Development and validation of non-invasive prediction models for assessing kidney histopathological activity index in lupus nephritis.

Objective: To develop and validate prediction models for estimating the activity index (AI) of kidney histopathology in lupus nephritis (LN) using clinical and laboratory data.

Methods: This study used single-center data from patients with kidney biopsy-confirmed LN between January 2012 and March 2022. The development and validation datasets were temporally cut.

Engineering dual-mode near-infrared ratiometric thermometers based on rare earth-doped molybdates.

Near-infrared optical thermometers have sparked great interest for their ability to provide non-destructive testing and high-resolution. However, the restricted relative sensitivity and single temperature measurement mode represent the current limitations of luminescent thermometers. Herein, near-infrared dual-mode ratiometric thermometers with high sensitivity in La(MoO): Yb, Ln (LMO: YbLn, Ln = Er, Ho, Nd) phosphors were designed.

Correction: Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study.

[This corrects the article DOI: 10.1371/journal.pone.

Achieving Near-Infrared Highly Sensitive Temperature Sensing in Lanthanide-Doped Lead-Free Double Perovskite NaLaMgWO with Significant Thermal Enhancement.

The significant temperature response of lanthanide-doped up-conversion luminescent materials is typically characterized by a severe thermal quenching of the luminescence intensity at elevated ambient temperatures, which severely restricts materials' capability in temperature sensing. Herein, the influence of matrix phonon properties on the remarkable thermal enhancement effect in the thermosensitive material NaLaMgWO:Yb/Nd is reported. It is elucidated that achieving a significant thermal enhancement of Nd with a higher phonon energy oxide matrix is easier than a halide matrix, which has lower phonon energy by comparison with previous findings.

RNA Surveillance Factor SMG5 Is Essential for Mouse Embryonic Stem Cell Differentiation.

Nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional gene expression regulatory mechanism in eukaryotic cells. NMD eliminates aberrant mRNAs with premature termination codons to surveil transcriptome integrity. Furthermore, NMD fine-tunes gene expression by destabilizing RNAs with specific NMD features.

Toward Ultra-High Sensitivity Optical Thermometers and Bright Yellow LEDs Based on Phonon-Assisted Energy Transfer in Rare Earth-Doped LaZnTiO Double Perovskite.

Double perovskites, a class of ceramic oxides with unique crystal structures and diverse physical properties, show promise for various technological applications including solar cells, photodetectors, and light-emitting diodes (LEDs). Despite limited research on rare earth-doped double perovskites, leveraging their ultrahigh luminous efficiency to achieve bright yellow LED emission and addressing energy transfer challenges between Yb and Nd ions in double perovskite LaZnTiO with moderate phonon energy are explored in this work. Through phonon-assisted energy transfer, an ultrasensitive optical thermometer covering a wide temperature range is developed by utilizing the different temperature responses of Er emission in the visible light region and Nd emission in the near-infrared region based on the luminescence intensity ratio (LIR).

Endoscopic Combined Drainage of One Giant and Multiple Small Pancreatic Pseudocysts: A Case Report.

A pancreatic pseudocyst (PPC) is a frequent complication of pancreatitis, often stemming from alcohol, gallstones, or hyperlipidemia. Endoscopic treatment of PPC has become the mainstream treatment. A case of one giant and multiple small PPCs was observed, manifesting as repeated abdominal bloating, abdominal pain, nausea, and vomiting after meals.

Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study.

Background And Aims: Few studies have examined the relationship between daytime napping and risk of kidney diseases. We aimed to investigate the association of daytime napping with the incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). We also examined whether sleep duration modified the association of nap with CKD or ESKD.

Sensitive, Low-Background-Signal miRNA Analysis via the Self-Priming-Initiated Color Reaction Loaded on a Rolling Circle Amplification Product.

MicroRNAs (miRNAs) have been regarded as potential biomarkers in evaluating various diseases, such as pregnancy-induced hypertension and cancers. However, sensitive and reliable miRNA detection is still a challenge due to the low amplification efficiency and high background signal. Herein, we developed a colorimetric method for miRNA detection utilizing the self-priming-initiated color reaction loaded on a rolling circle amplification (RCA) product.

Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design.

The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at the Department of Neurology, Army Medical University Southwest Hospital in China (ChiCTR1900021405) from February 2019 to December 2019. Fifty-six participants with mild to moderate PD (Hoehn-Yahr stage 1-3) were randomly assigned to the FMT and placebo group, 27 patients in the FMT group and 27 in the placebo group completed the whole trial.

Cystatin C-based estimated glomerular filtration rate and risk of stroke in the general population: a prospective cohort study.

Background: Previous results on the association between the estimated glomerular filtration rate (eGFR) and stroke are mixed. Most studies derived the eGFR from serum creatinine, which is affected by non-kidney determinants and thus has possibly biased the association with stroke risk.

