Exploring the predictive values of CRP and lymphocytes in coronary artery disease based on a machine learning and Mendelian randomization.

Purpose: To investigate the predictive value of leukocyte subsets and C-reactive protein (CRP) in coronary artery disease (CAD).

Methods: We conducted a Mendelian randomization analysis (MR) on leukocyte subsets, C-reactive protein (CRP) and CAD, incorporating data from 68,624 patients who underwent coronary angiography from 2010 to 2022. After initial screening, clinical data from 46,664 patients were analyzed.

Research Advances in Targeted Therapy for Heart Failure.

Cardiovascular disease is one of the major diseases threatening the health of Chinese residents, and the death rate has long been the highest on the disease spectrum in China. With the progress of population aging, the prevalence and mortality of cardiovascular diseases remain on the rise, and the current treatment effect on and prognosis of heart failure (HF) are not satisfactory. It is particularly important to explore the potential pathogenic mechanisms of HF and identify new therapeutic targets.

Identification of potential therapeutic targets for plaque vulnerability based on an integrated analysis.

Background And Aims: This study aimed to explore potential hub genes and pathways of plaque vulnerability and to investigate possible therapeutic targets for acute coronary syndrome (ACS).

Methods And Results: Four microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs), weighted gene coexpression networks (WGCNA) and immune cell infiltration analysis (IIA) were used to identify the genes for plaque vulnerability.

A causal analysis of the relationship between exposure to sunlight and colorectal cancer risk: A Mendelian randomization study.

Several observational studies have found that exposure to sunlight reduces the risk of colorectal cancer (CRC). However, sun exposure remains ambiguous in its relationship to CRC. We carried out a Mendelian randomization (MR) study to explore the potential associations between them.

Employing graph attention networks to decode psycho-metabolic interactions in Schizophrenia.

Schizophrenia is a severe mental disorder characterized by intricate and underexplored interactions between psychological symptoms and metabolic health, presenting challenges in understanding the disease mechanisms and designing effective treatment strategies. To delve deeply into the complex interactions between mental and metabolic health in patients with schizophrenia, this study constructed a psycho-metabolic interaction network and optimized the Graph Attention Network (GAT). This approach reveals complex data patterns that traditional statistical analyses fail to capture.

The Enhancement of Hepatic Parenchyma and Portal Vein in different CLD Groups: A Comparative Study of Gadoxetic Acid and Gadopentetate Dimeglumine.

Background: Chronic liver disease (CLD) will affect the enhancement of hepatic parenchyma and portal vein on abdominal-enhanced MRI.

Objective: To investigate the difference in liver parenchyma and portal vein enhancement in patients with CLD of different liver function grades between Gd- EOB-DTPA and Gd-DPTA in the portal venous phase (PVP).

Methods: This retrospective study included 218 patients with CLD who had undergone abdominal enhanced MRI from January 2019 to June 2020.

Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function.

Objectives: Colitis is a global disease usually accompanied by intestinal epithelial damage and intestinal inflammation, and an increasing number of studies have found natural products to be highly effective in treating colitis. Anemoside B4 (AB4), an abundant saponin isolated from Pulsatilla chinensis (Bunge), which was found to have strong anti-inflammatory activity. However, the exact molecular mechanisms and direct targets of AB4 in the treatment of colitis remain to be discovered.

Associations of body roundness index with cardiovascular and all-cause mortality: NHANES 2001-2018.

Body roundness index (BRI) was associated with cardiovascular diseases. But the relationship between BRI with cardiovascular disease (CVD) mortality and all-cause mortality remains largely unknown in hypertensive patients. This prospective cohort study included patients with hypertension who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 through 2018, and aimed to evaluate the association between BRI with CVD mortality and all-cause mortality.

The effect of the CPP size on the nonlinear optical properties of the new necklace-type molecules formed by carborane and [n]Cycloparaphenylenes(n = 8-11).

The new necklace-type molecules were formed by [8-13]CPP and carborane, which further manipulated the size of the macroring, revealing the effect of size on its luminescence behavior. In this work, the effects of ring size on the absorption spectrum, electron excitation and nonlinear optical properties of the compounds were investigated in detail, aiming to reveal an effective way to improve the optical properties of these necklace-type compounds. The absorption spectra of the compounds showed that the size of the CPP ring had little effect on the spectral shape and position, but the electron transition information showed that there were the significant charge transfer within the CPP ring and a gradual enhancement of interfragment charge transfer from the CPP ring to carborane.

Mechanism of salidroside against coronary artery disease by network pharmacology analysis.

Background: Rosenroot (Rhodiola rosea) is a traditional Chinese herbal medicine. It has been used to treat patients with coronary artery disease (CAD). Salidroside is the main active constituent of rosenroot.

Correlation between the Human Development Index and the Incidence and Mortality of Non-Hodgkin Lymphoma.

Objective: This study was to examine the relationship between socioeconomic status and the incidence and mortality of non-Hodgkin lymphoma (NHL).

Methods: We compared the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and the ASMR to ASIR ratio (MIR) at national and regional levels and studied the correlation between the MIR and the human development index (HDI) in 2012 and 2018.

Results: The highest ASIR was in North America in 2012 and in Australia in 2018, and the lowest ASIR was in Central and South Asia in both 2012 and 2018.

