[Metabonomics and its application in Chinese medicine processing].

Chinese medicine processing is a procedure to process medicinal materials under the guidance of traditional Chinese medicine(TCM) theories by using unique methods in China. The medicinal materials can only be used clinically after proper processing. With the development of the modernization of TCM, it is difficult to solve the problems in the inheritance, development, and internationalization of Chinese medicine processing.

Critical Review of Synthesis, Toxicology and Detection of Acyclovir.

Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV's ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail.

HTRA1-related autosomal dominant cerebral small vessel disease.

Background: Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Recently, increasing evidence has shown that heterozygous HTRA1 mutations are also associated with cerebral small vessel disease (CSVD) with an autosomal dominant pattern of inheritance. This study was aimed to analyze the genetic and clinical characteristics of HTRA1-related autosomal dominant CSVD.

Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b-3p/PTEN.

Matrine, one of the main alkaloid components extracted from the traditional Chinese herb, Sophora flavescens Ait, has various pharmacological effects, and has been reported to exert antitumor activity in melanoma. In the current study, the molecular mechanisms underlying the inhibitory effects of matrine were investigated in melanoma cell line. It was initially confirmed that matrine inhibited proliferation, invasion and induced apoptosis in human A375 and SK-MEL-2 melanoma cell lines in vitro.

cDNA-AFLP analysis reveals differential gene expression in incompatible interaction between infected non-heading Chinese cabbage and Hyaloperonospora parasitica.

Non-heading Chinese cabbage (Brassica rapa ssp. chinensis) is one of the main green leafy vegetables in the world, especially in China, with significant economic value. Hyaloperonospora parasitica is a fungal pathogen responsible for causing downy mildew disease in Chinese cabbage, which greatly affects its production.

Transcriptomic and proteomic analyses provide new insights into the regulation mechanism of low-temperature-induced leafy head formation in Chinese cabbage.

Unlabelled: In Chinese cabbage, leafy head-related traits are directly related to the cabbage yield and marketability, which are often primarily concerned target for breeders. Although intensive studies has been on head formation in Chinese cabbage in the past decade, very scanty information is available on mechanism involved in the head formation under the influence of low temperature at transcriptome and proteome perspective. In this study, quantitative expression profiling based on RNA-Seq transcriptome and iTRAQ proteome were combined to investigate this trait for a global picture of the molecular dynamics.

[Diagnosis of Muscular Dystrophy Using Western Blot with Micro-sample of Muscle].

Objective: To diagnose muscular dystrophy using Western blot (WB) by improving the method of the protein extraction.

Method: Firstly,we compared the effect of different sample buffer solutions and processing Methods on the extraction of muscle protein in rats,then selected the appropriate extracting method and the process of the muscular protein.

Results: We put the selected sample buffer into the micro-sample,then mixed.

Effects of a feeding intervention in patients with Alzheimer's disease and dysphagia.

Aims And Objectives: This study aimed to investigate the effects of a feeding intervention in patients with Alzheimer's disease with dysphagia.

Background: In patients with Alzheimer's disease, inadequate food and fluid intake can result in malnutrition, dehydration and increased morbidity and mortality. Patients may lose self-care abilities such as self-feeding.

Moyamoya syndrome associated with Graves' disease: a case series study.

Objective: The aim of this study was to describe the clinical and radiological findings of patients with moyamoya syndrome and Graves' disease. Possible mechanisms predisposing these individuals to ischemic stroke are discussed.

Methods: We retrospectively analyzed 12 consecutive patients with both moyamoya syndrome and Graves' disease.

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals.

The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal impaired fasting blood glucose and glucose intolerance on the metabolism of offspring have been well established, the exact molecular and mechanistic basis that mediates these impacts remains largely unclear. Here we show that paternal prediabetes increases the susceptibility to diabetes in offspring through gametic epigenetic alterations.

[Effect of modified zhenzhu tiaozhi capsule on lipid peroxidation and endothelial functions in atherosclerotic rabbits].

Objective: To observe the anti-atherosclerotic effect and its possible mechanisms of Modified Zhenzhu Tiaozhi Capsule (MZTC) in rabbits.

Methods: 50 rabbits were divided into five groups, i.e.

Synthetic dye--inorganic salt hybrid colorants for application in thermoplastics.

Common synthetic dyes, e.g., Weak Acid Pink Red B (APRB, C.

[Adhesion of osteoblasts on the novel titanium alloy with bioactivity and wear coating].

Objective: The purpose of this study was to evaluate the rugosity with both of the bioactivity and the wear coating of a new type titanium implant material Ti-Zr-Sn-Mo-Nb(TZS), and to investigate the adhesion of osteoblasts on different coating surface.

Methods: Both surface topography of bioactivity and wear coating were examined with scanning electron microscope (SEM). The average roughness of two kinds coating were measured by portable roughometer.

[The effect of fufang zhenzhu tiaozhi capsule on lipid metabolism in atherosclerotic rabbits].

Objective: To observe the effect of fufang zhenzhu tiaozhi capsule (FTZ) on lipid metabolism in atherosclerotic rabbits.

Methods: 50 rabbits were divided into five groups: normal control group, model group, simvastatin group, the high-dose group and low-dose group of FTZ. The atherosclerotic model was established by feeding the rabbits with high fat diet.

[Effects of Huoxue Tongmai Lishui method on fundus fluorescein angiography of non-ischemic retinal vein occlusion: a randomized controlled trial].

Background: Huoxue Tongmai Lishui method, a traditional Chinese medicine treatment for eliminating water, activating and promoting blood circulation, could inhibit fundus hemorrhage on experimental retinal vein occlusion (RVO) with high obvious effective rate, and improve symptoms in traditional Chinese medicine. The action mechanism may be related to reducing plasma viscosity and non-perfusion area, and the formation of collateral circulation.

Objective: To explore the therapeutic effects of Huoxue Tongmai Lishui method (Sanxue Mingmu Tablet) on fundus fluorescent angiograph of non-ischemic retinal vein occlusion (RVO).

[Studying the biocompatibility of implant titanium alloy after surface treatment by sandblasting and etching].

Objective: The aim of this study was to investigate the in vitro effect of cell behavior on a new titanium alloy and coarsening surface with sandblasting and duplicate treated by sandblasting and acid etching (SLA), including cell proliferation, morphology as well as alkaline phosphatase expression.

Methods: The cell derived from calvarial bone of neonate and co-cultured with the surface treated titanium alloys in vitro. The samples were treated by mechanical polishing, the sandblasting and the SLA.