Publications by authors named "YanLi Cao"

Background And Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide disease with a broad spectrum of symptoms. Though mild in early stages, further development of MASLD causes steatohepatitis, cirrhosis, liver cancers, and accompanied diabetes. Discovery of the critical regulators in MASLD progression hold great values in both basic and translational medicine.

View Article and Find Full Text PDF

Background: Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis and is currently lacking specific pharmacological treatments, highlighting the critical need for therapeutic development. Icariin (ICA), a prenylated flavonol glycoside, was previously found to exhibit several pharmacological effects, but its potential to combat CVB3 remains uninvestigated.

Purpose: This study aimed to elucidate the anti-CVB3 efficacy of ICA and elucidate its molecular mechanisms.

View Article and Find Full Text PDF
Article Synopsis
  • Coxsackievirus group B3 (CVB3) is a major cause of viral myocarditis (VMC), and current treatments are lacking; this study reveals how CVB3 inhibits a key enzyme, argininosuccinate synthase 1 (ASS1), impacting the immune response and inflammation in the heart.* -
  • The research demonstrates that CVB3 not only manipulates metabolic pathways by consuming citrulline to enhance ASS1 but also actively promotes inflammatory responses through macrophage activation, contributing to VMC progression.* -
  • Supplementing with citrulline can counteract these effects by reducing ASS1 levels, improving macrophage polarization, and reducing the harmful impacts of CVB3,
View Article and Find Full Text PDF

Frequent viral infections leading to infectious disease outbreaks have become a significant global health concern. Fully elucidating the molecular mechanisms of the immune response against viral infections is crucial for epidemic prevention and control. The innate immune response, the host's primary defense against viral infection, plays a pivotal role and has become a breakthrough in research mechanisms.

View Article and Find Full Text PDF
Article Synopsis
  • The text discusses the link between globally prevalent infections and chronic gastritis, potentially leading to gastric cancer, prompting the need for improved vaccine strategies due to rising antibiotic resistance.
  • Researchers explored using outer membrane vesicles (OMVs) from a specific bacterial strain as a platform to deliver multiple antigens, unlike current single-antigen vaccines.
  • The study engineered three key antigens and found that co-delivering specific combinations significantly enhanced immune responses in mice, suggesting OMVs as a promising vector for developing more effective vaccines against these infections.
View Article and Find Full Text PDF

Background: Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent glocal cause of chronic hepatic disease, with incidence rates that continue to rise steadily. Treatment options for affected patients are currently limited to dietary changes and exercise interventions, with no drugs having been licensed for the treatment of this disease. There is thus a pressing need for the development of novel therapeutic strategies.

View Article and Find Full Text PDF

Recent studies have explored the association between primary aldosteronism and cardiovascular disease incidence. The association between specific primary aldosteronism treatments and differential improvement in cardiovascular event rates is yet to be established. This study was designed to compare the relative effects of spironolactone therapy and surgical intervention on cardiovascular outcomes among primary aldosteronism patients.

View Article and Find Full Text PDF

Background: Observational studies have reported associations between Barrett's esophagus (BE) and obstructive sleep apnea syndrome (OSAS), but the causal relationship remained unclear due to potential confounding biases. Our study aimed to elucidate this causal relationship by deploying a two-sample Mendelian randomization (MR) methodology.

Methods: Instrumental variables (IVs) for Barrett's esophagus were obtained from a public database that comprised 13,358 cases and 43,071 controls.

View Article and Find Full Text PDF

Carbon quantum dots-based memristors (CQDMs) have emerged as a rising star in data storage and computing. The key constraint to their commercialization is memristance variability, which mainly arises from the disordered conductive paths. Doping methodology can optimize electron and ion transport to help construct a stable conductive mode.

View Article and Find Full Text PDF

Aims: The aim was to describe the diabetes regional burden, trends, and inequalities in the Western Pacific region.

Methods: The Global Burden of Disease 2019 study was used to evaluate the prevalence, incidence, mortality, disability-adjusted life year (DALY) rates and average annual percentage changes (AAPCs) in diabetes in the Western Pacific region from 1990 to 2019. Cross-country inequalities in the DALY rates of diabetes were estimated between 1990 and 2019.

View Article and Find Full Text PDF

Hemophagocytic lymphohistiocytosis (HLH) is a rare histiocytic disorder characterized by reactive hyperplasia of the mononuclear phagocytic system, which is primarily caused by dysfunction of cytotoxic killer cells and natural killer cells, leading to antigen clearance barriers and the overactivation of the mononuclear phagocytic system due to continuous antigen stimulation. HLH encompasses a group of clinical syndromes marked by the overproduction of inflammatory cytokines. A 68-year-old Chinese man presented with persistent fever, chills, nausea, and vomiting; the patient had no history of any underlying conditions.

View Article and Find Full Text PDF
Article Synopsis
  • Coxsackievirus A10 (CA10) is linked to hand, foot, and mouth disease (HFMD), and this study analyzed its molecular epidemiology in Zhejiang Province between 2017 and 2022.
  • The research showed that most HFMD cases occurred in children under 3, with a peak in June, and identified an increase in CA10 cases possibly due to the use of EV71 vaccines.
  • The study isolated 90 CA10 strains, finding them grouped in two genogroups, indicating the need for improved surveillance and ongoing research for effective HFMD prevention.
View Article and Find Full Text PDF

The impact of air pollution is one of the hotspots attracting continuous scholarly attention, but the comprehensive statistical and visual analysis reviews are few. Employing the method of bibliometric analysis, this paper took the relevant literature from 1996 to April 2022 on the Web of Science as the research object. Through the methods of keyword co-occurrence analysis and burst analysis, the spatiotemporal evolution trend, cooperation network, outstanding scholars, knowledge base, and research focus of air pollution impact research are visually presented.

