[Association between the change regularity of peripheral blood mononuclear cell mitochondrial deoxyribonucleic acid content and human immunodeficiency virus-related lipodystrophy].

Objective: To investigate the change regularity of peripheral blood mononuclear cell (PBMC) mtDNA (mitochondrial deoxyribonucleic acid) content and its association with HIV-LD (human immunodeficiency virus-related lipodystrophy) in HAART (highly active antiretroviral therapy).

Methods: At baseline, Months 6 and 24 of therapy, the cryopreserved PBMC were collected from 33 patients on a regular follow-up at our clinic. Among them, 17 had HIV-LD.

Detection of HIV-1 viruses in tears of patients even under long-term HAART.

To determine whether HIV-1 viruses exist in tears of patients under HAART, a cross-sectional study was designed. All participants who underwent long-term HAART with undetectable plasma viral load had detectable HIV-1 viral load in tears (n = 16) and had no difference from the controls (n = 5). Our data suggested that the lacrimal gland and/or other tear-associated tissues could be new reservoirs for HIV-1 and precautions should be taken when doing eye examinations.

[Safety study of 52-week highly active antiretroviral therapy in 198 HIV/AIDS Chinese patients].

Objective: To evaluate the safety profiles of three nevirapine-based therapies for antiretroviral-naive Chinese adults infected with HIV-1 (human immunodeficiency virus-1).

Methods: For this prospective multicentric randomized trial, a total of 198 antiretroviral-naive HIV-1 positive patients were recruited from 13 research centers in China. They were randomly assigned to receive three NVP-based antiretroviral therapies for 52 weeks: Group A, AZT (zidovudine) + DDI (didanosine) + NVP (nevirapine); Group B, D4T (stavudine) + 3TC (lamivudine) + NVP; Group C, AZT + 3TC + NVP.

[The effect of exogenous glial cell line-derived neurotrophic factor on expression of gastric and colonic Akt, MAPK in slow transit constipation rats].

Objective: To study the expression of Akt and MAPK in the stomach and colon of slow transit constipation (STC) in rats, as well as the effect of exogenous glial cell line-derived neurotrophic factor (GDNF) on it.

Methods: Forty-four SD rats were divided into control group and model group randomly. The STC model group was established by gastric irrigation of rhubarb for 3.

Apparent diffusion coefficient of diffusion weighted MRI in endometrial carcinoma-Relationship with local invasiveness.

Objective: To evaluate the relationship between apparent diffusion coefficient (ADC) value and the local invasiveness of endometrial carcinoma.

Methods And Materials: The MR imaging of seventy-three patients with endometrial carcinoma proved by post-operative pathology and sixty-four patients with healthy uteri were retrospectively reviewed. All MR examinations included axial T2WI and T1WI, sagittal T2WI and diffusion-weighted sequences (b=0 and b=1000s/mm(2)).

Structural, electronic, and dynamical properties of methane under high pressure.

The electronic structure and lattice dynamical properties of solid methane under high pressure have been studied based on density functional theory. We identify a cubic structure with space group of I43m below 14 GPa, the Pmn2(1) structure in the range of 14-21 GPa, and the P2(1)/c structure from 21 to 65 GPa. Our obtained Raman spectra of the P2(1)/c structure agree well with the typical Raman active modes in the available experimental data.

[Survival analysis on 3103 HIV/AIDS patients receiving antiretroviral treatment in Dehong prefecture, Yunnan province].

Objective: To determine the survival rate of HIV/AIDS patients after receiving free antiretroviral treatment in Dehong prefecture, Yunnan province.

Methods: A retrospective cohort analysis was conducted on all the HIV/AIDS patients aged over 16 years who had started antiretroviral treatment during January 2007 throughout December 2009 in Dehong prefecture.

Results: A total of 3103 HIV/AIDS patients had received antiretroviral treatment during the study period.

[Proportions and correlates of recent HIV infections among newly reported HIV/AIDS cases from 2005 through 2009 in Dehong prefecture, Yunnan province].

Objective: To determine the proportions and correlates of recent HIV infections among newly reported HIV/AIDS cases from 2005 through 2009 in Dehong prefecture, Yunnan province.

Methods: All available serum samples of newly reported HIV/AIDS cases during 2005 - 2009 period in Dehong prefecture, were tested using the BED HIV incidence capture enzyme immunoassay (BED-CEIA).

Results: A total of 9367 HIV/AIDS cases were newly reported in 2005 through 2009, of whom 7252 (77.

[Incidence and risk factors of HIV infection among sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province].