Methods: In this cohort study, we included 429 566 UK Biobank participants (94.

mTORC2 acts as a gatekeeper for mTORC1 deficiency-mediated impairments in ILC3 development.

Group 3 innate lymphoid cells (ILC3s) are mediators of intestinal immunity and barrier function. Recent studies have investigated the role of the mammalian target of rapamycin complex (mTOR) in ILC3s, whereas the mTORC1-related mechanisms and crosstalk between mTORC1 and mTORC2 involved in regulating ILC3 homeostasis remain unknown. In this study, we found that mTORC1 but not mTORC2 was critical in ILC3 development, IL-22 production, and ILC3-mediated intestinal homeostasis.

The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease.

Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, and enterobacterial interactions are expected to provide a new target for the treatment of IBD. We collected recent studies on the enterobacterial interactions among the host, enterobacteria, and their metabolite products and discuss potential therapeutic options. Intestinal flora interactions in IBD are affected in the reduced bacterial diversity, impact the immune system and are influenced by multiple factors such as host genetics and diet.

Development and validation of a deep learning-based approach to predict the Mayo endoscopic score of ulcerative colitis.

Background: The ulcerative colitis (UC) Mayo endoscopy score is a useful tool for evaluating the severity of UC in patients in clinical practice.

Objectives: We aimed to develop and validate a deep learning-based approach to automatically predict the Mayo endoscopic score using UC endoscopic images.

Design: A multicenter, diagnostic retrospective study.

Optimization of deliquescence-proof perovskite-like CsErF phosphor and dual-mode luminescent intensity ratio thermometry.

The susceptibility of Cs-based fluorides to deliquescence has led to the fact that lanthanide-doped Cs-based fluorides and their related applications have hardly been reported. Herein, the method to solve the deliquescence of CsErF and its excellent temperature measurement performance were discussed in this work. Initially, the soaking experiment of CsErF found that water had irreversible damage to the crystallinity of CsErF.

The role of Th17 cells in inflammatory bowel disease and the research progress.

Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important parts of intestinal immunity and regulators of Th17 cellular immunity. Th17 cell differentiation is regulated by intestinal bacteria and cytokines, and Th17 cells regulate the intestinal mucosal immune microenvironment by secreting cytokines, such as IL-17, IL-21, and IL-26.

Ice cream with sucralose, stevioside, and erythritol as sugar substitutes: Sensory profile and customer preference.

Sugar-free food has been gaining popularity because of low-calorie content. But sugar replacement by high-intensity sweeteners can negatively affect sensory. In this study, the effect of the addition of sucralose (Suc), stevioside (Ste), and erythritol (Ery) as sugar substitutes on the sensory profile and overall acceptance of ice cream were evaluated by penalty analysis (PA) based on the check-all-that apply (CATA) method, with those of the partial least squares (PLS) regression.

Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets.

Human pluripotent stem cell-derived islets (hPSC islets) are a promising alternative to primary human islets for the treatment of insulin-deficient diabetes. We previously demonstrated the feasibility of this approach in nonhuman primates; however, the therapeutic effects of hPSC islets can be limited by the maladaptive processes at the transplantation site. Here, we demonstrate successful implantation of hPSC-derived islets in a new transplantation site in the abdomen, the subanterior rectus sheath, in eight nonhuman primates (five male and three female).

PHF Technique: A Pyramid Hybrid Feature Fusion Framework for Severity Classification of Ulcerative Colitis Using Endoscopic Images.

Evaluating the severity of ulcerative colitis (UC) through the Mayo endoscopic subscore (MES) is crucial for understanding patient conditions and providing effective treatment. However, UC lesions present different characteristics in endoscopic images, exacerbating interclass similarities and intraclass differences in MES classification. In addition, inexperience and review fatigue in endoscopists introduces nontrivial challenges to the reliability and repeatability of MES evaluations.

A Method for Improving the Prediction of Outpatient Visits for Hospital Management: Bayesian Autoregressive Analysis.

The number of outpatient visits is generally influenced by various factors that are difficult to quantify and obtain, resulting in some irregular fluctuations. The traditional statistical methodology seldom considers these uncertainties. Accordingly, this paper presents a Bayesian autoregressive (AR) analysis to propose a forecasting framework to cope with the strict requirements.

Clinical study on sequential treatment of severe diarrhea irritable bowel syndrome with precision probiotic strains transplantation capsules, fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules.

Objective: To study the effect of precision probiotic strains transplantation capsules on diarrhea irritable bowel syndrome compared with fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules.

Methods: Two patients with severe irritable bowel syndrome were treated with precision probiotic strains transplantation capsules, fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules in sequence. IBS-SSS, IBS-QoL, GSRS, stool frequency, stool character, degree of abdominal pain, GAD-7, and PHQ9 scores of patients at 0, 2, 4, 6, 8, 10, and 12 weeks of treatment were monitored and recorded, and stool samples were collected for metagenomics and metabolomics.