Publications by authors named "Yan-zhong Wang"
In an effort to develop the biomimetic chemistry of [FeFe]‑hydrogenases for catalytic hydrogen evolution reaction (HER) in aqueous environment, we herein report the integrations of diiron dithiolate complexes into carbon nanotubes (CNTs) through three different strategies and compare the electrochemical HER performances of the as-resulted 2Fe2S/CNT hybrids in neutral aqueous medium. That is, three new diiron dithiolate complexes [{(μ-SCH)N(CHCHC(O)R)}Fe(CO)] (R = N-oxylphthalimide (1), NHCHpyrene (2), and NHCHPh (3)) were prepared and could be further grafted covalently to CNTs via an amide bond (this 2Fe2S/CNT hybrid is labeled as H1) as well as immobilized noncovalently to CNTs via π-π stacking interaction (H2) or via simple physisorption (H3). Meanwhile, the molecular structures of 1-3 are determined by elemental analysis and spectroscopic as well as crystallographic techniques, whereas the structures and morphologies of H1-H3 are characterized by various spectroscopies and scanning electronic microscopy.
View Article and Find Full Text PDFBackground: CA 19-9 is one of the most frequently used biomarkers for tumors.
Methods: We analyzed the influential factors of the Carbohydrate Antigen 19-9 (CA 19-9) levels in Chinese general population to better interpret the results of the CA 19-9 screening tests. 36,924 apparently healthy individuals and 1,335 patients with gastrointestinal (GI) tumors were involved in this study.
Article Synopsis
- The exact causes of meningiomas remain unclear, but there is evidence linking certain folate metabolism gene polymorphisms to various cancers.
- A study involving 600 meningioma patients and 600 controls analyzed specific gene variants (MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G) to explore their relationship with meningioma risk.
- Results indicated that the MTHFR 677 TT genotype was less frequent in meningioma patients, while the MTRR 66 GG variant showed a significant association with increased risk, suggesting these gene variants may influence meningioma risk in the Chinese Han population.
[Effect of siRNA for mutant p53 gene on biological behavior of gastric cancer cell line SGC7901].
Zhejiang Da Xue Xue Bao Yi Xue Ban
May 2012
Objective: To investigate the effects of silencing the expression of mutant p53 gene with RNA interference technique on biological behavior of gastric cancer SGC7901 cells.
Methods: Recombinant plasmid of mutant p53 gene-targeting siRNA was transfected into gastric cancer SGC7901 cells by Lipofectamine(TM)2000. The expressions of mutant p53 gene mRNA and protein were identified by RT-PCR and Western blot assay.