Objective: To study the HIV incidence and risk factors among sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province.

Methods: A cohort of sero-negative spouses of the HIV patients had been developed and followed up since November, 2005. HIV new infections and related behaviors had been investigated every six months.

[The impact of highly active antiretroviral therapy on bone mineral density in human immunodeficiency virus infected patients].

Objective: To evaluate the influence of highly active antiretroviral therapy (HAART)on bone mineral density(BMD) of human immunodeficiency virus (HIV) infected patients and correlating clinical factors.

Methods: The clinical data from 2007 to 2008 were analyzed, including 50 patients treated with HAART (named treated group), 12 HIV-infected antiretroviral-naive patients (named untreated group) and 20 healthy people (named control group). Lumbar, femoral neck, femur, femoral greater trochanter and whole body BMD were measured by dual energy X-ray absorptiometry.

Dimensionality switching through a thermally induced reversible single-crystal-to-single-crystal phase transition in a cyanide complex.

The heterometallic hexanuclear cyanide-bridged complex {[Mn(bpym)(H(2)O)](2)[Fe(HB(pz)(3))(CN)(3)](4)} (1), its C(15)N and D(2)O enriched forms {[Mn(bpym)(H(2)O)](2)[Fe(HB(pz)(3))(C(15)N)(3)](4)} (2) and {[Mn(bpym)(D(2)O)](2)[Fe(HB(pz)(3))(CN)(3)](4)} (3), and the hexanuclear derivative complex {[Mn(bpym)(H(2)O)](2)[Fe(B(pz)(4))(CN)(3)](4)}·4H(2)O (4) [bpym = 2,2'-bipyrimidine, HB(pz)(3)(-) = hydrotris(1-pyrazolyl)borate, B(pz)(4)(-) = tetra(1-pyrazolyl)borate] have been synthesized. Their structures have been determined through single-crystal X-ray crystallography at different temperatures. Whereas 3 and 4 maintain a discrete hexanuclear motif during the entire temperature range investigated (down to 95 K), 1 and 2 exhibit a thermally induced reversible single-crystal to single-crystal phase transition driven by a remarkable concerted rearrangement of hydrogen and cyanide coordination bonds.

[Fe(II)LSCo(III)LS]2 ⇔ [Fe(III)LSCo(II)HS]2 photoinduced conversion in a cyanide-bridged heterobimetallic molecular square.

The self-assembly of [Fe(III){B(pz)(4)}(CN)(3)](-) and [Co(II)(bik)(2)(S)(2)](2+) affords the diamagnetic cyanide-bridged [Fe(II)(LS)Co(III)(LS)](2) molecular square which is converted into the corresponding magnetic [Fe(III)(LS)Co(II)(HS)](2) species under light irradiation at relatively low temperatures.

A new family of oxime-based hexanuclear manganese(III) single molecule magnets with high anisotropy energy barriers.

A magneto-structural study of two salicylamidoxime-based {Mn(6)} single-molecule magnets revealed that their anisotropy energy barriers, which can reach the current record for d-transition metal complexes, are strongly dependent upon the precise arrangement of ligands and the solvation state.

Impact of hepatitis C virus coinfection on HAART in HIV-infected individuals: multicentric observation cohort.

Objective: To evaluate the influence of hepatitis C virus (HCV) coinfection on clinical, immunological, and virological responses and on adverse reactions to nevirapine-containing highly active antiretroviral therapy (HAART) in Chinese adult antiretroviral-naive HIV-positive patients.

Methods: This prospective, multicentric study enrolled 175 HIV-1-positive subjects who initiated HAART and attended follow-up visits over 100 weeks from 2005 to 2007. They were grouped based on HCV antibody and HCV RNA test results.

One dimensional assembly of Mn₆ single molecule magnets linked by oligothiophene bridges.

A new 1D coordination polymer comprised of [Mn(III)(6)O(2)(Et-sao)(6)(EtOH)(4)(H(2)O)(2)](2+) units and bithiophene dicarboxylato was synthesized by mixing EtsaoH(2) (salicylaldoxime), H(2)btda (2,2'-bithiophene-5,5'-dicarboxylic acid) and Mn(ClO(4))(2)·6H(2)O in the presence of NEt(4)OH. The crystal structure was determined and consists of Mn(6) clusters bridged by the bithiophene dicarboxylato ligands coordinated to two of the Mn(III) ions of the Mn(6) polynuclear complex. Direct current magnetic measurements show an overall ferromagnetic interaction between the Mn(III) ions within the Mn(6) cluster leading to an S = 12 ground state for the Mn(6) unit.

