Mechanism of antibacterial action of oxymatrine from . against , a zoonotic pathogen.

In the severe situation of the abuse of antibiotics and the continuous emergence of drug-resistant strains, searching for new antibacterial agents is an urgent need. In this study, after exposing to oxymatrine which is non-toxic, no residue and easily soluble in water, its antibacterial ability and action mechanism were investigated. The results showed oxymatrine had antibacterial property against the tested strains, and it changed the completeness of bacterial cytomembrane and cell wall, induced apoptosis in bacterial cells, blocked the process of cell cycle and suppressed bacterial DNA and protein biosynthesis, suggesting it was a promising antibacterial agent for the prophylaxis and therapy of human and animal diseases resulted from .

Suppressing Thermal Conductivity in SrTiO by Introducing Oxygen Isotope Disorder.

Transition metal oxides are promising candidates in the field of thermoelectricity, which can convert heat and electricity into each other and realize the efficient utilization of waste energy. For the figure of merit = σ/(κ + κ), a lower thermal conductivity is desired for an enhanced , and cation doping is an appropriate way to regulate the thermal transport properties. However, because , σ, and κ are strongly coupled with each other, cation doping for one parameter modification can generate compensation with others, making regulation more difficult.

Acoustic vector sensor based multi-sources localization in reverberant environment using acoustic polarization state analysis.

Estimating the direction of arrival (DOA) under real-world conditions poses a significant challenge, as reverberations can lead to erroneous information. We note that the direct-path component and the reverberant components of sound exhibit distinct polarization states within the acoustic particle velocity field. Based on this observation, we propose and experimentally verify a method for localizing multiple sources in reverberant environments using a single acoustic vector sensor (AVS).

OncomiR mdv1-miR-M7-5p promotes avian lymphomatosis by modulating the BCL2/Bax mitochondrial apoptosis signaling pathway.

Marek's disease virus (MDV) is an oncogenic alphaherpesvirus that infects poultry and causes fatal lymphomas in infected chickens. Notably, the mdv1-miR-M7-5p, a pivotal oncomiR encoded by MDV, is closely associated with viral replication and latency. Here, mdv1-miR-M7-5p was transfected into the chicken lymphoma cell line MSB1, which resulted in the inhibition of lymphoma cell apoptosis and an increase in lymphoma cell proliferation and migration.

Gigahertz Surface Acoustic Wave Topological Rainbow in Nanoscale Phononic Crystals.

Precisely engineered gigahertz surface acoustic wave (SAW) trapping enables diverse and controllable interconnections with various quantum systems, which are crucial to unlocking the full potential of phonons. The topological rainbow based on synthetic dimension presents a promising avenue for facile and precise localization of SAWs. In this study, we successfully developed a monolithic gigahertz SAW topological rainbow by utilizing a nanoscale translational deformation as a synthetic dimension.

Adhesive-Free, Light, and Strong Particle Board.

Wood particle boards are massively used in construction and household products. But they often raise health and environmental concerns because of the formaldehyde-based adhesives. More sustainable and high-strength particle boards are developed on a bio-based materials or their derivatives.

Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry.

Background: To investigate the impact of the number of positive lymph nodes (PLNs) on long-term survival and pathological nodal stage in patients with oral tongue squamous cell carcinoma (OTSCC).

Materials And Methods: Newly diagnosed and nonmetastatic adult patients with OTSCC who underwent curative resection were identified between January 2010 and December 2020. External validation was performed via the SEER registry.

Topological Phononic Fiber of Second Spin-Chern Number.

The discovery of quantum spin Hall effect characterized by the first spin-Chern numbers in 2D systems has significantly advanced topological materials. To explore its 4D counterpart is of fundamental importance, but so far remains elusive in experiments. Here, we realize a topological phononic fiber protected by the second spin-Chern number in a 4D manifold, using a 3D geometric structure combined with a 1D rotational parameter space.

Evidence for Intermittent Theta Burst Transcranial Magnetic Stimulation for Dysphagia after Stroke: A Systematic Review and Meta-analysis.

Dysphagia is the most common serious complication after stroke, with an incidence of about 37-78%, which seriously affects the independence of patients in daily life and clinical recovery. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neuromodulation technique, is an emerging option for post-stroke dysphagia. Theta burst stimulation (TBS) is a new mode of transcranial magnetic stimulation that simulates the frequency of pulses released in the hippocampus.

The Crystallization Regulation Effect of the Phenyl Ring of Passivators for Blue Perovskite Light-Emitting Diodes.

Although metal halide perovskites (MHPs) have demonstrated remarkable external quantum efficiencies (EQEs) in red and green light-emitting diodes (LEDs), the blue ones confront efficiency and stability problems due to the high defect density in the perovskite films. Large amounts of defect passivation strategies are successfully developed to improve the device performance. Nevertheless, the influence of the molecular configuration of the passivators on the perovskite crystallization process has not been comprehensively investigated so far.

The efficacy and safety of combined therapy with endobronchial tamponade and bronchial artery embolization for massive hemoptysis.

