Hair follicle stem cell proliferation and differentiation are achieved by miR-1285-3P through targeted regulation of NOTCH pathway.

The purpose of this experiment is to understand how miR-1285-3P regulates the NOTCH signaling pathway by targeting, thereby affecting the proliferation and differentiation of hair follicle stem cells. The cultured Inner Mongolia hair follicle stem cells were used in this experiment, and they were divided into control group, blank transfection group and miR-1285-3P transfection group. Among them, the control group was left untreated; the blank group was given miR-NC transfection; at the same time, the miR-1285-3P transfection group was given miR-1285-3P mimics for transfection.

Comparison of mitochondrial genome and development of specific PCR primers for identifying two scuticociliates, Pseudocohnilembus persalinus and Uronema marinum.

Background: Pseudocohnilembus persalinus and Uronema marinum (Ciliophora, Scuticociliatia), as parasitic scuticociliatid ciliates, were isolated from Scophthalmus maximus and Takifugu rubripes, respectively, in our previous studies. These ciliates are morphologically very similar; hence, it is difficult to identify specific scuticociliate species using traditional classification methods for performing taxonomic research and disease control studies.

Methods: We annotated the mitochondrial genomes of these two scuticociliates on the basis of previous sequencing, including analyses of nucleotide composition, codon usage, Ka/Ks, and p-distance.

Spectral phase effects and control requirements of coherent beam combining for ultrashort ultrahigh intensity laser systems.

Based on the premise that further improvements to the size and damage threshold of large-aperture optical components are severely limited, coherent beam combining (CBC) is a promising way to scale up the available peak power of pulses for ultrashort ultrahigh intensity laser systems. Spectral phase effects are important issues and have a significant impact on the performance of CBC. In this work, we analyze systematically factors such as spectral dispersions and longitudinal chromatism, and get the general spectral phase control requirements of CBC for ultrashort ultrahigh intensity laser systems.

Investigation of phase effects of coherent beam combining for large-aperture ultrashort ultrahigh intensity laser systems.

Large-aperture ultrashort ultrahigh intensity laser systems are able to achieve unprecedented super-high peak power. However, output power from a single laser channel is not high enough for some important applications and it is difficult to improve output power from a single laser channel significantly in the near future. Coherent beam combining is a promising method which combines many laser channels to obtain much higher peak power than a single channel.

Phase control requirements of high intensity laser beam combining.

Aiming at getting the general requirements of the beam combine for ignition scale laser facilities, the analytical expressions including the factors affecting the combine results are derived. The physical meanings of every part are illustrated. Based on these expressions, the effects of the factors, including the beam configuration, piston error, and tip/tilt error, are studied analytically and numerically.

Fractional Fourier transform of flat-topped multi-Gaussian beams.

The fractional Fourier transform (FRFT) of the flat-topped multi-Gaussian beam (FMGB) is investigated based on the three kinds of FRFT optical systems: Lohmann I, Lohmann II, and quadratic graded-index systems. The analytical expressions for the FRFT of the FMGB are derived based on the propagation of the FMGB through the three systems. By introducing a hard-edge aperture function, the analytical expressions for the FRFT of the FMGB carried out by the apertured FRFT optical systems are presented.

Propagation of flat-topped multi-Gaussian beams through an apertured ABCD optical system.

The generalized analytical expression for the propagation of flat-topped multi-Gaussian beams through a misaligned apertured ABCD optical system is derived. Using this analytical expression, the propagation characteristics of flat-topped multi-Gaussian beams through a spatial filter are investigated. The analytical formula of the electric field distribution in the focal plane is also derived for revealing the effects of the misalignment parameters clearly.

Characteristics of beam alignment in a high power four-pass laser amplifier.

Beam alignment is used to control the pointing, rotation, and position of a beam automatically. We give an overview of the beam alignment system for a four-pass amplifier system. The coupling relationships between dependent quantities and deviations thereof for parameters of key optical elements are analyzed using matrix optics techniques.