[Effect of soy isoflavones on peri-menopausal symptom and estrogen].

Objective: To study the effect of soy isoflavones (SI) on improving peri-menopausal symptoms and the secretion of estrogen.

Methods: Fifty women accompany with peri-menopausal symptoms were single-blindly randomized into two groups, the SI group with a daily 120 mg/d of soy isoflavones for eight weeks and the control group with placebos. Serum 17 beta-estrodiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), progesterone, testosterone and prolactin (PRL) were assessed at baseline and after 8 weeks of observation.

[Tracing the sources of newly reported HIV infections in Dehong prefecture of Yunnan province].

Objective: To trace and provide HIV-testing among those having contacts with HIV-infected individuals at various levels in Dehong prefecture, Yunnan province and to evaluate the effectiveness and feasibility of such investigation as a supplemental strategy for HIV testing and control.

Methods: Newly reported HIV infections from August throughout October in Dehong prefecture, in 2008 were asked to provide contact information of persons whom they had high risk contacts with. Persons having had risk contacts with HIV-infected cases were here of interviewed and their blood tested on the sero-status of HIV.

Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China.

Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.

[A study on yearly and daily circadian rhythm of cardiovascular events].

Objective: To investigate the circadian and seasonal distribution of cardiovascular events (CVE) and the relationship between average monthly temperature and the incidence of CVE.

Methods: A total of 5837 emergency patients with CVE were enrolled from 1997 to 2007. The exact admission time of each patient was registered.

[The expression of glial cell line-derived neutrophil factor and its effect on colonic transit function in slow transit constipation rats].

Objective: To investigate the distribution and expression of glial cell line-derived neutrophil factor(GDNF)in colon of slow transit constipation (STC) rats and the effect of exogenous GDNF on colon transit.

Methods: Forty-eight SD rats were divided randomly into controlled group and model group. The models were established by gastric irrigation of rhubarb for 3.

Impact of baseline CD4(+) T cell counts on the efficacy of nevirapine-based highly active antiretroviral therapy in Chinese HIV/AIDS patients: a prospective, multicentric study.

Background: CD4(+) T cell counts have been used as the indicator of human immunodeficiency virus type 1 (HIV-1) disease progression and thereby to determine when to start highly active antiretroviral therapy (HAART). Whether and how the baseline CD4(+) T cell count affects the immunological and viral responses or adverse reactions to nevirapine (NVP)-containing HAART in Chinese HIV-1 infected adults remain to be characterized.

Methods: One hundred and ninety-eight HIV-seropositive antiretroviral therapy (ART)-naive subjects were enrolled into a prospective study from 2005 to 2007.

Recent research in selective cyclin-dependent kinase 4 inhibitors for anti-cancer treatment.

It is well known that cyclins and cyclin-dependent kinases (CDKs) play essential roles in regulation of the cell cycle. In past two decades, the scientific researches suggest that the cyclin D1/ CDK4 complex is a key regulator of the transition through the G1 phase of the cell cycle. Moreover, deregulation of the cyclin D /CDK4 pathway has been identified in multiple tumor types.

Macroscopic single-crystal tubes assembled with porous supramolecular architecture of water-soluble calixarene and phenanthroline.

Single-crystal tubular products on the millimetre scale have been synthesized from water-soluble calixarene and phenanthroline in the presence of lanthanides by a hydrothermal method, in which the extended structures contain some 1D infinite channels.

Three generic nevirapine-based antiretroviral treatments in Chinese HIV/AIDS patients: multicentric observation cohort.

Background: The purpose of this study was to evaluate the efficacy and safety of three nevirapine-based antiretroviral treatments for adult antiretroviral-naïve Chinese patients with HIV-1 infection.

Methodology: This was a prospective, multicenter study. 198 antiretroviral-naïve HIV-1 positive subjects with CD4 lymphocyte counts between 100/ul and 350/ul and plasma HIV-1 RNA levels more than 500 copies/ml were randomized to start three NVP-based antiretroviral treatments: group A, NVP+AZT+ddI; group B, NVP+3TC+d4T; group C, NVP+AZT+3TC.

Gamma-ray up-regulated holocarboxylase synthetase gene.

Purpose: To investigate the effects of holocarboxylase synthetase (HCS) gene to irradiation in a time- and dose-dependent manner.

Materials And Methods: AHH-1 cells, Hela cells, and the nude mice inoculated with tumor cells were exposed to gamma-ray of cobalt 60. The mRNA level of HCS was detected using real-time PCR.