Expression profile analysis of LncRNAs and mRNAs in pre-receptive endometrium of women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer.

Background: To compare the expression levels of long non-coding RNA (lncRNA) and messenger RNA (mRNA) in pre-receptive endometrium between patients with Polycystic Ovary Syndrome (PCOS)and normal ovulation undergoing in vitro fertilization-embryo transfer (IVF-ET).

Methods: Endometrial tissues were collected with endometrial vacuum curette in pre-receptive phase (3 days after oocytes retrieval) from PCOS and control groups. LncRNAs and mRNAs of endometrium were identified via RNA sequencing and alignments.

Aloe vera for prevention of radiation-induced dermatitis: A systematic review and cumulative analysis of randomized controlled trials.

Aloe vera were frequently reported to reduce the risk of radiation-induced dermatitis (RID), but the quantitative results from all the relevant studies were not presently available. This study sought to conduct a cumulative analysis to better clarify the preventive effects of aloe vera in RID. MEDLINE (PubMed), Cochrane, EMBASE, PsychINFO, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang Database were utilized for identifying the eligible randomized controlled trials (RCTs) without language restrictions, up to March 2022.

Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium.

Background: Neuroimaging studies on major depressive disorder (MDD) have identified an extensive range of brain structural abnormalities, but the exact neural mechanisms associated with MDD remain elusive. Most previous studies were performed with voxel- or surface-based morphometry which were univariate methods without considering spatial information across voxels/vertices.

Methods: Brain morphology was investigated using voxel-based morphometry (VBM) and source-based morphometry (SBM) in 1082 MDD patients and 990 healthy controls (HCs) from the REST-meta-MDD Consortium.

Identification of Genetic Predisposition in Noncirrhotic Portal Hypertension Patients With Multiple Renal Cysts by Integrated Analysis of Whole-Genome and Single-Cell RNA Sequencing.

The multiple renal cysts (MRC) occur in some patients with noncirrhotic portal hypertension (NCPH) could be a subset of ciliopathy. However, the potential genetic influencers and/or determinants in NCPH with MRC are largely unknown. The aim of this study was to explore the potential candidate variants/genes associated with those patients.

fMRI evidence reveals emotional biases in bilingual decision making.

Research indicates that the foreign language effect on decision making can be partially explained by a reduction in emotional response in the second language. In this fMRI study, we aimed at elucidating the neural mechanisms underpinning the interaction between language and emotion in decision making. Across multiple trials, Chinese-English bilinguals were asked to decide whether to gamble in a Gambling task, and received feedbacks either in L1 (Chinese) or in L2 (English).

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer.

Background: Distant metastasis is the major cause of mortality in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy. Local radiotherapy can trigger an abscopal response to metastatic tumor cells. However, the abscopal effect is a rare event.

Porous and flexible membrane derived from ZIF-8-decorated hyphae for outstanding adsorption of Pb ion.

Metal-organic frameworks (MOFs) based membranes with superior mechanical properties are of particular interest in purification, separation, and catalysis. Nevertheless, their fabrication still remains a grand challenge. Here, fungus hyphae (Mucor) were used as a robust scaffold to load the MOFs and induced the formation of porous and flexible membranes.

Resident risk attitude analysis in the decision-making management of waste incineration construction.

Environmental pollutants generated by waste incineration plants, such as heavy metals and dioxin, make surrounding residents very sensitive to the construction of such facilities. This sensitivity and anxiety of residents may induce group events, which further leads to the emergence of social risks. Based on risk perception theory, a total of 320 questionnaires was designed and handed out to residents neighboring to Jiangqiao Waste Incineration Plant in Shanghai, China to detect the factors affecting risk attitude toward such plants.

Effects of Pulsatile Cupping on Body Pain and Quality of Life in People with Suboptimal Health:A Randomized Controlled Exploratory Trial.

The curative effect of pneumatic pulsatile cupping on pain has been shown. This study was conducted to investigate effects of the pulsating frequency of pneumatic pulsatile cupping, compared with traditional cupping (TC), on body pain and quality of life (QoL) in people with suboptimal health status (SHS). Ninety-six participants with SHS were randomized to low-frequency (LF;  = 24) or high-frequency (HF;  = 24) pulsating cupping, traditional cupping (TC;  = 24), or wait-list (WL;  = 24) groups.

