Achieving Record CH Packing Density for Highly Efficient CH/CH Separation with a Metal-Organic Framework Prepared by a Scalable Synthesis in Water.

Adsorptive CH/CH separation using metal-organic frameworks (MOFs) has emerged as a promising technology for the removal of CH (acetylene) impurity (1 %) from CH (ethylene). The practical application of these materials involves the optimization of separation performance as well as development of scalable and green production protocols. Herein, we report the efficient CH/CH separation in a MOF, Cu(OH)INA (INA: isonicotinate) which achieves a record CH packing density of 351 mg cm at 0.

Recovery of High-Purity SF from Humid SF/N Mixture within a Co(II)-Pyrazolate Framework.

Sulfur hexafluoride (SF) is extensively employed in the power industry. However, its emissions significantly contribute to the greenhouse effect. The direct recovery of high purity SF from industrial waste gases would benefit its sustainable use, yet this represents a considerable challenge.

Enabling CH/CO Separation Under Humid Conditions with a Methylated Copper MOF.

As a unique subclass of metal-organic frameworks (MOFs), MOFs with open metal site (OMS) are demonstrated efficient gas separation performance through pi complexation with unsaturated hydrocarbons. However, their practical application faces the challenge of humidity that causes structure degradation and completive binding at the OMS. In this work, the effect of linker methylation of a copper MOF (BUT-155) on the CH/CO separation performance under humid condition is evaluated.

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis.

Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress and inflammation play central roles in progressive renal fibrosis.

Non-CO greenhouse gas separation using advanced porous materials.

Global warming has become a growing concern over decades, prompting numerous research endeavours to reduce the carbon dioxide (CO) emission, the major greenhouse gas (GHG). However, the contribution of other non-CO GHGs including methane (CH), nitrous oxide (NO), fluorocarbons, perfluorinated gases, should not be overlooked, due to their high global warming potential and environmental hazards. In order to reduce the emission of non-CO GHGs, advanced separation technologies with high efficiency and low energy consumption such as adsorptive separation or membrane separation are highly desirable.

Membranous nephropathy: Mechanistic insights and therapeutic perspectives.

Membranous nephropathy (MN) is one of the most common causes of non-diabetic nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20% are associated with other systemic diseases or exposures (secondary MN). Autoimmune reaction is the main pathogenic factor of MN, and the discovery of autoantigens including the phospholipase A receptor and thrombospondin type-1 domain-containing protein 7A has led to new insights into the pathogenesis, they can induce humoral immune responses led by IgG makes them suitable for the diagnosis and monitoring of MN.

1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway.

Background And Purpose: In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the molecular pathways targeted by metabolites remain enigmatic.

Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10.

Biomarkers are urgently required for predicting rejection so that anti-rejection treatment can be taken early to protect the allograft from irreversible damage. We hypothesized that the combination of circulating fractalkine, IFN-γ and IP-10 might serve as effective biomarkers for predicting early acute renal allograft rejection. We conducted a retrospective study of 87 subjects, who were classified into acute rejection group (ARG; n = 38) and non-rejection group (NRG; n = 49).

[Spatial Distribution, Sources and Bioavailability of Heavy Metals in the Surface Sediments of Longjiang River, Southern China].

In order to evaluate the pollution status, possible sources, and bioavailability of heavy metals (As, Cd, Pb, Sb, Zn, and Tl), 33 surface sediments were collected from Longjiang River, Southern China. The total concentrations and potential bioavailable concentrations of the heavy metals were analyzed using ICP-MS. Enrichment factors (EFs), Pearson correlation analysis, and principal component analysis (PCA) were used to further assess their pollution degree and potential sources.

[Spatial Distribution Characteristics and Potential Ecological Risk of Antimony and Selected Heavy Metals in Sediments of Duliujiang River].

In order to investigate the spatial distribution characteristics of Sb and selected heavy metals, and to discriminate their sources and potential ecological risks in surface sediments of the Duliujiang river,a total of 62 surface sediment samples were collected in this study. Total contents of Sb, As, Cd, Co, Cr, Cu, Mo, Ni, Pb, Tl, Zn and Fe in these samples were measured by inductively coupled plasma mass spectrometry(ICP-MS) and the inductive plasma optical emission spectrometry(ICP-OES). Principal component analysis(PCA) and Pearson correlation analysis were used to deduce the potential sources of these elements.

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5.

The chemokine receptor CCR5 is an important anti-HIV (human immunodeficiency virus) drug target owning to its pivotal role in HIV-1 viral entry as a co-receptor. Here, we present a 2.9 Å resolution crystal structure of CCR5 bound to PF-232798, a second-generation oral CCR5 antagonist currently in phase II clinical trials.

Comparison of the characteristics of macrophages derived from murine spleen, peritoneal cavity, and bone marrow.

Macrophages have a diverse set of functions based upon their activation states. The activation states, including resting (M0) and polarizing (M1 and M2) states, of macrophages derived from the mouse bone marrow, spleen, and peritoneal cavity (BMs, SPMs, and PCMs, respectively) were compared. We evaluated the macrophage yield per mouse and compared the surface markers major histocompatibility complex (MHC) II and CD86 by flow cytometry.

[Effects of Qufengtongluo Recipe on podocin mRNA expression and podocyte morphology in rats with adriamycin-induced nephropathy].

Objective: To observe the effects of Qufengtongluo Recipe (QFTLR) on the expression of podocin mRNA and podocyte morphology in rats with adriamycin-induced nephropathy (AN), and explore the possible mechanism mediating the therapeutic effect of QFTLR on nephropathic proteinuria.

Methods: SD rats were randomized into normal control group, AN model group (established by a single injection of adriamycin via the tail vein), and 3 intervention groups with QFTLR, prednisone, or benazepril treatment. After the corresponding treatments, the expression of podocin mRNA in the renal tissues was detected by RT-PCR methods, and the morphological changes of the podocytes were examined by electron microscope.

[Effects of qufengtongluo recipe on expressions of HSPG mRNA and protein in adriamycin-induced nephropathy rats].

Objective: To investigate the expression of HSPG in glomerular base membrane of adriamycin-induced nephropathy (AN) rats, and the effect of Qufengtongluo recipe on HSPG mRNA expression and proteinuria in AN rats.

Methods: One hundred forty rats were used in this study, including 32 rats in normal control group. AN was induced in the left rats by a single tail intravenous injection of adriamycin.

[Clinical and pathological study on effects of Qianggan Capsule combined lamivudine on hepatic fibrosis in patients with chronic hepatitis B].

Objective: To study the therapeutic effects of Qianggan Capsule (QC) combined Lamivudine on hepatic fibrosis in patients with chronic hepatitis B.

Methods: Eighty-five patients were randomly divided into two groups, group A (40 cases) were treated with QC and Lamivudine and group B (45 cases) were treated with QC alone both for 6 months. Hepatic fibrosis related indexes and pathologic examination of liver biopsy were performed within 3 months before treatment and in 1 month after treatment.

[Relationship between the genotypes of hepatitis B virus and the severity of liver diseases].

Objective: To investigate the relationship between different genotypes of hepatitis B virus (HBV) and the severity of liver diseases.

Methods: The S nucleotide sequences of HBV strains isolated from plasma samples of 284 patients were detected and compared. Among them, 87 patients were HBV asymptomatic carriers (ASC), 157 chronic hepatitis B (CHB), 22 liver cirrhosis (LC), and 18 hepatocellular carcinoma (HCC).