[Effect of toluene diisocyanate on lung function of workers].

Objective: To investigate the effect of long-term exposure to toluene diisocyanate (TDI) on the lung function of TDI-exposed workers.

Methods: A factory was selected for this occupational epidemiological investigation. The workers who were exposed to TDI and had complete physical examination records in recent 3 years were the exposed group (n = 45), while the company's administrative staff, logistics staff, and other non-TDI-exposed workers who had complete physical examination records in recent 3 years were the control group (n = 47).

[Effect of subchronic inhalation of ethylbenzene on expression of heme oxygenase-1 in rat renal tissues].

Objective: To investigate the effect of ethylbenzene on the expression of heme oxygenase-1 (HO-1) intrarenal tissues.

Methods: Forty male Sprague-Dawley rats were randomly and equally allocated to control group, low-dose exposure group, moderate-dose exposure group, and high-dose exposure group to inhale different doses of ethylbenzene (0, 433.5 mg/m(3) (100 ppm), 4335.

[Pathological changes of major organs after rats inhaled methyl ethyl ketone peroxide aerosol].

Objective: To investigate the pathological changes of major organs in rats that have inhaled methyl ethyl ketone peroxide (MEKP) aerosol and to provide clues to the oxidative damage mechanism of MEKP.

Methods: A total of 100 Sprague-Dawley rats (male-to-female ratio = 1:1) were randomly and equally divided into blank control group, solvent control group, and 50, 500, and 1000 mg/m(3) MEKP exposure groups to inhale clean air, solvent aerosol, or MEKP for 6 h per day, 5 d per week, for 13 weeks. A rat model of subchronic MEKP exposure was established.

[The inhibitory effect of latent transforming growth factor β1 activation and silicosis by CD36 targeted RNA interference in silicosis model of rat].

Objective: To investigate the inhibitory effects of CD36-targeting RNA interference on the latent transforming growth factor β1 (L-TGF-β1) activation and silicotic fibrosis in rat silicosis model.

Methods: Wistar rats were divided into four groups: saline control group (n=24), SiO2 model group (10 mg SiO2 per rat) (n=24), SiO2+Lv-shCD36 group (lentiviral vector expressing specific shRNA against CD36) (n=24), and SiO2+Lv-shCD36-NC group (non-silence control lentivirus) (n=24). At 7, 21, and 28 d after instillation, the rats were sacrificed.

[Influence of ethylbenzene on oxidative damage and apoptosis in rat renal epithelial cells NRK-52e].

Objective: To study the oxidative damage and apoptosis of renal tubular epithelial cells (NRK-52e cell line) induced by ethylbenzene.

Methods: NRK-52e cells were exposed to 30, 60, 90, 120 μmol/L ethylbenzene for 24 hours. Cell viability were measured using MTT, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), the contents of malondialdehyde (MDA) and glutathione (GSH) were detected respectively.

[The neurobehavioral effects of population occupationally exposed to ethylbenzene].

Objective: To evaluate the influence of ethylbenzene on the neurobehavior of occupationally exposed workers.

Methods: The exposure group consisted of 246 workers occupationally exposed to ethylbenzene and 172 staffs from the offices served as controls. The basic information on ethylbenzene exposure was collected by the questionnaire.

[The changes of blood neurotransmitter levels in workers occupationally exposed to ethylbenzene].

Objective: To explore the effects of occupational ethylbenzene exposure on blood neurotransmitter levels in population.

Methods: The exposure group consisted of 246 workers occupationally exposed to ethylbenzene and the control group was composed of 122 staffs from the offices. The basic information on ethylbenzene exposure was collected by the questionnaire.

[Effects of ethylbenzene on oxidative damage, ultrastructure and expressions of apoptosis-related genes in rat brain tissues].

Objective: To investigate the influence of ethylbenzene on oxidative damage, ultrastructure and the expressions of apoptosis-related genes in the rat brain tissues.

Methods: Four groups of 10 males of Sprague-Dawley rats were allocated randomly, and inhaled daily with different doses of ethylbenzene: 0, 433.5 mg/m³, 4335.

[Influence of ethylbenzene on the levels of mandelic acid and phenylglyoxylic acid in urine, ultrastructure and the expressions of Mitochondrial apoptotic-related proteins in the rat nephridial tissues].

Objective: To investigate the influence of ethylbenzene on the levels of mandelic acid (MA) and phenylglyoxylic acid (PGA) in urine, the ultrastructure and the expressions of mitochondrial apoptotic-related genes in the rat nephridial tissues.

Methods: Four groups of 10 males of Sprague-Dawley rats were allocated randomly into four groups: control (C) group, low (L) group, moderate (M) group and high (H) group, and inhaled daily with different doses of ethylbenzene: 0, 433.5 mg/m(3), 4335 mg/m(3), and 6500 mg/m(3) 6 h per day, 5 days per week for 13 weeks.

Exposure of mother-child and postpartum woman-infant pairs to DDT and its metabolites in Tianjin, China.

1,1,1-trichloro-2,2'-bis(4-chlorophenyl)ethane (DDT) exhibits its long persistence in the environment, unusual bioaccumulation, effects on wildlife, and the possibility of long-term adverse effects on human health, especially reproductive toxicity. Despite the prohibition of most persistent organochlorine pesticides in China, the presence of organochlorine residue, including DDT, has been widely indicated in environmental substance. However, scarce information is available about accumulative levels of DDT in human tissues in China.