Publications by authors named "Yan-han Jia"
Article Synopsis
- ABCB1 and ABCG2 are crucial transporters linked to multidrug resistance (MDR), and this study developed imidazo[1,2-]pyridine derivatives aimed at inhibiting both targets.
- One of the compounds demonstrated significant inhibition of the efflux function of both transporters without causing noticeable cytotoxicity and improved the effects of antiproliferative drugs in the lab.
- The compound worked by slightly reducing ATPase activity and not altering the expression of the transporters, suggesting it could be a useful addition to standard chemotherapy treatments in overcoming resistance.
