioimaging. For comparison, micelle 2 without the cRGD targeting groups were also prepared and investigated.

Easily Synthesized Polyaniline@Cellulose Nanowhiskers Better Tune Network Structures in Ag-Based Adhesives: Examining the Improvements in Conductivity, Stability, and Flexibility.

It is essential to develop a novel and versatile strategy for constructing electrically conductive adhesives (ECAs) that have superior conductivity and high mechanical properties. In this work, easily synthesized polyaniline@cellulose (PANI@CNs) nanowhiskers with a high aspect ratio and excellent solubility in 1,4-dioxane were prepared and added to conventional Ag-containing adhesives. A small amount of PANI@CNs can dramatically tune the structure of the ECAs' conductive network and significantly improve the conductivity of the ECAs.

Excellent Adsorptive Behaviors of ZnO Nanoparticle-Deposited Activated Carbon Covered with Nano-Graphene Oxide.

In the paper, ZnO-deposited activated carbon composite (ZnO-AC) was firstly prepared in a simple two-step preparation process, and then covered with nano-graphene oxide to give the NGO-ZnOAC composite. The successful deposition of ZnO and NGO on the AC surface was demonstrated by various experiments, and the ZnO nanoparticles showed a mean diameter size mainly within about 10 nm. The specific surface area of the NGO-AC and NGO-ZnO-AC decreased from 67.

Carbon Nanotubes with Carbon Blacks as Cofillers to Improve Conductivity and Stability.

In this study, a simple solution-mixing method is used to develop a kind of excellent flexible, electrically conductive adhesives (ECAs). Carbon nanotubes (CNTs) and carbon blacks (CBs) as cofillers were added into Ag-based pastes. The use of the two fillers is due to the consideration that these two materials may provide positive synergistic effects for improving the conductivity of ECAs.