Is the finer the better for municipal solid waste (MSW) classification in view of recyclable constituents? A comprehensive social, economic and environmental analysis.

With the accelerating pace of urbanization, the continuous increase of municipal solid waste (MSW) has become a major obstacle to China's economic development. Therefore, China recently regards MSW classification scenario as an important strategy for national ecological civilization. However, published references have not focused on MSW classification in view of environmental, economic and social acceptation simultaneously.

Original endomorphin-1 analogues exhibit good analgesic effects with minimal implications for human sperm motility.

To search a novel analgesic characterizes the effects on human sperm motility as minimal as possible. A new class of endomorphin-1 (EM-1) analogues was synthesized by combining successful chemical modifications including N-terminal guanidino modification, Phe was chlorinated, replaced of l-Pro-Trp by d-Ala-Gly or d-Pro-Gly at position 2 and 3. Their bioactivities were measured by radioligand binding assay, metabolic stability, antinociception activity and sperm motility effects.

Original endomorphin-1 analogues exhibit good analgesic effects.

A new class of endomorphin-1 analogues was synthesized by combining successful chemical modifications including N-terminal guanidino modification, Phe was chlorinated, D-Ala-Gly Substituted L-Pro. Their bioactivities were measured by radioligand binding assay, metabolic stability and the tail-flick test. In radioligand binding assays, analogue GAGPC (N-Amidino-Tyr-D-Ala-Gly-Trp-p-Cl-Phe-NH), shown a μ-opioid receptor affinity about 1.

Improving proactive control with training on language switching in bilinguals.

The present study examined how a short period of language switching training affects nonverbal cognitive control, as measured by the AX version of the Continuous Performance Test. A group of Chinese-English bilinguals were trained over 10 days on a picture naming task that required switching between languages. We recorded their behavioral performance and event-related potentials before and after the training to examine its effects on cognitive performance.

Up-regulation of microRNA-145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells.

Background: MicroRNA-145 (miR-145) has been reported to be a tumor-suppressing agent in several studies. It can repress pluripotency and control human embryonic stem cell differentiation by regulating the core pluripotency factor OCT4. However, it is not known whether miR-145 can play a role in inducing tumor cell differentiation and repressing growth of tumors.

Resting energy expenditure and glucose, protein and fat oxidation in severe chronic virus hepatitis B patients.

Aim: To study and determine the resting energy expenditure (REE) and oxidation rates of glucose, fat and protein in severe chronic hepatitis B patients.

Methods: A total of 100 patients with liver diseases were categorized into three groups: 16 in the acute hepatitis group, 56 in the severe chronic hepatitis group, and 28 in the cirrhosis group. The REE and the oxidation rates of glucose, fat and protein were assessed by indirect heat measurement using the CCM-D nutritive metabolic investigation system.

Binding of progesterone to cell surfaces of human granulosa-lutein cells.

Progesterone is produced by granulosa cells under the influence of luteinizing hormone. Nuclear progesterone receptors have been found in rat granulosa cells. Human granulosa-lutein cells rapidly respond to progesterone with an increase in intracellular calcium suggesting the existence of a nongenomic mechanism.

Rapid effects of pesticides on human granulosa-lutein cells.

Following our previous demonstration that p,p'-DDE (dichlorodiphenylchloroethylene), at environmentally relevant concentrations, can rapidly increase intracellular calcium [Ca2+]i concentrations in human granulosa-lutein cells, we examined whether other pesticides, such as Kepone, o,p-DDE and methoxychlor, have similar effects. Cultured human granulosa-lutein cells were loaded with Fura-2 AM, and changes in [Ca2+]i concentrations within small areas of single cells were studied with a dynamic digital Ca2+ imaging system. Kepone, at concentrations of 0.

Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells.

Persistent metabolites of pesticides such as p,p'-DDE, at environmentally relevant concentrations, have been shown to have a rapid effect on intracellular calcium [Ca2+]i concentrations in human granulosa-lutein cells. Since endocrine disrupting substances can be transferred from the maternal circulation to the fetus the present study examined whether the pesticides, kepone, o,p-DDE, p,p'-DDE and methoxychlor, could alter cytoplasmic calcium [Ca2+]cyt concentrations in human umbilical vein endothelial (HUVE) cells. Cultured HUVE cells were loaded with Fura-2 AM and changes in [Ca2+]cyt of single cells were studied using a dynamic digital Ca2+ imaging system.