View Article and Find Full Text PDF

Background: is a commensal yeast that may cause life-threatening infections. Studies have shown that the cytochrome b-c1 complex subunit 7 gene () of encodes a protein that forms a component of the mitochondrial electron transport chain complex III, making it an important target for studying the virulence of this yeast. However, to the best of our knowledge, the functions of have not yet been characterized.

View Article and Find Full Text PDF

It is recognized that the cerebral ischemia/reperfusion (I/R) injury triggers inflammatory activation of microglia and supports microglia-driven neuronal damage. Our previous studies have shown that ginsenoside Rg1 had a significant protective effect on focal cerebral I/R injury in middle cerebral artery occlusion (MCAO) rats. However, the mechanism still needs further clarification.

View Article and Find Full Text PDF

Desert ecosystem CO exchange may play an important role in global carbon cycling. However, it is still not clear how the CO fluxes of shrub-dominated desert ecosystems respond to precipitation changes. We performed a 10-year long-term rain addition experiment in a desert ecosystem in northwestern China.

View Article and Find Full Text PDF

Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features, which are caused by mutations in the thyroid hormone receptor beta () gene. Recent studies have indicated a close association between mutations and human cancers, but the mechanistic role of mutations in carcinogenesis is unknown. Herein, we report two cases of RTHβ coexisting with papillary thyroid carcinoma (PTC) and their follow-up results.

View Article and Find Full Text PDF

Galangin, a naturally available flavonoid, induces a variety of pharmacological activities and biological effects via several mechanisms. However, in vivo metabolism of galangin has not been fully explored, which means knowledge of its pharmacodynamics and application potential is limited. The objective of this study was to establish an ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method for the rapid profiling and identification of galangin metabolites in vitro and in vivo using unique online information-dependent acquisition with multiple mass defect filtering combined with dynamic background subtraction in positive ion mode.

View Article and Find Full Text PDF
Article Synopsis
  • Hand-foot-mouth disease (HFMD), primarily affecting children, is caused by various enteroviruses and displays seasonal variations in incidence, potentially influenced by meteorological factors.
  • A study analyzed HFMD cases in Zhejiang province from 2010 to 2018, linking them to daily weather data to explore how specific serotypes relate to temperature and humidity.
  • Findings revealed increasing overall HFMD cases despite fewer severe outcomes, with temperature and humidity exhibiting specific risk patterns for major serotypes (CVA16 and EV71) at certain thresholds, suggesting a complex interaction between weather conditions and disease incidence.
View Article and Find Full Text PDF

Background: Hierarchical diagnosis and treatment has been gradually implemented throughout the China. Primary physicians are the main force in primary-level medical and health services, which means that standardized training of primary-level doctors is indispensable.

Objectives: Evaluation of the effect of primary physician training on standardized management of diabetes, and comparison of the effects of different training models.

View Article and Find Full Text PDF
Article Synopsis
  • An opportunistic pathogen affecting both animals and humans has been found in foxes, raccoons, and minks in China, with unclear infection characteristics.
  • Analysis revealed high antibiotic resistance, with over 90% of isolates resistant to florfenicol and significant multi-drug resistance noted.
  • Virulence genes were present in all isolates, indicating varying lethal abilities, and similarities were observed in resistance profiles between animal isolates and environmental samples.
View Article and Find Full Text PDF

The saprophytic filamentous fungus Trichoderma reesei represents one of the most prolific cellulase producers isolated from nature. also produces a typical yellow pigment identified as sorbicillinoids during cultivation. Here, we identified an evolutionarily conserved histone remodeling factor, ISW1, in that simultaneously participates in regulating cellulase and the yellow pigment biosynthesis.

View Article and Find Full Text PDF

Introduction: Diabetes and population aging have become public health issues of global concern. The secular incidence trends and the impact of population aging on mortality due to type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in China remain unclear.

Research Design And Methods: The incidence and mortality rates of T1DM and T2DM from 1990 to 2019 were abstracted from the Global Burden of Disease Study (GBD) 2019 database.

View Article and Find Full Text PDF
Article Synopsis
  • Plant phenology is highly responsive to climate change, particularly in arid regions like northwest China, where future climate models predict more intense and unpredictable rainfall patterns.
  • A recent study showed that increased precipitation led to earlier leaf budding and unfolding in spring, while the duration of these phases varied depending on whether the year was extremely dry or wet.
  • The study aimed to understand how these changes in precipitation influence the timing and duration of leaf senescence and fall, revealing that both the start and end times of these events advanced with enhanced rainfall, especially in wet conditions.
View Article and Find Full Text PDF

Background: Myocardial ischemia (MI) often causes angina, arrhythmia, and cardiac insufficiency, sometimes resulting in death. Ischemia-induced myocardial tissue damage is attributed to the hypoxic damage of myocardial cells producing apoptosis and decreased proliferation. Taurine has been shown to improve MI, but its mechanism is largely unknown.

View Article and Find Full Text PDF