Effect of intermolecular interaction of the charge-transfer complex between molecular "tweezers" and C/C on second-order nonlinear optical properties.

To enhance understanding of the correlation between the intermolecular interaction and second-order nonlinear optical (NLO) properties, we studied a "molecular tweezer" with two corannulene substituents linked by a tetrahydro[5]helicene imide, which enabled highly sensitive and selective complexation of C/C through convex-concave π-π interactions. The geometric structure, molecular orbitals, intermolecular interactions, electron absorption spectra and second-order NLO properties of the charge-transfer (CT) complexes formed by molecular tweezers and C/C were studied by density functional theory. Larger fullerenes helped to increase the intermolecular interaction and CT, thereby increasing the first hyperpolarizabilities of CT complexes.

Effects of Atypical Hydrogen Bonds and π-π Interactions on Nonlinear Optical Properties: Dimers of Triangular Structures Based on Perylene, Naphthalene, and Pyromellitic Diimides.

Nonlinear optical (NLO) materials have become important materials in the field of high-speed optical devices due to the changes in light absorption and refraction caused by the photoelectric field. Compounds tend to exist as aggregates rather than single molecules, so intermolecular interactions are crucial to the nature of aggregates. Therefore, to study the effects of intermolecular interactions on nonlinear optical properties, we use a dimer simplified model and adopt the methods of controlling variables, which are the different intermolecular interactions resulting from the different stacking patterns of dimers based on the same monomer structures (2PMDI-1NDI and 2NDI-1PDI).

The organic co-crystals formed using naphthalenediimide-based triangular macrocycles and coronene: intermolecular charge transfers and nonlinear optical properties.

Formation of organic co-crystals is an effective strategy to synthesize near infrared emission and nonlinear optical (NLO) materials, which often show "1 + 1 > 2" performance. Moreover, the crystallization process can be effectively regulated through supramolecular interactions; thus the properties of co-crystal materials can also be flexibly regulated. Here, in order to further understand the nature and formation mechanism of co-crystals from the perspective of theoretical research, we studied the structures, intermolecular interactions, absorption spectra, charge transfer (CT) characteristics and nonlinear optical (NLO) properties of the newly synthesized organic co-crystals formed between naphthalenediimide based triangles (NDI, acceptor) and coronene (COR, donor).

Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease.

Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment.

A validated LC-MS/MS method for the determination of hederasaponin C: Application to pharmacokinetics-pharmacodynamics studies in the therapeutic area of acetic acid-induced ulcerative colitis in rats.

Hederasaponin C (HSC), one of the main components of Pulsatilla chinensis, is considered as a potential drug for the treatment of inflammatory bowel disease. In the present research, we developed a pharmacokinetics-pharmacodynamics model to describe the concentration-effect course of drug action following the intraperitoneal injection of HSC in colitis rats. A sensitive UPLC-MS/MS method was established for the the determination of HSC in rat plasma to explore the pharmacokinetics properties.

Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation.

Hederacoside C (HSC) has attracted much attention as a novel modulator of inflammation, but its anti-inflammatory mechanism remains elusive. In the present study, we investigated how HSC attenuated intestinal inflammation in vivo and in vitro. HSC injection significantly alleviated TNBS-induced colitis by inhibiting pro-inflammatory cytokine production and colonic epithelial cell apoptosis, and partially restored colonic epithelial cell proliferation.

Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes.

Background: Type 1 diabetes (T1D), a chronic metabolic and autoimmune disease, seriously endangers human health. In recent years, mesenchymal stem cell (MSC) transplantation has become an effective treatment for diabetes. Menstrual blood-derived endometrial stem cells (MenSC), a novel MSC type derived from the decidual endometrium during menstruation, are expected to become promising seeding cells for diabetes treatment because of their noninvasive collection procedure, high proliferation rate and high immunomodulation capacity.

Perinatal outcomes of singleton live births after preimplantation genetic testing during single frozen-thawed blastocyst transfer cycles: a propensity score-matched study.

Objective: To determine whether singleton pregnancy achieved after preimplantation genetic testing (PGT) is associated with a higher risk of adverse perinatal outcomes than in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) singleton pregnancy.

Design: A retrospective cohort study.

Setting: A university-affiliated fertility center.

Assembling of Perylene, Naphthalene, and Pyromellitic Diimide-Based Materials and Their Third-Order Nonlinear Optical Properties.

π-conjugated aromatic diimides with chemical stability, heat resistance, and redox activity have attracted more attention due to their excellent fluorescence quantum yield in solution. The planar perylene diimide (PDI) derivatives generally have aggregation-induced emission quenching in the solid state, while the cyclic trimers based on pyromellitic diimides (PMDIs), naphthalene diimides (NDIs), and PDIs can increase the fluorescence quantum yield in the solid state and have large two-photon absorption cross section, which can be used as excellent nonlinear optical (NLO) materials. Therefore, this paper will study the effects of multiple assembly modes of the three monomers on the NLO responses of materials.

The state of social science research on COVID-19.

Research on COVID-19 has proliferated rapidly since the outbreak of the pandemic at the end of 2019. Many articles have aimed to provide insight into this fast-growing theme. The social sciences have also put effort into research on problems related to COVID-19, with numerous documents having been published.