Background: Massive hemoptysis is characterized by its life-threatening nature, potentially leading to airway obstruction and asphyxia. The objective of this study was to evaluate the clinical effectiveness of combining endobronchial tamponade with bronchial artery embolization (BAE) in the treatment of massive hemoptysis.

Methods: Between March 2018 and March 2022, a total of 67 patients with massive hemoptysis who underwent BAE were divided into two groups: the combination group (n = 26) and the BAE group (n = 41).

Obesity enhances the response to neoadjuvant anti-PD1 therapy in oral tongue squamous cell carcinoma.

Objectives: Previous studies have demonstrated that obesity may impact the efficacy of anti-PD1 therapy, but the underlying mechanism remains unclear. In this study, our objective was to determine the prognostic value of obesity in patients with oral tongue squamous cell carcinoma (OTSCC) treated with pembrolizumab and establish a subtype based on fatty acid metabolism-related genes (FAMRGs) for immunotherapy.

Materials And Methods: We enrolled a total of 56 patients with OTSCC who underwent neoadjuvant anti-PD1 therapy.

Dion-Jacobson-Phase 2D Sn-Based Perovskite Comprising a High Dipole Moment of π-Conjugated Short-Chain Organic Spacers for High-Performance Solar Cell Applications.

The stability issue of Sn-based perovskite solar cells (PSCs) is expected to be resolved by involving a two-dimensional (2D) layered structure. However, Sn-based 2D PSCs, especially Dion-Jacobson (DJ)-phase ones with potentially good stability, have rarely been reported. Herein, superior DJ-phase Sn 2D perovskites with 3-aminobenzylamine (3ABA) or 4-aminobenzylamine (4ABA) π-conjugated short-chain ligands are reported to fabricate efficient 2D lead-free PSCs.

Integrative Management of Chemotherapy-Related Fatigue in Lung Cancer Patients with the Traditional Chinese Medicine Guiqi Erxian.

Objective: To observe the efficacy of Guiqi Erxian granule on chemotherapy-related fatigue in patients with lung cancer treated with chemotherapy.

Methods: A total of 76 lung cancer patients with chemotherapy-related fatigue as the main symptom from January 2017 to May 2018 were enrolled and randomly divided into a control group and a treatment group, n = 38/group. The patients in the control group received chemotherapy and basic treatment.

Mapping of Long-Wavelength Phonon Contribution in the Thermal Transport of Alloyed Semiconductor Superlattices.

The mapping of long-wavelength phonons is important to understand and manipulate the thermal transport in multilayered structures, but it remains a long-standing challenge due to the collective behaviors of phonons. In this study, an experimental demonstration of mapping the long-wavelength phonons in an alloyed AlGaAs/AlGaAs superlattice system is reported. Multiple strategies to filter out the short- to mid-wavelength phonons are used.

Gradual pollen presentation in 'Bluecrop': an adaptive mechanism to improve pollination efficiency and outcrossing.

Gradual pollen presentation is a plant reproductive mechanism to improve pollination efficiency and accuracy and promote outcrossing. 'Bluecrop' has a typical gradual pollen presentation mechanism. 'Bluecrop' exhibits an inverted bell-shaped flower with a white coloration.

Parameter design and effectiveness evaluation of wide strip mining of extra thick coal seams under dense buildings.

In order to safeguard the surface structures from mining damage while optimizing the liberation of coal resources under the dense surface buildings of the Cedi River coal mine. Considering that the analysis of the structure and type of surface buildings and the geological mining conditions of the mine, a wide strip mining design with a retention width of 70 m and a mining width of 50 m was finally determined by using the pressure arch theory and Wilson's theory, combined with the actual layout of working faces 51,002, 51,004 and 51,006 at the site.The strip mining design is verified by probability integral method and FLAC numerical simulation calculation respectively, The findings indicate that the highest value of earth surface subsidence created by the mining of the wide strip is 210 mm, the surface horizontal deformation value is 1.

Z-Type Ligand Enables Efficient and Stable Deep-Blue Perovskite Light-Emitting Diodes.

During the synthesis of deep-blue perovskite quantum dots (PQDs), they generally emerge as a two-dimensional byproduct with poor yield and low photoluminescence quantum yield (PLQY) due to amine ligand enrichment-induced abundant surface defects. Herein, we provide a colloidal synthesis method to prepare deep-blue CsPbBr PQDs in a green nontoxic solvent via strategic Z-type ligand engineering. Z-type ligands of zinc octanoate enable the formation of robust coordination bonds with surface bromide ions of PQDs, maintaining acid-base equilibrium and reducing excess amine enrichment on the PQDs surface.

Consumption of toxic benthic cyanobacteria by two common demersal fish: Growth, antioxidant and liver histopathology responses.

Benthic freshwater cyanobacteria have the potential to produce toxins. Compared with more extensively studied plankton species, little is known about the impact of harmful benthic cyanobacteria on aquatic organisms. As demersal fish are usually in direct contact with benthic cyanobacteria, it is important to understand their interactive effects.