Publications by authors named "Yan-ni Yang"
Crystal structure of F10 core protein from Mpox virus reveals its potential inhibitors.
Int J Biol Macromol
January 2025
Article Synopsis
- Mpox virus (MPXV) is a rare zoonotic disease that has resulted in over 15,600 cases and 537 deaths to date.
- The study focuses on the RNA polymerase (RNAP) of MPXV, which is crucial for early transcription, and reveals the high-resolution crystal structure of the F10 core protein, which stabilizes essential components of the RNAP complex.
- The research identified a cavity in the RNAP structure and screened 28 potential inhibitors, marking a significant step towards developing treatments for MPXV and similar emerging pathogens.*
Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent hyperplasia of the synovial membrane and progressive erosion of articular cartilage. Disequilibrium between the proliferation and death of RA fibroblast-like synoviocytes (RA-FLSs) is the critical factor in progression of RA. Naringin has been reported to exert anti-inflammatory and antioxidant effect in acute and chronic animal models of RA.
View Article and Find Full Text PDF[Ectopic expression of keratin 19 and integrin beta1 during wound healing process after microskin grafting in rats].
Zhonghua Shao Shang Za Zhi
October 2007
Objective: To observe the characteristics of keratin 19 and integrin beta1 expressions in the wound after microskin grafting , and to investigate the healing mechanism.
Methods: Full layer skin defects were created in twenty Sprague-Dawley rats and they were divided into two groups, i.e.
The granulation of aerobic sludges for high-rate biodegradation of organic wastewater containing aniline and chloroanilines was investigated in a laboratory-scale sequencing airlift bioreactor ( SABR). Aerobic granules were observed in 15 days after start-up in SABR. After subsequent 83 days, SABR was operated sequentially in superficial air velocity of 2.
View Article and Find Full Text PDF[Influence of mixed grafting of autologous and allogeneic microskin on burn wound healing in rats].
Zhonghua Shao Shang Za Zhi
August 2004
Objective: To observe the influence of mixed grafting of autologous and allogeneic microskin on burn wound healing.
Methods: Autologous microskin grafting (expansion rate 5:1) was employed as control. Autologous microskin mixed with the allogeneic microskin with the thickness of 0.