Publications by authors named "Yan-Zhi Ge"
Peripheral blood mononuclear cells (PBMC), sourced autologously, offer numerous advantages when procured: easier acquisition process, no in vitro amplification needed, decreased intervention and overall increased acceptability make PBMC an attractive candidate for cell therapy treatment. However, the exact mechanism by which PBMC treat diseases remains poorly understood. Immune imbalance is the pathological basis of many diseases, with macrophages playing a crucial role in this process.
View Article and Find Full Text PDFBackground: Intervertebral disc degeneration (IVDD) is the main cause of low back pain (LBP), but the specific regulatory factors, pathways and specific molecular mechanisms remain unclear.
Methods: We identified and quantitatively analyzed Pfirrmann Grade II (n=3) and Pfirrmann Grade IV (n=3) pulposus samples via MRI. The differential abundance of proteins in the samples was determined and quantitatively analyzed by relative and absolute quantitative analysis of the isotope marker levels combined with the liquid chromatography-tandem mass spectrometry (LC‒MSMS/MS).
Article Synopsis
- Stroke is a major global health issue, with ischemic stroke (IS) making up about 80% of cases and showing different impacts on males and females, where females may face greater challenges.
- The study utilized weighted gene co-expression network analysis (WGCNA) on various datasets to identify key genetic modules and core genes associated with IS in female patients, ultimately selecting ten significant genes for further exploration.
- The research also employed CIBERSORT to analyze immune cell types in female IS patients compared to normal controls, highlighting new potential treatment targets based on immune profiles.