Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study.

Background: Evidence remains limited on the association between maternal ozone (O) exposure and congenital heart defects (CHDs) in offspring, and few studies have investigated the interaction and modification of paternal smoking on this association.

Methods: Using a sample including pregnant women at high risk of fetal CHD (with metabolic disease, first-trimester viral infection, family history of CHD, etc.) from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021, we examined the associations between maternal O exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this association.

Restrictive Cardiomyopathy Resulting from a Troponin I Type 3 Mutation in a Chinese Family.

Objective To identify the pathogenic variant responsible for restrictive cardiomyopathy (RCM) in a Chinese family.Methods Next generation sequencing was used for detecting the mutation and Results verified by sequencing. We used restriction enzyme digestion to test the mutation in the family members and 200 unrelated normal subjects without any cardiac inherited diseases when the mutation was identified.

[Prevalence and risk factors of atherosclerotic renal artery stenosis].

Objective: To explore the prevalence and risk factors of atherosclerotic renal artery stenosis (ARAS) in patients undergoing coronary angiography.

Methods: A total of 2506 patients with suspected and known coronary heart disease (CAD) at our hospital underwent simultaneous coronary and renal angiography. Renal artery stenosis was defined as at least one of renal artery stenosis ≥ 50% narrowing of luminal diameter.

[Risk factors and coronary angiography characteristics of female patients with acute coronary syndrome].

Objective: To assess the risk factors and coronary angiography characteristics of female patients with acute coronary syndrome (ACS).

Methods: A total of consecutive 986 inpatients with ACS who had undergone coronary angiography from March 2009 to August 2010 in our hospital were enrolled in this study. There were 303 female patients and 683 male patients.

[Correlation of fever to infection in patients with chemotherapy-induced neutropenia].

Background & Objective: The cancer patients with chemotherapy-induced neutropenia often suffer from fever and infection, but current opinions on the correlation of the fever to infection are controversial. This study aimed to investigate the incidence and correlation of fever and infection in cancer patients with chemotherapy-induced neutropenia.

Methods: Clinical data of 256 in-patients with chemotherapy-induced neutropenia from Jan.