Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units.

Management of vancomycin administration for intensive care units (ICU) patients remains a challenge. The aim of this study was to describe a population pharmacokinetic model of vancomycin for optimizing the dose regimen for ICU patients. We prospectively enrolled 466 vancomycin-treated patients hospitalized in the ICU, collected trough or approach peak blood samples of vancomycin and recorded corresponding clinical information from July 2015 to December 2017 at Tai Zhou Hospital of Zhejiang Province.

Short- and long-term outcomes of laparoscopic versus open surgery for rectal cancer: A systematic review and meta-analysis of randomized controlled trials.

Objectives: The present meta-analysis aimed to evaluate the short- and long-term outcomes of laparoscopic surgery (LS) versus open surgery (OS) for rectal cancer.

Methods: PubMed, Web of Science, and Cochrane Library, were searched for eligible randomized controlled trials (RCTs) published up to June 2017. Operation related index, postoperative complication, and long-term survival rate and disease-free survival rate were evaluated by meta-analytical techniques.

Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts.

Background And Purpose: Icariin is a potent stimulator of osteogenic differentiation; however, the mechanism underlying its osteogenic effect remains unclear. The osteogenic effect of icariin is related to the upstream glucocorticoid-induced leucine zipper (GILZ) signaling pathway, and antagonism with dexamethasone-induced osteoblast inhibition was noted.

Methods: MC3T3-E1 cells were cultured in induced medium treated with icariin with or without dexamethasone.

[Study of interaction of umbelliferone with three aromatic amino acids by fluorescence spectroscopy].

The interaction between umbelliferone (UMB) with tryptophan (Trp), tyrosine (Tyr) and phenylalanine (Phe) was studied by using fluorescence (FS) and ultraviolet (UV) spectroscopy. The results show that UMB can strongly quench the fluorescence of the three aromatic amino acids with the maximum quenching wavelengths at 347, 303 and 282 nm, respectively. Data analyses based on the Stern-Volmer curve and the UV spectroscopy show that static quenching occurred through the formation of the complexes of UMB with each aromatic amino acid in a molar ratio of 1 : 1.

[Monitoring and analysis of vertical profile of atmospheric HONO, NO2 in boundary layer of Beijing].

Based on the scanning differential optical absorption spectroscopy (DOAS) system, field measurement of vertical profiles of HONO and NO2 was performed continuously from Aug. 27, 2007 to Sep. 4, 2007 in Chaoyang District of Beijing, and their vertical profiles were analyzed.

Enhanced sensing of ascorbic acid, dopamine and serotonin at solid carbon paste electrode with a nonionic polymer film.

A nonionic poly(2-amino-5-mercapto-thiadiazole) film was electrodeposited on a solid carbon paste electrode via a potential scanning procedure, and used for amperometric sensing of ascorbic acid (AA), dopamine (DA) and serotonin (ST). The highly electrocatalytic activity of the sensor to the three analytes was demonstrated from the sensitive and well separated voltammetric signals. The polymer film did not show significant accumulation effect on all the three species, reducing the fouling and deactivation of the electrode surface as well as the mutual interference among the analytes.

[Observational study of atmospheric HONO in summer of Beijing].

The concentration of HONO, NO2, O3 and other atmospheric pollutants were observed continuously by using differential optical absorption spectroscopy (DOAS) from 2007-08-14 to 2007-08-24 in Beijing, China. Diurnal variation characteristics of HONO and NO2 were analyzed. The HONO levels originated from the nocturnal direct emission were discussed.

[Monitoring and analysis of air pollutants using DOAS in winter of Beijing].

Based on the differential optical absorption spectroscopy (DOAS) technology, the measurement of air pollutants (SOz, NO2, HONO and HCHO) was performed continuously from Jan 19, 2007 to Feb 8, 2007 in Peking University campus. The typical diurnal variation characteristic of SO2 concentration, the main source and the meteorological factors that influence the pollutants were analyzed. The results indicated that the typical diurnal variation of SO2 concentration has the same shape as the letter "V" when wind speed was low, and in the afternoon the SO2 concentration was the lowest, while in other time it was high.